(5-hydroxy-4-oxo-4H-pyran-2-yl)methyl p-chlorobenzoate | 1415033-80-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (5-hydroxy-4-oxo-4H-pyran-2-yl)methyl p-chlorobenzoate
• 英文别名: (5-Hydroxy-4-oxopyran-2-yl)methyl 4-chlorobenzoate；(5-hydroxy-4-oxopyran-2-yl)methyl 4-chlorobenzoate
• CAS: 1415033-80-5
• 化学式: C₁₃H₉ClO₅
• 分子量: 280.664
• InChiKey: IMHNCYRXPYQRID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (4-Oxo-5-phenylmethoxypyran-2-yl)methyl 4-chlorobenzoate 在 palladium on activated charcoal 、 氢气 作用下， 以79%的产率得到(5-hydroxy-4-oxo-4H-pyran-2-yl)methyl p-chlorobenzoate
  参考文献：
  名称：

  A FACILE SYNTHESIS OF (5-HYDROXY-4-OXO-4H-PYRAN-2-YL)METHYL CARBOXYLATES AND THEIR ANTIVIRAL ACTIVITY AGAINST HEPATITIS C VIRUS

  摘要：

  5-Benzyloxy-2-hydroxymethyl-4H-pyran-4-one (2) was synthesized from kojic acid (1) and subsequently reacted with carboxylic anhydride (3a) and a series of carboxylic acid chlorides (3b-l) to give the corresponding (5-benzyloxy-4-oxo-4H-pyran-2-yl)methyl carboxylates (4a-l). These compounds were, then reductively debenzylated to afford the (5-hydroxy-4-oxo-4H-pyran-2-yl)methyl carboxylates (5a-l), which were tested for their inhibitory activities against the hepatitis C virus.

  DOI：

  10.3987/com-13-12726

文献信息

• A FACILE SYNTHESIS OF (5-HYDROXY-4-OXO-4H-PYRAN-2-YL)METHYL CARBOXYLATES AND THEIR ANTIVIRAL ACTIVITY AGAINST HEPATITIS C VIRUS
  作者：Tetsuro Shimo、Yuki Taketsugu、Takuya Goto、Masaaki Toyama、Kohji Yoshimura、Masanori Baba

  DOI：10.3987/com-13-12726

  日期：——

  5-Benzyloxy-2-hydroxymethyl-4H-pyran-4-one (2) was synthesized from kojic acid (1) and subsequently reacted with carboxylic anhydride (3a) and a series of carboxylic acid chlorides (3b-l) to give the corresponding (5-benzyloxy-4-oxo-4H-pyran-2-yl)methyl carboxylates (4a-l). These compounds were, then reductively debenzylated to afford the (5-hydroxy-4-oxo-4H-pyran-2-yl)methyl carboxylates (5a-l), which were tested for their inhibitory activities against the hepatitis C virus.