2-(fluoromethyl)cyclobutane-1-carboxylic acid | 1421602-02-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(fluoromethyl)cyclobutane-1-carboxylic acid
• CAS: 1421602-02-9
• 化学式: C₆H₉FO₂
• mdl: MFCD22392068
• 分子量: 132.135
• InChiKey: JSBNCJNDZUIZTP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(fluoromethyl)cyclobutane-1-carboxylic acid 、 N-((R)-1-(2-((S)-amino(4,4-difluorocyclohexyl)methyl)-1H-benzo[d]imidazol-5-yl)ethyl)-4,4,4-trifluorobutanamide 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 作用下， 以 乙腈 为溶剂， 生成 cis-(1,2)-N-((S)-(4,4-difluorocyclohexyl)(5-((R)-1-(4,4,4-trifluorobutanamido)ethyl)-1H-benzo[d]imidazol-2-yl)methyl)-2-(fluoromethyl)cyclobutane-1-carboxamide 、 trans-(1,2)-N-((S)-(4,4-difluorocyclohexyl)(5-((R)-1-(4,4,4-trifluorobutanamido)ethyl)-1H-benzo[d]imidazol-2-yl)methyl)-2-(fluoromethyl)cyclobutane-1-carboxamide
  参考文献：
  名称：

  [EN] BENZIMIDAZOLES AS MODULATORS OF IL-17
  [FR] BENZIMIDAZOLES UTILISÉS EN TANT QUE MODULATEURS D'IL-17

  摘要：

  The present application discloses compounds of Formula (I): (I), or pharmaceutically acceptable salt thereof, wherein R1, R2, R3, and R4are defined in the specification, as well as methods of making and using the compounds disclosed herein for treating or ameliorating an IL-17 mediated syndrome, disorder and/or disease.

  公开号：

  WO2023049888A1

文献信息

• Cycloalkyl substituted triazole compounds as agonists of the APJ receptor
  申请人：AMGEN INC.

  公开号：US11020395B2

  公开（公告）日：2021-06-01

  Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: (I) (II) where the definitions of the variables are provided herein.

  式 I 和式 II 的化合物、其药学上可接受的盐、前述任何化合物的立体异构体或其混合物是 APJ 受体的激动剂，可用于治疗心血管疾病和其他疾病。式 I 和式 II 的化合物具有如下结构：(I) (II) 变量的定义见本文。
• CYCLOALKYL SUBSTITUTED TRIAZOLE COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR
  申请人：AMGEN INC.

  公开号：US20190290648A1

  公开（公告）日：2019-09-26

  Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: (I) (II) where the definitions of the variables are provided herein.