6-amino-N-methyl-N-(2-morpholinoethoxy)hexane-1-sulfonamide | 1170232-33-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 6-amino-N-methyl-N-(2-morpholinoethoxy)hexane-1-sulfonamide
• 英文别名: 6-amino-N-methyl-N-(2-morpholin-4-ylethoxy)hexane-1-sulfonamide
• CAS: 1170232-33-3
• 化学式: C₁₃H₂₉N₃O₄S
• 分子量: 323.457
• InChiKey: DXQWOCRCJMNAND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  21
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  93.5
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• [EN] NOVEL CYANOGUANIDINES<br/>[FR] NOUVELLES CYANOGUANIDINES
  申请人：TOPOTARGET AS

  公开号：WO2009086835A1

  公开（公告）日：2009-07-16

  This application discloses novel cyanoguanidines of the formula (I) wherein A is selected from -C(=O)-, -S(=O)2-, -C(=S)-, and -P(=O)(R5)-, wherein R5 is selected from C1-6-alkyl, C1-6-alkoxy, and hydroxy; B is selected from a single bond, -O-, -NR6- and -C(=O)-NR6-, wherein R6 is selected from hydrogen, optionally substituted C1-12-alkyl, optionally substituted C1-12-alkenyl, optionally substituted aryl, optionally substituted heterocyclyl, and optionally substituted heteroaryl; and m is an integer of 0-12 and n is an integer of 0-12, wherein the sum m+n is 1-20; and R1 is selected from optionally substituted heteroaryl; and pharmaceutically acceptable salts thereof, and prodrugs thereof. The compounds are usefuld for use as a medicament for the treatment of a disease or a condition caused by an elevated level of nicotinamide phosphoribosyltransferase (NAMPRT).

  该申请公开了一种新型氰胍啶化合物，其化学式为（I），其中A从-C（=O）-，-S（=O）2-，-C（=S）-和-P（=O）（R5）-中选择，其中R5选择自C1-6-烷基，C1-6-烷氧基和羟基；B从单键，-O-，-NR6-和-C（=O）-NR6-中选择，其中R6选择自氢，可选择地取代的C1-12-烷基，可选择地取代的C1-12-烯基，可选择地取代的芳基，可选择地取代的杂环烷基和可选择地取代的杂环芳基；m为0-12的整数，n为0-12的整数，其中m+n之和为1-20；R1选择自可选择地取代的杂环芳基；以及其药学上可接受的盐和前药。这些化合物可用作治疗由烟酰胺磷酸核糖转移酶（NAMPRT）水平升高引起的疾病或病况的药物。
• SQUARIC ACID DERIVATIVES AS INHIBITORS OF THE NICOTINAMIDE
  申请人：Christensen Mette Knak

  公开号：US20120225847A1

  公开（公告）日：2012-09-06

  The present application discloses novel squaric acid derivatives of the formula A: from —C(═O)—, —S(═O) 2 —, —C(═S)— and —P(═O)(R 5 )—; B: -, —O—, —NR 6 — and —C(═O)—NR 6 —; D: -, —O—, —CR 7 R 8 — and —NR 9 ; m=0-12; n=0-12; m+n=1-20; p=0-2; R 1 : heteroaryl, aryl; R 2 : H, C 1-12 -alkyl, C 3-12 -cycloalkyl, —[CH 2 CH 2 O] 1-10 —(C 1-6 -alkyl), C 1-12 -alkenyl, aryl, heterocyclyl, heteroaryl; R 3 : C 1-12 -alkyl, C 3-12 -cycloalkyl, —[CH 2 CH 2 O] 1-10 —(C 1-6 -alkyl), C 1-12 -alkenyl, aryl, heterocyclyl, heteroaryl; or R 2 and R 3 : N-containing heterocyclic/heteroaromatic ring; R 4 and R 4 *: H, C 1-12 -alkyl, C 1-12 -alkenyl; and pharmaceutically acceptable salts and prodrugs thereof, and their use in the treatment of diseases/conditions caused by an elevated level of NAMPRT (inflammatory and tissue repair disorders, particularly rheumatoid arthritis, inflammatory bowel disease, asthma and CPOD, osteoarthritis, osteoporosis and fibrotic diseases; dermatosis; autoimmune diseases including systemic lupus erythematosis, multiple sclerosis, psoriatic arthritis, ankylosing spondylitis, tissue and organ rejection, Alzheimer's disease, stroke, atherosclerosis, restenosis, diabetes, glomerulonephritis, cancer, cachexia, inflammation associated with infection and viral infections, adult respiratory distress syndrome, ataxia telengiectasia).

