聚(7-去氮杂鸟苷酸) | 82513-50-6

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 吡咯并嘧啶核苷和核苷酸
• 中文名称: 聚(7-去氮杂鸟苷酸)
• 中文别名: 4-[(2S,3R)-2-羧基-3-羟基吖丁啶-1-基]-N-[(3S)-3-羧基-3-羟基丙基]-L-阿洛苏氨酸
• 英文名称: Poly(7-deazaguanylic acid)
• 英文别名: [(2R,3S,4R,5R)-5-(2-amino-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
• CAS: 82513-50-6
• 化学式: C₁₁H₁₅N₄O₈P
• 分子量: 362.23
• InChiKey: PRWBQQDXKZTQJR-DAGMQNCNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.1
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  189
• 氢给体数：
  6
• 氢受体数：
  8

文献信息

• MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF
  申请人：MODERNA THERAPEUTICS, INC.

  公开号：US20150307542A1

  公开（公告）日：2015-10-29

  The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using them.

  本公开提供了修改的核苷酸，核苷酸和核酸，以及使用它们的方法。
• MODIFIED NUCLEOSIDE, NUCLEOTIDE, AND NUCLEIC ACID COMPOSITIONS
  申请人：MODERNA THERAPEUTICS

  公开号：US20130266640A1

  公开（公告）日：2013-10-10

  The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and/or activity.
• FORMULATION AND DELIVERY OF PLGA MICROSPHERES
  申请人：MODERNA THERAPEUTICS

  公开号：US20130252281A1

  公开（公告）日：2013-09-26

  The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and/or activity.
• MODIFIED POLYNUCLEOTIDES ENCODING APOPTOSIS INDUCING FACTOR 1
  申请人：Bancel Stephane

  公开号：US20140107189A1

  公开（公告）日：2014-04-17

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncology-related polynucleotides, oncology-related primary transcripts and oncology-related mmRNA molecules.