N-benzyl-4-(morpholine-4-carbonyl)benzamide | 1437785-89-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-benzyl-4-(morpholine-4-carbonyl)benzamide
• CAS: 1437785-89-1
• 化学式: C₁₉H₂₀N₂O₃
• 分子量: 324.379
• InChiKey: FXOYGHKOUWSTLV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  一氧化碳 、 4-(吗啉-4-羰基)溴苯 、 苄胺 在 potassium carbonate 、 双(2-二苯基磷苯基)醚 作用下， 以 甲苯 为溶剂， 105.0 ℃ 、400.01 kPa 条件下， 反应 12.0h， 以72%的产率得到N-benzyl-4-(morpholine-4-carbonyl)benzamide
  参考文献：
  名称：

  Palladium Nanoparticles Supported on ZIF-8 As an Efficient Heterogeneous Catalyst for Aminocarbonylation

  摘要：

  Pd nanoparticles supported on ZIF-8 (PdNPs/ZIF-8) are described as an efficient heterogeneous catalyst for the aminocarbonylation of bromoarenes in the presence of phosphines and iodoarenes under phosphine-free conditions. The catalyst can be readily prepared and is air-stable. The palladium loading can be as low as 1 wt %, and the catalyst was recycled four times with negligible change in catalytic performance. A variety of pharmaceutically important amides was readily synthesized. A TON of 2540 was easily achieved in a batch reaction by scaling up to a gram scale. The catalyst reported can also be applied to the synthesis of cyclic and primary amides as well as an alkoxycarbonylation reaction to form an ester.

  DOI：

  10.1021/cs400232b

文献信息

• Palladium Nanoparticles Supported on ZIF-8 As an Efficient Heterogeneous Catalyst for Aminocarbonylation
  作者：Tuan T. Dang、Yinghuai Zhu、Joyce S. Y. Ngiam、Subhash C. Ghosh、Anqi Chen、Abdul M. Seayad

  DOI：10.1021/cs400232b

  日期：2013.6.7

  Pd nanoparticles supported on ZIF-8 (PdNPs/ZIF-8) are described as an efficient heterogeneous catalyst for the aminocarbonylation of bromoarenes in the presence of phosphines and iodoarenes under phosphine-free conditions. The catalyst can be readily prepared and is air-stable. The palladium loading can be as low as 1 wt %, and the catalyst was recycled four times with negligible change in catalytic performance. A variety of pharmaceutically important amides was readily synthesized. A TON of 2540 was easily achieved in a batch reaction by scaling up to a gram scale. The catalyst reported can also be applied to the synthesis of cyclic and primary amides as well as an alkoxycarbonylation reaction to form an ester.