4-[5-chloro-1-(4-thianthren-1-yl-benzyl)-1H-indol-3-yl]-4-oxo-butyric acid | 792925-54-3

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 4-[5-chloro-1-(4-thianthren-1-yl-benzyl)-1H-indol-3-yl]-4-oxo-butyric acid
• 英文别名: 4-[5-Chloro-1-[(4-thianthren-1-ylphenyl)methyl]indol-3-yl]-4-oxobutanoic acid
• CAS: 792925-54-3
• 化学式: C₃₁H₂₂ClNO₃S₂
• 分子量: 556.106
• InChiKey: GWLOOGDQVLRGGS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  38
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  110
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] SUBSTITUTED HETEROARYLS AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES<br/>[FR] HETEROARYLES SUBSTITUES UTILISES EN TANT QU'INHIBITEURS DES PROTEINE-TYROSINE PHOSPHATASES
  申请人：INST FOR PHARM DISCOVERY INC

  公开号：WO2004099159A1

  公开（公告）日：2004-11-18

  Disclosed are compounds and pharmaceutically acceptable salts of formula (I), which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or hyperglycemia. Compounds of the invention include inhibitors of Protein tyrosine phosphatases, in particular Protein tyrosine phosphatase-1B (PTP-1B), that are useful in the treatment of diabetes and other PTP mediated diseases, such as cancer, neurodegenerative diseases and the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.

  本发明涉及化合物及其药学上可接受的盐，其化学式为（I），用于治疗与胰岛素抵抗、瘦素抵抗或高血糖相关的代谢性疾病。本发明的化合物包括蛋白酪氨酸磷酸酶抑制剂，特别是蛋白酪氨酸磷酸酶-1B（PTP-1B），可用于治疗糖尿病和其他PTP介导的疾病，如癌症、神经退行性疾病等。本发明还涉及包含本发明化合物的制药组合物及使用这些化合物治疗上述疾病的方法。
• Substituted heteroaryls
  申请人：Savoy Jennifer

  公开号：US20050009817A1

  公开（公告）日：2005-01-13

  Disclosed are compounds and pharmaceutically acceptable salts of formula (I): which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or hyperglycemia. Compounds of the invention include inhibitors of Protein tyrosine phosphatases, in particular Protein tyrosine phosphatase-1B (PTP-1B), that are useful in the treatment of diabetes and other PTP mediated diseases, such as cancer, neurodegenerative diseases and the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.

  本发明揭示了式(I)的化合物和药学上可接受的盐，它们在治疗与胰岛素抵抗、瘦素抵抗或高血糖相关的代谢紊乱方面是有用的。本发明的化合物包括蛋白酪氨酸磷酸酶的抑制剂，特别是蛋白酪氨酸磷酸酶-1B（PTP-1B），它们在治疗糖尿病和其他PTP介导的疾病（如癌症、神经退行性疾病等）中是有用的。本发明还揭示了包括本发明化合物的制药组合物以及使用这些化合物治疗上述疾病的方法。
• Heterocycle substituted carboxylic acids
  申请人：Whitehouse Darren

  公开号：US20050004114A1

  公开（公告）日：2005-01-06

  The present invention relates to compounds and pharmaceutically acceptable salts of formula (I): which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or hyperglycemia. Compounds of the invention include inhibitors of Protein tyrosine phosphatases, in particular Protein tyrosine phosphatase-1B (PTP-1B), that are useful in the treatment of diabetes and other PTP mediated diseases, such as cancer, neurodegenerative diseases and the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.

  本发明涉及公式(I)的化合物和药学上可接受的盐，这些化合物在治疗与胰岛素抵抗、瘦素抵抗或高血糖有关的代谢障碍方面是有用的。本发明的化合物包括蛋白酪氨酸磷酸酶抑制剂，特别是蛋白酪氨酸磷酸酶-1B（PTP-1B），这些抑制剂在治疗糖尿病和其他PTP介导的疾病（如癌症、神经退行性疾病等）方面是有用的。本发明还公开了包括本发明的化合物的制药组合物和使用这些化合物治疗上述疾病的方法。
• Heterocycle Substituted Carboxylic Acids
  申请人：Whitehouse Darren

  公开号：US20080146574A1

  公开（公告）日：2008-06-19

  The present invention relates to compounds and pharmaceutically acceptable salts of formula (I): which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or hyperglycemia. Compounds of the invention include inhibitors of Protein tyrosine phosphatases, in particular Protein tyrosine phosphatase-1B (PTP-1B), that are useful in the treatment of diabetes and other PTP mediated diseases, such as cancer, neurodegenerative diseases and the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.

  本发明涉及式（I）的化合物及其药学上可接受的盐，其在治疗与胰岛素抵抗、瘦素抵抗或高血糖有关的代谢障碍方面具有用途。本发明的化合物包括蛋白酪氨酸磷酸酶的抑制剂，特别是蛋白酪氨酸磷酸酶-1B（PTP-1B），这些抑制剂对于治疗糖尿病和其他PTP介导的疾病，如癌症、神经退行性疾病等，是有用的。本发明还揭示了包括本发明化合物的药物组合物和使用这些化合物治疗上述疾病的方法。
• EP1618094A1
  申请人：——

  公开号：EP1618094A1

  公开（公告）日：2006-01-25