(Pyrrolidin-3-yl)methanesulfonamide hydrochloride | 2138116-07-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: (Pyrrolidin-3-yl)methanesulfonamide hydrochloride
• 英文别名: pyrrolidin-3-ylmethanesulfonamide;hydrochloride
• CAS: 2138116-07-9
• 化学式: C5H13ClN2O2S
• 分子量: 200.69
• InChiKey: YWZVKNUBLNQNOZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.69
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  80.6
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• PHARMACEUTICAL COMPOUNDS
  申请人：F.HOFFMANN-LA ROCHE AG

  公开号：EP2041139A2

  公开（公告）日：2009-04-01
• NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS
  申请人：Inflazome Limited

  公开号：EP3668861A1

  公开（公告）日：2020-06-24
• COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY
  申请人：Novartis AG

  公开号：EP3914583A1

  公开（公告）日：2021-12-01
• [EN] PHARMACEUTICAL COMPOUNDS<br/>[FR] COMPOSÉS PHARMACEUTIQUES
  申请人：PIRAMED LTD

  公开号：WO2007127175A2

  公开（公告）日：2007-11-08

  [EN] Compounds of Formulae Ia and Ib, and stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia and Ib for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
  [FR] Les composés de Formule Ia et Ib, ainsi que les stéréoisomères, isomères géométriques, tautomères, solvates, métabolites et sels de qualité pharmaceutique desdits composés peuvent être employés dans l'inhibition des lipides kinases, y compris PI3K, et dans le traitement de troubles les faisant intervenir, tels que le cancer. La présente invention a également pour objet des méthodes d'utilisation des composés de Formule Ia et Ib dans des diagnosticsin vitro, in situ et in vivo, ainsi que dans le traitement prophylactique ou thérapeutique de tels troubles dans les cellules de mammifères, ou d'états pathologiques associés.
• [EN] NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS DE SULFONAMIDE CARBOXAMIDE
  申请人：INFLAZOME LTD

  公开号：WO2019034686A1

  公开（公告）日：2019-02-21

  The present invention relates to compounds of formula (I): Formula (I) wherein Q is selected from O or S; R1 is a saturated or unsaturated, optionally substituted hydrocarbyl group optionally including one or more heteroatoms N, O or S; and R2 is a cyclic group substituted at the α-position with a monovalent heterocyclic 10 group or a monovalent aromatic group, wherein a ring atom of the heterocyclic or aromatic group is directly attached to the α ring atom of the cyclic group, wherein the heterocyclic or aromatic group may optionally be substituted, and wherein the cyclic group may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP3.