Ethyl 4-(5-chloro-2-methoxyphenyl)butanoate | 65360-49-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: Ethyl 4-(5-chloro-2-methoxyphenyl)butanoate
• CAS: 65360-49-8
• 化学式: C₁₃H₁₇ClO₃
• 分子量: 256.729
• InChiKey: HZLJDPSSQAPWTK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Ethyl 4-(5-chloro-2-methoxyphenyl)butanoate 、 甲酸乙酯 以58%的产率得到
  参考文献：
  名称：

  WELCH W. M.; PLATTNER J. J.; STRATTEN W. P.; HARBERT C. A., J. MED. CHEM., 1978, 21, NO 3, 257-263

  摘要：

  DOI：
• 作为产物：
  描述：

  乙醇 、 4-(5-氯-2-甲氧基-苯基)-丁酸 在 盐酸 作用下， 生成 Ethyl 4-(5-chloro-2-methoxyphenyl)butanoate
  参考文献：
  名称：

  Analgesic and tranquilizing activity of 5,8-disubstituted 2-aminomethyl-3,4-dihydronaphthalenes

  摘要：

  Interesting analgesic activity approaching that of meperidine and codeine was observed in standard animal models for 8-chloro-3,4-dihydro-5-methoxy-2-pyrrolidinomethylnaphthalene (compound 7). This compound was orally effective and its analgesic activity was not reversed by the opiate antagonist, naloxone. A limited number of other 2-aminomethyl analogues displayed activity in neuroleptic screens.

  DOI：

  10.1021/jm00201a004

文献信息

• Analgesic and tranquilizing activity of 5,8-disubstituted 2-aminomethyl-3,4-dihydronaphthalenes
  作者：Willard M. Welch、J. J. Plattner、Wilford P. Stratten、C. A. Harbert

  DOI：10.1021/jm00201a004

  日期：1978.3

  Interesting analgesic activity approaching that of meperidine and codeine was observed in standard animal models for 8-chloro-3,4-dihydro-5-methoxy-2-pyrrolidinomethylnaphthalene (compound 7). This compound was orally effective and its analgesic activity was not reversed by the opiate antagonist, naloxone. A limited number of other 2-aminomethyl analogues displayed activity in neuroleptic screens.
• WELCH W. M.; PLATTNER J. J.; STRATTEN W. P.; HARBERT C. A., J. MED. CHEM., 1978, 21, NO 3, 257-263
  作者：WELCH W. M.、 PLATTNER J. J.、 STRATTEN W. P.、 HARBERT C. A.

  DOI：——

  日期：——