6-(3-(3-aminophenyl)-6-(4-methoxyphenyl)-1H-indol-1-yl)-N-(2-morpholinoethyl)pyrimidin-4-amine | 1266727-02-9

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 6-(3-(3-aminophenyl)-6-(4-methoxyphenyl)-1H-indol-1-yl)-N-(2-morpholinoethyl)pyrimidin-4-amine
• 英文别名: 6-[3-(3-aminophenyl)-6-(4-methoxyphenyl)indol-1-yl]-N-(2-morpholin-4-ylethyl)pyrimidin-4-amine
• CAS: 1266727-02-9
• 化学式: C₃₁H₃₂N₆O₂
• 分子量: 520.634
• InChiKey: AFGOWOYDPMLTDE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  39
• 可旋转键数：
  8
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  90.5
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• 1,3,6-SUBSTITUTED INDOLE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASE
  申请人：Sim Tae Bo

  公开号：US20110046370A1

  公开（公告）日：2011-02-24

  Disclosed are a 1,3,6-substituted indole compound having inhibitory activity for protein kinases, a pharmaceutically acceptable thereof, and a pharmaceutical composition for prevention and treatment of diseases caused by abnormal cell growth including the compound as an active ingredient. Since the novel indole compound exhibits superior inhibitory activity for various protein kinases involved in growth factor signal transduction, it is useful as an agent for preventing or treating cancers caused by abnormal cell growth.

  揭示了一种具有蛋白激酶抑制活性的1,3,6-取代吲哚化合物，其药学上可接受，以及一种包含该化合物作为活性成分的用于预防和治疗由异常细胞生长引起的疾病的药物组合物。 由于这种新型吲哚化合物表现出对参与生长因子信号传导的各种蛋白激酶具有优越的抑制活性，因此它可用作预防或治疗由异常细胞生长引起的癌症的药物。
• 1,3,6-Substituted Indole Derivatives Having Inhibitory Activity for Protein Kinase
  申请人：Korea Institute of Science and Technology

  公开号：US20130079343A1

  公开（公告）日：2013-03-28

  Disclosed are a 1,3,6-substituted indole compound having inhibitory activity for protein kinases, a pharmaceutically acceptable thereof, and a pharmaceutical composition for prevention and treatment of diseases caused by abnormal cell growth including the compound as an active ingredient. Since the novel indole compound exhibits superior inhibitory activity for various protein kinases involved in growth factor signal transduction, it is useful as an agent for preventing or treating cancers caused by abnormal cell growth.

  公开了一种具有蛋白激酶抑制活性的1,3,6-取代吲哚化合物，其药学上可接受，以及一种包括该化合物作为活性成分的用于预防和治疗由异常细胞生长引起的疾病的制剂。由于新型吲哚化合物表现出对生长因子信号传导中涉及的各种蛋白激酶的优越抑制活性，因此它可用作预防或治疗由异常细胞生长引起的癌症的药物。
• US8329708B2
  申请人：——

  公开号：US8329708B2

  公开（公告）日：2012-12-11
• US8648089B2
  申请人：——

  公开号：US8648089B2

  公开（公告）日：2014-02-11