5-(N-tosylaminomethyl)furfural | 713084-64-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-(N-tosylaminomethyl)furfural
• 英文别名: N-[(5-formylfuran-2-yl)methyl]-4-methylbenzenesulfonamide
• CAS: 713084-64-1
• 化学式: C₁₃H₁₃NO₄S
• mdl: MFCD05998271
• 分子量: 279.317
• InChiKey: VFKLNNNTDQGBDC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  84.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-(N-tosylaminomethyl)furfural 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 以83%的产率得到5-hydroxymethyl-2-(N-tosylaminomethyl)furan
  参考文献：
  名称：

  Synthesis and some transformations of 5-(N-tosylaminomethyl)furfuryl alcohols

  摘要：

  Preparative methods were developed for the synthesis of 5-(N-tosylaminomethyl)furfuryl alcohols, and their behavior during the action of acidic catalysts was studied. It was established that the furan ring of these compounds is stable in the presence of orthophosphoric acid in glacial acetic acid and that their hydroxyl and N-tosylaminomethyl groups are involved in the transformations.

  DOI：

  10.1007/s10593-009-0302-y
• 作为产物：
  描述：

  N,N-二甲基甲酰胺 、 N-tosylfurfurylamine 在 三氯氧磷 作用下， 以84%的产率得到5-(N-tosylaminomethyl)furfural
  参考文献：
  名称：

  Synthesis and some transformations of 5-(N-tosylaminomethyl)furfuryl alcohols

  摘要：

  Preparative methods were developed for the synthesis of 5-(N-tosylaminomethyl)furfuryl alcohols, and their behavior during the action of acidic catalysts was studied. It was established that the furan ring of these compounds is stable in the presence of orthophosphoric acid in glacial acetic acid and that their hydroxyl and N-tosylaminomethyl groups are involved in the transformations.

  DOI：

  10.1007/s10593-009-0302-y

文献信息

• Synthesis and some transformations of 5-(N-tosylaminomethyl)furfuryl alcohols
  作者：T. A. Stroganova、A. V. Butin

  DOI：10.1007/s10593-009-0302-y

  日期：2009.5

  Preparative methods were developed for the synthesis of 5-(N-tosylaminomethyl)furfuryl alcohols, and their behavior during the action of acidic catalysts was studied. It was established that the furan ring of these compounds is stable in the presence of orthophosphoric acid in glacial acetic acid and that their hydroxyl and N-tosylaminomethyl groups are involved in the transformations.