  本申请公开了公式A的新型苯二甲酸衍生物：从—C（═O）—，—S（═O）2—，—C（═S）—和—P（═O）（R5）—；B：-，—O—，—NR6—和—C（═O）—NR6—；D：-，—O—，—CR7R8—和—NR9；m=0-12；n=0-12；m+n=1-20；p=0-2；R1：杂环芳基，芳基；R2：H，C1-12-烷基，C3-12-环烷基，—[CH2CH2O]1-10—（C1-6-烷基），C1-12-烯基，芳基，杂环烷基，杂环芳基；R3：C1-12-烷基，C3-12-环烷基，—[CH2CH2O]1-10—（C1-6-烷基），C1-12-烯基，芳基，杂环烷基，杂环芳基；或R2和R3：含氮杂环/杂芳基环；R4和R4*：H，C1-12-烷基，C1-12-烯基；以及其药学上可接受的盐和前药，以及它们在治疗由NAMPRT水平升高引起的疾病/状况中的用途（炎症和组织修复障碍，特别是类风湿性关节炎，炎症性肠病，哮喘和CPOD，骨关节炎，骨质疏松症和纤维性疾病；皮肤病；自身免疫性疾病，包括系统性红斑狼疮，多发性硬化症，银屑病性关节炎，强直性脊柱炎，组织和器官排斥，阿尔茨海默病，中风，动脉粥样硬化，再狭窄，糖尿病，肾小球肾炎，癌症，消瘦症，与感染和病毒感染相关的炎症，成人呼吸窘迫综合征，遗传性毛细血管扩张性共济失调）。
• PROPYLENE RESIN COMPOSITION
  申请人：KONDO Shinichi

  公开号：US20120225994A1

  公开（公告）日：2012-09-06

  Disclosed is a propylene resin composition from which a molded article maintaining mechanical properties of conventional molded articles and being superior in scratch can be produced, the composition including from 60% by mass to 99% by mass of a propylene resin (A), from 1% by mass to 40% by mass of a filler (B1) having a pH of from 9 to 14, and from 0.01 parts by mass to 5 parts by mass, relative to 100 parts by mass of the (A) and the (B1) in total, of a modified olefin resin (C1) obtained by reacting an olefin resin, an acidic compound having at least one unsaturated bond and at least one kind of polar group and having a pH of higher than 0 and up to 4, and an organic peroxide.
• Coated, Wet-Chemically Oxidized Aluminum Effect Pigments, Method for the Production Thereof, Coating Agent and Coated Object
  申请人：Eckart GmbH

  公开号：US20150098972A1

  公开（公告）日：2015-04-09

  A coated wet-chemically oxidized aluminum effect pigment is provided having at least one metal oxide layer having at least one metal oxide which differs from aluminum oxide and an enveloping organic polymer layer, wherein the weight ratio of the metal oxide of the metal oxide layer to aluminum oxide in the wet-chemically produced aluminum oxide layer of uncoated wet-chemically oxidized aluminum effect pigment is in a range of from 1:1 to 1:40. Also, a method for the production of the pigment is provided.
• US9006426B2
  申请人：——

  公开号：US9006426B2

  公开（公告）日：2015-04-14