3-[5-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamino]-benzonitrile | 1454654-63-7

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 3-[5-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamino]-benzonitrile
• 英文别名: 3-[[5-(1-Methylpyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-yl]amino]benzonitrile
• CAS: 1454654-63-7
• 化学式: C₁₆H₁₂N₈
• 分子量: 316.325
• InChiKey: WIKYGADCNUEXAF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  96.7
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] TRIAZOLOPYRAZINE DERIVATIVES<br/>[FR] DÉRIVÉS DE TRIAZOLOPYRAZINE
  申请人：MERCK PATENT GMBH

  公开号：WO2013131609A1

  公开（公告）日：2013-09-12

  Compounds of the formula (I) in which R1, R2 and R4 have the meanings indicated in Claim 1, are inhibitors of GCN2, and can be employed, inter alia, for the treatment of cancer.

  式(I)中R1、R2和R4具有权利要求1中所指示的含义的化合物是GCN2的抑制剂，可用于治疗癌症。
• TRIAZOLOPYRAZINE DERIVATIVES
  申请人：Merck Patent GmbH

  公开号：US20150051202A1

  公开（公告）日：2015-02-19

  Compounds of the formula I in which R 1 , R 2 and R 4 have the meanings indicated in Claim 1, are inhibitors of GCN2, and can be employed, inter alia, for the treatment of cancer.

  公式I中，R1、R2和R4的含义如权利要求1所示的化合物是GCN2的抑制剂，可以用于治疗癌症等疾病。
• DEGRADABLE FLUID SEALING COMPOSITIONS HAVING AN ADJUSTABLE DEGRADATION RATE AND METHODS FOR USE THEREOF
  申请人：Halliburton Energy Services, Inc.

  公开号：EP2823014A1

  公开（公告）日：2015-01-14
• [EN] DEGRADABLE FLUID SEALING COMPOSITIONS HAVING AN ADJUSTABLE DEGRADATION RATE AND METHODS FOR USE THEREOF<br/>[FR] COMPOSITIONS FORMANT UNE ÉTANCHÉITÉ AUX FLUIDES DÉGRADABLE, PRÉSENTANT UNE VITESSE DE DÉGRADATION RÉGLABLE, ET LEURS PROCÉDÉS D'UTILISATION
  申请人：HALLIBURTON ENERGY SERV INC

  公开号：WO2013134014A1

  公开（公告）日：2013-09-12

  When performing subterranean treatment operations, it can be desirable to temporarily divert or block fluid flow by forming a degradable fluid seal. Methods for forming a degradable fluid seal can comprise: providing a sealing composition comprising : a degradable polymer, and a water-soluble material comprising a first portion and a second portion of rigid particulates, each portion having a sealing time and a particulate size distribution associated therewith, the particulate size distributions of the first portion and the second portion differing from one another; determining an amount of the first portion relative to the second portion needed to produce a degradable fluid seal having a desired sealing time that is different than that of the sealing time of either the first portion or the second portion; introducing the sealing composition into a subterranean formation; and allowing the sealing composition to form a degradable fluid seal in the subterranean formation.