N-cyclobutyl-2-(2-(2-methoxy-4-morpholinophenylamino)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-ylamino)benzenesulfonamide | 1312162-39-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: N-cyclobutyl-2-(2-(2-methoxy-4-morpholinophenylamino)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-ylamino)benzenesulfonamide
• 英文别名: N-cyclobutyl-2-[[2-(2-methoxy-4-morpholin-4-ylanilino)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]benzenesulfonamide
• CAS: 1312162-39-2
• 化学式: C₂₇H₃₃N₇O₄S
• 分子量: 551.67
• InChiKey: CAJURNHHODPGSF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  39
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  138
• 氢给体数：
  4
• 氢受体数：
  11

文献信息

• Pyridone Derivatives
  申请人：DAIICHI SANKYO COMPANY, LIMITED

  公开号：US20130281428A1

  公开（公告）日：2013-10-24

  Novel compounds or salts thereof, or crystals thereof, which inhibit Axl and are useful for treating diseases caused by Axl hyperfunction, diseases associated with Axl hyperfunction and/or diseases accompanied by Axl hyperfunction are provided. Pyridone derivatives represented by the formula (1) having various substituents or salts thereof, or crystals thereof (where R 1 , R 2 , R 3 , R 5 , R 6 , A, W, X and n in the formula (1) are as defined in the specification, respectively) are provided.

  提供了抑制Axl并用于治疗由Axl高功能引起的疾病、与Axl高功能相关的疾病和/或伴随Axl高功能的疾病的新型化合物或其盐，或其晶体。提供了由式（1）所代表的吡啶酮衍生物，具有各种取代基或其盐，或其晶体（其中式（1）中的R1、R2、R3、R5、R6、A、W、X和n分别如规范中定义）。
• 2,4-DIAMINO-6,7-DIHYDRO-5H-PYRROLO[2,3]PYRIMIDINE DERIVATIVES AS FAK/Pyk2 INHIBITORS
  申请人：Xiao Dengming

  公开号：US20130281438A1

  公开（公告）日：2013-10-24

  The invention relates to a novel class of 2,4-diamino-6,7-dihydro-5H-pyrrolo[2,3]pyrimidine derivatives as a FAK and/or Pyk2 inhibitor, to a process for their preparation, and to a composition thereof, as well as to use of the compounds for the inhibiting FAK and/or Pyk2 and method for the treatment of a FAK and/or Pyk2 mediated disorder or disease.

  本发明涉及一种新型的2,4-二氨基-6,7-二氢-5H-吡咯[2,3]嘧啶衍生物，作为FAK和/或Pyk2抑制剂，以及它们的制备方法、组合物和化合物用于抑制FAK和/或Pyk2以及治疗FAK和/或Pyk2介导的疾病或疾病的方法。
• PYRIDONE DERIVATIVE
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP2810937B1

  公开（公告）日：2016-11-30
• US8933103B2
  申请人：——

  公开号：US8933103B2

  公开（公告）日：2015-01-13
• US9428508B2
  申请人：——

  公开号：US9428508B2

  公开（公告）日：2016-08-30