3-phenyl-propenal 4-phenyl-thiosemicarbazone | 72488-61-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-phenyl-propenal 4-phenyl-thiosemicarbazone
• 英文别名: cinnamaldehyde-(4-phenyl thiosemicarbazone)；Zimtaldehyd-(4-phenyl-thiosemicarbazon)；4-Phenyl-1-cinnamal-thiosemicarbazid；Zimtaldehyd-<4-phenyl-thiosemicarbazon>；1-(Cinnamylideneamino)-3-phenylthiourea
• CAS: 72488-61-0
• 化学式: C₁₆H₁₅N₃S
• 分子量: 281.381
• InChiKey: VUSJWJPMCCHPMX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  68.5
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2930909090

反应信息

• 作为反应物：
  描述：

  3-phenyl-propenal 4-phenyl-thiosemicarbazone 在 碘 作用下， 以 乙醇 为溶剂， 生成 phenyl-(5-styryl-[1,3,4]thiadiazol-2-yl)-amine
  参考文献：
  名称：

  Sen,A.B.; Gupta,S.K., Journal of the Indian Chemical Society, 1962, vol. 39, p. 628 - 634

  摘要：

  DOI：
• 作为产物：
  描述：

  potassium phenylcarbamodithioate 在 一水合肼 作用下， 以 甲醇 、 水 为溶剂， 反应 27.0h， 生成 3-phenyl-propenal 4-phenyl-thiosemicarbazone
  参考文献：
  名称：

  Organotin(IV) complexes of thiohydrazones: synthesis, characterization and antifungal study

  摘要：

  Some new organotin(IV) complexes with salicylaldehyde aniline-N-thiohydrazone (L-1) and cinamaldehyde aniline-N-thiohydrazone (L-2) of the type (p-ClC6H4)(3)Sn[L] Cl and (p-ClC6H4)(2)Sn[L]Cl-2 have been synthesized (where L=L-1 and L-2). The complexes and ligands were characterized by elemental analysis and spectral (UV-vis, IR and H-1 NMR) studies. In all the complexes, ligands act as bidentate, coordination through sulphur and azomethane nitrogen. Complexes are 1:1 metal ligands complexes. Antifungal studies of some complexes against Rhizoctonia bataticola fungal strain have been carried out. (c) 2004 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2004.11.035

文献信息

• [EN] USE OF DYNAMIC MIXTURES FOR A CONTROLLED RELEASE OF FRAGRANCES<br/>[FR] UTILISATION DE MELANGES DYNAMIQUES POUR LIBERATION CONTROLEE DE FRAGRANCES
  申请人：FIRMENICH & CIE

  公开号：WO2006016248A1

  公开（公告）日：2006-02-16

  The present invention relates to a delivery system in the form of a dynamic mixture obtained by reacting together, in the presence of water, at least one hydrazine derivative with at least one perfuming, flavoring, insect repellent or attractant, bactericide and/or fungicide aldehyde or ketone. The invention's mixture is capable of releasing in a controlled and prolonged manner said aldehyde or ketone in the surrounding environment. Furthermore, the present invention concerns also the use of said dynamic mixtures as perfuming ingredients as well as the perfuming compositions or perfumed articles comprising the invention's mixtures.

  本发明涉及一种交互反应得到的动态混合物形式的递送系统，所述动态混合物是通过在水的存在下，将至少一种肼衍生物与至少一种香料、调味剂、驱虫剂或诱引剂、杀菌剂和/或杀菌醛或酮一起反应而获得的。本发明的混合物能够在周围环境中以受控和持久的方式释放所述的醛或酮。此外，本发明还涉及将所述动态混合物用作香料成分，以及包含本发明混合物的香水组合物或香水制品的用途。
• Development of bis-thiazoles as inhibitors of triosephosphate isomerase from Trypanosoma cruzi. Identification of new non-mutagenic agents that are active in vivo
  作者：Guzmán Álvarez、Jennyfer Martínez、Javier Varela、Estefania Birriel、Eugenia Cruces、Martín Gabay、Sandra M. Leal、Patricia Escobar、Beatriz Aguirre-López、Nallely Cabrera、Marietta Tuena de Gómez-Puyou、Armando Gómez Puyou、Ruy Pérez-Montfort、Gloria Yaluff、Susana Torres、Elva Serna、Ninfa Vera de Bilbao、Mercedes González、Hugo Cerecetto

  DOI：10.1016/j.ejmech.2015.06.018

  日期：2015.7

  Triosephosphate isomerase from Trypanosoma cruzi (TcTIM), the etiologic agent of this disease, has been proposed as a druggable target. Some bis-benzothiazoles have been described as irreversible inhibitors of this enzyme. On the other hand, new bioactive furane-containing thiazoles have been described as excellent in vivo anti-T. cruzi agents. This encouraged us to design and develop new bis-thiazoles with potential

  被忽视的疾病美国锥虫病是拉丁美洲的主要健康问题之一。已经提出了来自该病的病原体克氏锥虫（Tc TIM）的磷酸三糖异构酶作为可药物治疗的靶点。一些双苯并噻唑被描述为该酶的不可逆抑制剂。另一方面，已将新型的具有生物活性的含呋喃的噻唑描述为极好的体内抗克鲁维氏菌剂。这鼓励我们设计和开发新的双噻唑类药物，有可能用作美国锥虫病的药物。双-噻唑5，3,3'-烯丙基-2,2'-双[3-（2-呋喃基）-2- propenylidenehydrazono] -2,2'，3,3'-四氢-4,4'-联噻唑，表现最好体外抗克氏锥虫 谱具有比参比药物Nifurtimox和Benznidazole更高的选择性指数，可对抗寄生虫的a药形式。该衍生物显示边际活性对锝TIM然而双-噻唑14，3-烯丙基-2- [3-（2-呋喃基）-2- propenylidenehydrazono] -3'-苯基-2' - （3-苯基-2-丙二烯二氢偶氮]
• Pulvermacher, Chemische Berichte, 1894, vol. 27, p. 623
  作者：Pulvermacher

  DOI：——

  日期：——
• Shah,I.D.; Trivedi,J.P., Journal of the Indian Chemical Society, 1963, vol. 40, p. 889 - 893
  作者：Shah,I.D.、Trivedi,J.P.

  DOI：——

  日期：——
• Sen,A.B.; Gupta,S.K., Journal of the Indian Chemical Society, 1962, vol. 39, p. 628 - 634
  作者：Sen,A.B.、Gupta,S.K.

  DOI：——

  日期：——