(1R-trans) (1-Aminomethyl-3-methyl-cyclohexyl)-methanesulfonic acid | 227626-05-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: (1R-trans) (1-Aminomethyl-3-methyl-cyclohexyl)-methanesulfonic acid
• 英文别名: [(1R,3R)-1-(aminomethyl)-3-methylcyclohexyl]methanesulfonic acid
• CAS: 227626-05-3
• 化学式: C₉H₁₉NO₃S
• 分子量: 221.321
• InChiKey: ANTFMGULIQOYJM-RKDXNWHRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  88.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Method of treating attention deficit hyperactivity disorder
  申请人：——

  公开号：US20040006073A1

  公开（公告）日：2004-01-08

  This invention relates to a method of treating ADHD by administering an alpha2delta ligand such as, for example, gabapentin or pregabalin, or a pharmaceutically acceptable salt thereof.

  这项发明涉及通过给予α2δ配体（例如加巴喷丁或普雷加巴林或其药用盐）来治疗注意力缺陷多动障碍的方法。
• Method of treating tinnitus
  申请人：Dooley James David

  公开号：US20060100281A1

  公开（公告）日：2006-05-11

  The invention relates to a method of treating tinnitus by administering an alpha2delta ligand such as, for example, a compound of Formula and pharmaceutically acceptable salts thereof, wherein R 1 is hydrogen or straight or branched lower alkyl, and n is an integer of from 4 to 6.

  本发明涉及一种通过给予α2δ配体治疗耳鸣的方法，例如，给予公式中的化合物及其药学上可接受的盐，其中R1为氢或直链或支链低碳基，n为4到6的整数。
• Method of treating cartilage damage
  申请人：——

  公开号：US20040097405A1

  公开（公告）日：2004-05-20

  The invention relates to a method of preventing or treating cartilage damage by administering a GABA analog such as, for example, a compound of Formula 1 and pharmaceutically acceptable salts thereof, wherein R 1 is hydrogen or straight or branched lower alkyl, and n is an integer of from 4 to 6.

  本发明涉及一种通过给予GABA类似物（例如，公式1中的化合物及其药学上可接受的盐），其中R1为氢或直链或支链低烷基，n为4至6的整数，来预防或治疗软骨损伤的方法。
• PHARMACEUTICAL USES FOR ALPHA2DELTA LIGANDS
  申请人：Dooley James David

  公开号：US20070213401A1

  公开（公告）日：2007-09-13

  The invention relates to a method of treating central nervous system disorders and other disorders by administering an alpha2delta ligand such as, for example, a compound of the formula or a pharmaceutically acceptable salt thereof, wherein R 1 is hydrogen or straight or branched lower alkyl, and n is an integer of from 4 to 6.

  该发明涉及一种通过给予α2δ配体来治疗中枢神经系统疾病和其他疾病的方法，例如给予公式中的化合物或其药学上可接受的盐，其中R1为氢或直链或支链低碳基，n为4到6的整数。
• Combinations of an endothelin receptor antagonist and an antiepileptic compound having pain alleviating properties or analgesic
  申请人：——

  公开号：US20030232787A1

  公开（公告）日：2003-12-18

  The present invention is a novel combination effective for alleviating pain comprising a pain alleviating effective amount of an endothelin receptor antagonist or a pharmaceutically acceptable salt thereof and from 1 to 3 compounds independently selected from the group consisting of antiepileptic compounds having pain alleviating properties and analgesics, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising same. The administration of endothelin receptor antagonists in these novel combinations results in an improved reduction in the frequency and severity of pain. The incidence of unwanted side effects can be reduced by these novel combinations in comparison to using higher doses of a single agent treatment to achieve a similar therapeutic effect. The present invention is also directed to methods of using effective amounts of the novel combinations and pharmaceutical compositions thereof to treat pain in mammals, including a human.

  本发明是一种有效缓解疼痛的新型复方制剂，它包含缓解疼痛有效量的内皮素受体拮抗剂或其药学上可接受的盐，以及1至3种独立选自具有缓解疼痛特性的抗癫痫化合物和镇痛剂及其药学上可接受的盐组成的化合物，以及包含这些化合物的药物组合物。在这些新型组合物中施用内皮素受体拮抗剂，可有效降低疼痛的频率和严重程度。与使用较大剂量的单药治疗以达到类似的治疗效果相比，这些新型组合物可以降低不希望出现的副作用的发生率。本发明还涉及使用有效量的新型组合物及其药物组合物治疗哺乳动物（包括人类）疼痛的方法。