[Pt3(N,N,N',N',N'',N''-hexa(2-pyridyl)-1,3,5-tris(aminomethyl)benzene)(cyclobutane dicarboxylate)3] | 609769-93-9

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: [Pt3(N,N,N',N',N'',N''-hexa(2-pyridyl)-1,3,5-tris(aminomethyl)benzene)(cyclobutane dicarboxylate)3]
• CAS: 609769-93-9
• 化学式: C₅₇H₅₁N₉O₁₂Pt₃
• 分子量: 1639.33
• InChiKey: PFSACNREYXAPBA-UHFFFAOYSA-H

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  N,N,N',N',N'',N''-hexa(2-pyridyl)-1,3,5-tris(aminomethyl)benzene 、 (cyclobutane-1,1-dicarboxylate)bis(dimethylsulfoxide)platinum(II) 以 not given 为溶剂， 以99%的产率得到[Pt3(N,N,N',N',N'',N''-hexa(2-pyridyl)-1,3,5-tris(aminomethyl)benzene)(cyclobutane dicarboxylate)3]
  参考文献：
  名称：

  Toward the Design of Novel Polynuclear Platinum Antitumor Complexes:  A Polydentate Ligand System Based on Dipyridylamine and 1,3,5-Trimethylenebenzene

  摘要：

  A novel hexadentate ligand, N,N,N',N',N',N'-hexa(2-pyridyl)-1,3,5-tris(aminomethyl)benzene (L), was designed and synthesized. The X-ray structure analysis reveals that the three dipyridylamine (DPA) groups of L are almost perpendicular to the central trimethylenebenzene, and two of them are spacially close to each other while the third one is further apart. The trinuclear Pt(II) complexes [Pt3LCl6] (1) and [Pt3L(CBDCA)(3)] (2) (where CBDCA represents cyclobutane dicarboxylic acid) were prepared and fully characterized by IR, NMR, and ESMS spectroscopy. A mononuclear complex, [PtL(CBDCA)] (3), was also prepared and structurally characterized, which suggests that controlled formation of mono-, di-, and trinuclear complexes with L is possible. Spectroscopic data showed that complexes 2 and 3 are able to bind to calf thymus DNA and their CBDCA group can be readily replaced by thiourea.

  DOI：

  10.1021/ic034604q