2,3-dichloro-5-{N-[N-(2-hydroxyethyl)-N-phenylcarbamoylmethyl]-carbamoyl}-4H-thieno[3,2-b]pyrrole | 403859-39-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2,3-dichloro-5-{N-[N-(2-hydroxyethyl)-N-phenylcarbamoylmethyl]-carbamoyl}-4H-thieno[3,2-b]pyrrole
• 英文别名: 2,3-dichloro-N-[2-[N-(2-hydroxyethyl)anilino]-2-oxoethyl]-4H-thieno[3,2-b]pyrrole-5-carboxamide
• CAS: 403859-39-2
• 化学式: C₁₇H₁₅Cl₂N₃O₃S
• 分子量: 412.296
• InChiKey: PGMGZDTWICENIG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  114
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Bicyclic pyrrolyl amides as glucogen phosphorylase inhibitors
  申请人：——

  公开号：US20030232875A1

  公开（公告）日：2003-12-18

  Heterocyclic amide derivatives, of formula (I): wherein —X-Y-Z- is selected from —S—CR 4 ═CR 5 —, —CR 4 ═CR 5 —S—, —O—CR 4 ═CR 5 —, —CR 4 ═CR 5 —O—, —N═CR 4 —S—, —S—CR 4 ═N—, —NR 6 —CR 4 ═CR 5 — and —CR 4 ═CR 5 —NR 6 —; or a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof; (with provisos); possess glycogen phosphorylase inhibitory activity and accordingly have value in the treatment of disease states associated with increased glycogen phosphorylase activity. Processes for the manufacture of said heterocyclic amide derivatives and pharmaceutical compositions containing them are described.

  杂环酰胺衍生物的化学式（I）：其中—X-Y-Z-选择自—S—CR4═CR5—，—CR4═CR5—S—，—O—CR4═CR5—，—CR4═CR5—O—，—N═CR4—S—，—S—CR4═N—，—NR6—CR4═CR5—和—CR4═CR5—NR6—；或其药学上可接受的盐或体内可水解酯；（附带条件）；具有糖原磷酸化酶抑制活性，因此在治疗与糖原磷酸化酶活性增加相关的疾病状态中具有价值。描述了制备所述杂环酰胺衍生物和含有它们的药物组合物的方法。
• BICYCLIC PYRROLYL AMIDES AS GLUCOGEN PHOSPHORYLASE INHIBITORS
  申请人：AstraZeneca AB

  公开号：EP1317459B1

  公开（公告）日：2004-04-07
• N-BIPHENYLCARBONYL- AND N-PHENYLPYRIDYLCARBONYL SUBSTITUTED BI- AND TRICYCLIC AZEPINES AND DIAZEPINES AS VASOPRESSING AGONISTS
  申请人：Wyeth

  公开号：EP1381370A1

  公开（公告）日：2004-01-21
• [EN] N-BIPHENYLCARBONYL- AND N-PHENYLPYRIDYLCARBONYL SUBSTITUTED BI- AND TRICYCLIC AZEPINES AND DIAZEPINES AS VASOPRESSING AGONISTS<br/>[FR] AZEPINES ET DIAZEPINES BI ET TRICYCLIQUES SUBSTITUEES N-BIPHENYLCARBONYLE ET N-PHENYLPYRIDYLCARBONYLE UTILISEES EN TANT QU'AGONISTES DE LA VASOPRESSINE
  申请人：WYETH CORP

  公开号：WO2002083145A1

  公开（公告）日：2002-10-24

  A compound of the formulae (I) or (II): wherein Y is a moiety selected from NR or -(CH2)n; wherein R is hydrogen or (C1-C6) lower alkyl, and n is 1; (Z), represents; (1) a phenyl ring optionally substituted with one or two substituents selected, independently, from the group comprising hydrogen, (C1-C6) lower alkyl, halogen, cyano, CF3, hydroxy, (C1-C6) lower alkoxy, (C1-C6) lower alkoxy carbonyl, carboxy, -CONH2, -CONH[(C1-C6)lower alkyl], -CON[(C1-C6)lower alkyl]2; or (2) a 6-membered aromatic (unsaturated) heterocyclic ring having one nitrogen atom, optionally substituted by (C1-C6) lower alkyl, halogen or (C1-C6) lower alkoxy; (W), represents: (1) a phenyl ring optionally substituted with one or two substituents selected, independently, from the group comprising hydrogen, (C1-C6) lower alkyl, halogen, cyano, CF3, hydroxy, (C1-C6) lower alkoxy, or (C1-C6) lower alkoxy carbonyl, carboxy, -CONH2, -CONH[(C1-C6)lower alkyl], -CON[(C1-C6)lower alkyl]2; or (2) a 5-membered aromatic (unsaturated) heterocyclic ring having one nitrogen atom, optionally substituted by (C1-C6) lower alkyl, (C1-C6) lower alkoxy, or halogen; or (3) a 6-membered aromatic (unsaturated) heterocyclic ring having one nitrogen atom, optionally substituted by (C1-C6) lower alkyl, halogen, or (C1-C6) lower alkoxy, (X), represents a 5-membered aromatic (unsaturated) heterocyclic ring having one sulfur atom, optionally substituted by (C1-C6) lower alkyl, halogen, or (C1-C6) lower alkoxy; R1 is a moiety of Formula (0 or N), and R2, R3, R7, R8 and R9 are, independently, selected from a group consis ting of hydrogen, (C1-C3) lower alkyl, OCH3 halogen, CF3, -SCH3, OCF3, SCF3, or CN; or a pharmaceutically acceptable salt, or pro-drug form thereof.