alpha-Benzamido-4-hydroxy-3-methoxy-cinnamic acid | 35150-10-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: alpha-Benzamido-4-hydroxy-3-methoxy-cinnamic acid
• 英文别名: 2-benzamido-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
• CAS: 35150-10-8
• 化学式: C₁₇H₁₅NO₅
• 分子量: 313.31
• InChiKey: SSYWXIPQHQHKGX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  95.9
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-(4-hydroxy-3-methoxybenzylidene)-2-phenyl-5(4H)-oxazolone 在 potassium superoxide 、 四乙基溴化铵 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以18%的产率得到alpha-Benzamido-4-hydroxy-3-methoxy-cinnamic acid
  参考文献：
  名称：

  Singh, Krishna Nand; Kumar, Rajesh, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2005, vol. 44, # 2, p. 381 - 386

  摘要：

  DOI：

文献信息

• Catalytic asymmetric hydrogenation
  申请人：Monsanto Company

  公开号：US04261919A1

  公开（公告）日：1981-04-14

  Process for the homogeneous catalytic hydrogenation of .beta.-substituted-.alpha.-acylamido-acrylic acids which yields, after hydrogenation, an optically active mixture. The process comprises the hydrogenation of .beta.-substituted-.alpha.-acylamidoacrylic acids in the presence of an optically active coordinated metal complex hydrogenation catalyst, in which the metal is selected from the group consisting of rhodium, iridium, ruthenium, osmium, palladium and platinum. This process is a generalized process for any asymmetric hydrogenation of .beta.-substituted-.alpha.-acylamido-acrylic acids in which one .alpha.-amino acid enantiomorph is the desired end-product. It is especially useful for the preparation of .alpha.-amino acids found in nature which possess optical activity and which have a hydrogen attached to the asymmetric center. This invention also relates to new optically active coordinated metal complex hydrogenation catalysts.

  .beta.-取代-.alpha.-酰胺基丙烯酸催化氢化的均相催化过程，氢化后产生一种光学活性混合物。该过程包括在光学活性配位金属复合物氢化催化剂的存在下，对.beta.-取代-.alpha.-酰胺基丙烯酸进行氢化，其中金属选自铑、铱、钌、锇、钯和铂的群。该过程是任何不对称氢化.beta.-取代-.alpha.-酰胺基丙烯酸的广义过程，其中一种.alpha.-氨基酸对映异构体是期望的最终产品。它特别适用于制备天然存在、具有光学活性并且在不对称中心附着氢的.alpha.-氨基酸。本发明还涉及新的光学活性配位金属复合物氢化催化剂。
• Methylcyclohexyl-O-anisylphosphine
  申请人：Monsanto Company

  公开号：US04294989A1

  公开（公告）日：1981-10-13

  Process for the homogeneous catalytic hydrogenation of .beta.-substituted-.alpha.-acylamido-acrylic acids which yields, after hydrogenation, an optically active mixture. The process comprises the hydrogenation of .beta.-substituted-.alpha.-acylamido-acrylic acids in the presence of an optically active coordinated metal complex hydrogenation catalyst, in which the metal is selected from the group consisting of rhodium, iridium, ruthenium, osmium, palladium and platinum. This process is a generalized process for any asymmetric hydrogenation of .beta.-substituted-.alpha.-acylamido-acrylic acids in which one .alpha.-amino acid enantiomorph is the desired end-product. It is especially useful for the preparation of .alpha.-amino acids found in nature which possess optical activity and which have a hydrogen attached to the asymmetric center. This invention also relates to new optically active coordinated metal complex hydrogenation catalysts.

  .beta.-取代-.alpha.-酰胺基丙烯酸的均相催化氢化过程，氢化后产生一个光学活性混合物。该过程包括在光学活性配位金属催化剂的存在下，氢化.beta.-取代-.alpha.-酰胺基丙烯酸，其中金属选自铑、铱、钌、锇、钯和铂组成的一组。该过程是任何不对称氢化.beta.-取代-.alpha.-酰胺基丙烯酸的广义过程，其中一个.alpha.-氨基酸对映异构体是期望的最终产物。它特别适用于制备天然存在的具有光学活性并在不对称中心附有氢的.alpha.-氨基酸。本发明还涉及新的光学活性配位金属催化剂。
• Metal coordination complexes containing optically active phosphine or
  申请人：Monsanto Company

  公开号：US04124533A1

  公开（公告）日：1978-11-07

  Process for the homogeneous catalytic hydrogenation of .beta.-substituted-.alpha.-acylamido-acrylic acids which yields, after hydrogenation, an optically active mixture. The process comprises the hydrogenation of .beta.-substituted-.alpha.-acylamido-acrylic acids in the presence of an optically active coordinated metal complex hydrogenation catalyst, in which the metal is selected from the group consisting of rhodium, iridium, ruthenium, osmium, palladium and platinum. This process is a generalized process for any asymmetric hydrogenation of .beta.-substituted-.alpha.-acylamido-acrylic acids in which one .alpha.-amino acid enantiomorph is the desired end-product. It is especially useful for the preparation of .alpha.-amino acids found in nature which possess optical activity and which have a hydrogen attached to the asymmetric center. This invention also relates to new optically active coordinated metal complex hydrogenation catalysts.

  .beta.-取代-.alpha.-酰胺基丙烯酸的均相催化氢化过程，经过氢化后，产生一个旋光性混合物。该过程包括在旋光性配位金属复合催化剂的存在下进行.beta.-取代-.alpha.-酰胺基丙烯酸的氢化，其中金属选自铑、铱、钌、锇、钯和铂的群体。该过程是用于任何不对称氢化的.beta.-取代-.alpha.-酰胺基丙烯酸的广义过程，其中一个.alpha.-氨基酸对映异构体是期望的最终产物。它特别适用于制备在自然界中发现的具有光学活性并且在不对称中心处有氢的.alpha.-氨基酸。本发明还涉及新的旋光性配位金属复合催化剂。
• US4124533A
  申请人：——

  公开号：US4124533A

  公开（公告）日：1978-11-07
• US4261919A
  申请人：——

  公开号：US4261919A

  公开（公告）日：1981-04-14