N-Isobutyl-taurin | 98961-89-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: N-Isobutyl-taurin
• 英文别名: Isobutyltaurine；2-(2-methylpropylamino)ethanesulfonic acid
• CAS: 98961-89-8
• 化学式: C₆H₁₅NO₃S
• 分子量: 181.256
• InChiKey: MAGRTNDEVAUSLL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  74.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• PD-1/PD-L1 inhibitors
  申请人：Gilead Sciences, Inc.

  公开号：US10710986B2

  公开（公告）日：2020-07-14

  Compounds of Formula (I), methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.

  本研究公开了式（I）化合物、单独使用所述化合物或将其与其他制剂结合使用的方法以及所述化合物用于治疗癌症的组合物。
• Glycopeptide Antibiotic Monomer Derivatives
  申请人：Arimoto Hirokazu

  公开号：US20080097078A1

  公开（公告）日：2008-04-24

  Novel glycopeptide antibiotic derivatives. These derivatives are represented by the formula (aglycon part of glycopeptide antibiotic derivative)-(Sac-NH)—R A [wherein (aglycon part of glycopeptide antibiotic derivative) is the part formed by removing the sugar part from a known glycopeptide antibiotic derivative; (Sac-NH) part is an amino sugar part or a sugar chain part containing an amino sugar; and R A represents, e.g., the formula —X 1 —Ar 1 —X 2 —Y—X 3 —Ar 2 (wherein X 1 , X 2 , and X 3 each represents 1) a single bond or 2) a heteroatom or heteroatom-containing group selected from the group consisting of —N═, ═N—, —NR 1 —, —O—, etc.; Y represents —NR 2 CO— or —CONR 2 — (wherein R 2 represents hydrogen or lower alkyl), etc.)]. These derivatives have antibacterial activity against vancomycin-resistant bacteria.
• PD-1/PD-L1 INHIBITORS
  申请人：Gilead Sciences, Inc.

  公开号：US20190270727A1

  公开（公告）日：2019-09-05

  Compounds of Formula (I), methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.
• US5434276A
  申请人：——

  公开号：US5434276A

  公开（公告）日：1995-07-18
• US7414076B2
  申请人：——

  公开号：US7414076B2

  公开（公告）日：2008-08-19