N-dodecyl-N'-methyl-thiourea | 6430-76-8

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫脲类
• 英文名称: N-dodecyl-N'-methyl-thiourea
• 英文别名: N-Dodecyl-N'-methyl-thioharnstoff；1-Dodecyl-3-methylthiourea
• CAS: 6430-76-8
• 化学式: C₁₄H₃₀N₂S
• 分子量: 258.472
• InChiKey: SPDAWXYKSXNSMH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  17
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  25.4
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-dodecyl-N'-methyl-thiourea 、 碘甲烷 以 丙酮 为溶剂， 生成 1-Dodecyl-2,3-dimethyl-isothiourea
  参考文献：
  名称：

  BE626015

  摘要：

  公开号：
• 作为产物：
  描述：

  十二烷基伯胺 、 异硫氰酸甲酯 在 苯 作用下， 生成 N-dodecyl-N'-methyl-thiourea
  参考文献：
  名称：

  Notes - Reactions of Long-Chain Amines. VI. Preparation of Thioureas

  摘要：

  DOI：

  10.1021/jo01110a611

文献信息

• Transdermal Pharmaceutical Compositions Including Testosterone and a C-SERM
  申请人：Professional Compounding Centers of America (PCCA)

  公开号：US20160051498A1

  公开（公告）日：2016-02-25

  Formulations for transdermal pharmaceutical compositions including a synergistic combination of low doses of testosterone with a selective estrogen receptor modulator (C-SERM) that are combined with transdermal permeation enhancers are disclosed. Transdermal pharmaceutical compositions can be designed with various release rates, and can be administered to increase bloodstream testosterone levels and thereby reduce symptoms of testosterone deficiency. Transdermal pharmaceutical compositions include liquid dosage forms, such as, for example solutions, liquid sprays, lotions, and the like. Additionally, transdermal pharmaceutical compositions include semi-solid dosage forms, such as, for example emulsions, creams, gels, pastes, ointments, and the like. Transdermal pharmaceutical compositions will deliver testosterone and C-SERM through the skin and directly into the patient's bloodstream, thereby providing high bioavailability of testosterone and C-SERM. The dosage regimen of the transdermal pharmaceutical compositions can be easily tailored for individual patients according to the baseline blood levels of testosterone and estradiol.
• Transdermal Pharmaceutical Compositions Including C-SERMs for Low Testosterone Levels in Men
  申请人：Professional Compounding Centers of America (PCCA)

  公开号：US20160051497A1

  公开（公告）日：2016-02-25

  Formulations for transdermal pharmaceutical compositions including clomiphene-like selective estrogen receptor modulators (C-SERMs) in combination with transdermal penetration enhancers are disclosed. Transdermal pharmaceutical compositions can be designed with various release rates, and are administered to increase bloodstream testosterone levels and thereby reduce symptoms of testosterone deficiency in male hypogonadism or male infertility. Transdermal pharmaceutical compositions include a range of dosage forms, such as, for example solutions, liquid sprays, lotions, emulsions, creams, pastes, and ointments, among other dosage forms that exhibit transdermal properties, and provide transdermal delivery of C-SERMs. Transdermal pharmaceutical compositions will deliver C-SERMs through the skin and directly into the patient's bloodstream, thereby providing high bioavailability of C-SERMs. The dosage regimen of the transdermal pharmaceutical compositions can be easily tailored for individual patients according to the baseline blood levels of testosterone and estradiol.
• Transdermal Pharmaceutical Compositions Including Testosterone and an Aromatase Inhibitor
  申请人：Professional Compounding Centers of America (PCCA)

  公开号：US20160051565A1

  公开（公告）日：2016-02-25

  Formulations for transdermal pharmaceutical compositions including a synergistic combination of low doses of testosterone with an aromatase inhibitor (AI) that are combined with transdermal permeation enhancers are disclosed. Transdermal pharmaceutical compositions can be designed with various release rates, and can be administered to increase bloodstream testosterone levels and thereby reduce symptoms of testosterone deficiency. Transdermal pharmaceutical compositions include liquid dosage forms, such as, for example solutions, liquid sprays, lotions, and the like. Additionally, transdermal pharmaceutical compositions include semi-solid dosage forms, such as, for example emulsions, creams, gels, pastes, ointments, and the like. Transdermal pharmaceutical compositions will deliver testosterone and AI through the skin and directly into the patient's bloodstream, thereby providing high bioavailability of testosterone and AI. The dosage regimen of the transdermal pharmaceutical compositions can be easily tailored for individual patients according to the baseline blood levels of testosterone and estradiol.
• USE OF SULFUR AND SELENIUM COMPOUNDS AS PRECURSORS TO NANOSTRUCTURED MATERIALS
  申请人：THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

  公开号：US20160237345A1

  公开（公告）日：2016-08-18

  The presently disclosed subject matter provides processes for preparing nanocrystals, including processes for preparing core-shell nanocrystals. The presently disclosed subject matter also provides sulfur and selenium compounds as precursors to nanostructured materials. The presently disclosed subject matter also provides nanocrystals having a particular particle size distribution.
• Integumentary System Therapy
  申请人：Lebovitz Russell M.

  公开号：US20170050044A1

  公开（公告）日：2017-02-23

  Described are methods, kits, apparatus, and compositions for integumentary system therapy. For example, a method for therapy may include providing a subject in need of therapy for a condition. The condition may be associated with a substrate located in the subject's integumentary system. The method may include contacting a therapeutic agent and the substrate in the subject's integumentary system. The method may include modulating a depth of at least one ionic species in the subject's integumentary system. The at least one ionic species may include one or more of: the therapeutic agent; a bound therapeutic agent:substrate complex; and a reaction product of one or both of the therapeutic agent and the substrate. The method may be effective to at least partly ameliorate the condition in the subject.