A 21-substituted steroid compound is disclosed. The compound has a structure of formula (I),
wherein R¹ is a hydrogen atom, a lower alkyl, lower alkenyl, lower alkoxy, or phenyl group, R² is a hydroxyl group or an acyloxy group having 1-6 carbon atoms, R³ is a hydrogen atom or a lower alkyl group, or R² and R³ may together form a lower alkylidenedioxy group, X¹ and X² may be the same or different and individually represents a hydrogen atom or a halogen atom, Y¹ and Y² may be the same or different and individually represents a methylene group or a sulfur atom, Z is a sulfur atom or an imino group, the wave line means that the configuration of R³ may be of either α or β, and dotted line between the 1 and 2 position means that the bond may be the double bond. It has excellent anti-inflammatory, anti-allergic and anti-asthma activities with little side effects, and is useful for the prevention, cure, and treatment of on inflammation, allergic diseases, rheumatism, and the like.
本发明公开了一种 21 取代类
固醇化合物。该化合物具有式 (I) 结构、
其中 R¹ 是氢原子、低级烷基、低级烯基、低级烷氧基或苯基,R² 是羟基或具有 1-6 个碳原子的酰氧基,R³ 是氢原子或低级烷基,或 R² 和 R³ 可共同形成低级亚烷基二氧基,X¹ 和 X² 可以相同或不同,各自代表氢原子或卤素原子、波浪线表示 R³ 的构型可以是 α 或 β,1 和 2 之间的虚线表示键可以是双键。它具有极佳的抗炎、抗过敏和抗哮喘活性,且副作用小,可用于预防、治疗和治疗炎症、过敏性疾病、风湿病等。