2-(2,6-dimethylphenyl)-4-methylpyridine | 1335136-61-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(2,6-dimethylphenyl)-4-methylpyridine
• 英文别名: 2-(2,6-dimethylphenyl)-5-methylpyridine
• CAS: 1335136-61-2
• 化学式: C₁₄H₁₅N
• 分子量: 197.28
• InChiKey: QJFFVRAXCFYMEY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  5-甲基-2-(4,4,5,5-四甲基-1,3,2-二噁硼烷-2-基)吡啶 、 2,6-二甲基溴苯 在 2-双环己基膦-2',6'-二甲氧基联苯 、 palladium diacetate 、 caesium carbonate 、 copper(l) chloride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 以58%的产率得到2-(2,6-dimethylphenyl)-4-methylpyridine
  参考文献：
  名称：

  Expanding the scope of the Cu assisted Suzuki–Miyaura reaction

  摘要：

  Recent advances in the development of the copper facilitated Suzuki-Miyaura reaction are described. Improvements include expansion of substrate scope to include aryl chlorides and polyhalo aryl boronates. It was found that use of S-Phos and X-Phos could accomplish the coupling of 2-pyridyl boronates to aryl chlorides and bromides in shorter reaction times and in higher yield than previously described with DPPF. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.07.088

文献信息

• Palladium-Catalyzed Electrochemical C–H Alkylation of Arenes
  作者：Qi-Liang Yang、Chuan-Zeng Li、Liang-Wei Zhang、Yu-Yan Li、Xiaofeng Tong、Xin-Yan Wu、Tian-Sheng Mei

  DOI：10.1021/acs.organomet.8b00550

  日期：2019.3.25

  electrochemical C–H functionalization reactions have emerged as attractive tools for organic synthesis. This process offers an alternative to conventional methods that require harsh chemical oxidants. However, this electrolysis requires divided cells to avoid catalyst deactivation by cathodic reduction. Herein, we report the first example of palladium-catalyzed electrochemical C–H alkylation of arenes using

  钯催化的电化学C–H官能化反应已成为有机合成的诱人工具。该方法为需要苛刻化学氧化剂的常规方法提供了一种替代方法。然而，这种电解需要分裂的电池以避免通过阴极还原使催化剂失活。在这里，我们报告了使用未拆分的电化学池在水中钯催化的芳烃电化学C–H烷基化的第一个例子，从而为将烷基引入芳烃提供了实用的解决方案。
• ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES
  申请人：Universal Display Corporation

  公开号：US20200295277A1

  公开（公告）日：2020-09-17

  Provided are organometallic compounds. Also provided are formulations comprising these organometallic compounds. Further provided are OLEDs and related consumer products that utilize these organometallic compounds.