3-benzo[1,3]dioxol-5-yl-5-hydroxy-5-[4-(2-bromoethoxy)-phenyl]-4-(3,4,5-trimethoxybenzyl)-5H-furan-2-one | 1196878-66-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: 3-benzo[1,3]dioxol-5-yl-5-hydroxy-5-[4-(2-bromoethoxy)-phenyl]-4-(3,4,5-trimethoxybenzyl)-5H-furan-2-one
• 英文别名: 3-(1,3-benzodioxol-5-yl)-5-[4-(2-bromoethoxy)phenyl]-5-hydroxy-4-[(3,4,5-trimethoxyphenyl)methyl]furan-2-one
• CAS: 1196878-66-6
• 化学式: C₂₉H₂₇BrO₉
• 分子量: 599.432
• InChiKey: NJYBLOBYXABWFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  39
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  102
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  3-benzo[1,3]dioxol-5-yl-5-hydroxy-5-[4-(2-bromoethoxy)-phenyl]-4-(3,4,5-trimethoxybenzyl)-5H-furan-2-one 、 silver(I) 4-methylbenzenesulfonate 以 乙腈 为溶剂， 反应 17.0h， 以82%的产率得到2-{4-[4-(benzo[1,3]dioxol-5-yl)-2-hydroxy-5-oxo-3-(3,4,5-trimethoxybenzyl)-2,5-dihydro-furan-2-yl]phenoxy}ethyl 4-methylbenzenesulfonate
  参考文献：
  名称：

  PET-compatible endothelin receptor radioligands: Synthesis and first in vitro and in vivo studies

  摘要：

  The expression and function of endothelin (ET) receptors is abnormal in cardiovascular diseases, tumor progression, and tumor metastasis. In this study, we prepared two [F-18]-fluorinated derivatives of the non-peptide ETA receptor antagonist PD 156707 and evaluated their ET receptor binding potencies. Ex vivo as well as in vivo biodistribution studies in mice were performed, as well as the metabolism of the radiotracer, which was examined by metabolite analysis in mice and rats. All tested derivatives of PD 156707 exhibited potent in vitro pharmacological characteristics with K-i values comparable to that of the lead compound. The biodistribution studies showed a high accumulation of the tracer in bile and intestine. In vivo we were able to show that the visualization of the heart as a major target organ with high ETAR expression is possible. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.08.058
• 作为产物：
  描述：

  2-(1,3-benzodioxol-5-yl)-1-[4-(2-bromoethoxy)phenyl]-4-oxobutyric acid methyl ester 、 3,4,5-三甲氧基苯甲醛 在 sodium methylate 、 溶剂黄146 作用下， 以 甲醇 为溶剂， 反应 30.0h， 以41%的产率得到3-benzo[1,3]dioxol-5-yl-5-hydroxy-5-[4-(2-bromoethoxy)-phenyl]-4-(3,4,5-trimethoxybenzyl)-5H-furan-2-one
  参考文献：
  名称：

  PET-compatible endothelin receptor radioligands: Synthesis and first in vitro and in vivo studies

  摘要：

  The expression and function of endothelin (ET) receptors is abnormal in cardiovascular diseases, tumor progression, and tumor metastasis. In this study, we prepared two [F-18]-fluorinated derivatives of the non-peptide ETA receptor antagonist PD 156707 and evaluated their ET receptor binding potencies. Ex vivo as well as in vivo biodistribution studies in mice were performed, as well as the metabolism of the radiotracer, which was examined by metabolite analysis in mice and rats. All tested derivatives of PD 156707 exhibited potent in vitro pharmacological characteristics with K-i values comparable to that of the lead compound. The biodistribution studies showed a high accumulation of the tracer in bile and intestine. In vivo we were able to show that the visualization of the heart as a major target organ with high ETAR expression is possible. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.08.058

文献信息

• PET-compatible endothelin receptor radioligands: Synthesis and first in vitro and in vivo studies
  作者：Carsten Höltke、Marilyn P. Law、Stefan Wagner、Klaus Kopka、Andreas Faust、Hans-Jörg Breyholz、Otmar Schober、Christoph Bremer、Burkhard Riemann、Michael Schäfers

  DOI：10.1016/j.bmc.2009.08.058

  日期：2009.10

  The expression and function of endothelin (ET) receptors is abnormal in cardiovascular diseases, tumor progression, and tumor metastasis. In this study, we prepared two [F-18]-fluorinated derivatives of the non-peptide ETA receptor antagonist PD 156707 and evaluated their ET receptor binding potencies. Ex vivo as well as in vivo biodistribution studies in mice were performed, as well as the metabolism of the radiotracer, which was examined by metabolite analysis in mice and rats. All tested derivatives of PD 156707 exhibited potent in vitro pharmacological characteristics with K-i values comparable to that of the lead compound. The biodistribution studies showed a high accumulation of the tracer in bile and intestine. In vivo we were able to show that the visualization of the heart as a major target organ with high ETAR expression is possible. (C) 2009 Elsevier Ltd. All rights reserved.