4-氯-2-(4-氯-苯基硫烷基)-苯胺 | 105836-84-8

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 中文名称: 4-氯-2-(4-氯-苯基硫烷基)-苯胺
• 英文名称: 4-chloro-2-(4-chlorophenylthio)aniline
• 英文别名: 4-chloro-2-(4-chloro-phenylsulfanyl)-aniline；4-Chlor-2-(4-chlor-phenylmercapto)-anilin；4-chloro-2-(4-chlorophenylsulfanyl)phenylamine；4-chloro-2-(4-chlorophenyl)sulfanylaniline
• CAS: 105836-84-8
• 化学式: C₁₂H₉Cl₂NS
• 分子量: 270.182
• InChiKey: ROXQIHFBPFWZMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  51.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-氯-2-(4-氯-苯基硫烷基)-苯胺 在 lithium aluminium tetrahydride 作用下， 生成 N'-[4-chloro-2-(4-chloro-phenylsulfanyl)-phenyl]-N,N-dimethyl-propanediyldiamine
  参考文献：
  名称：

  Chlorinated o-Dimethylaminopropylaminodiphenyl Sulfide Derivatives

  摘要：

  DOI：

  10.1021/jo01118a013
• 作为产物：
  描述：

  3,4-二硝基氯苯 在 sodium hydroxide 、 乙醇 、 镍 、 一水合肼 作用下， 反应 2.0h， 生成 4-氯-2-(4-氯-苯基硫烷基)-苯胺
  参考文献：
  名称：

  Chlorinated o-Dimethylaminopropylaminodiphenyl Sulfide Derivatives

  摘要：

  DOI：

  10.1021/jo01118a013

文献信息

• Control of parasites in animals by N-[(phenyloxy)phenyl]-1,1,1-trifluoromethanesulfonamide and N-[(phenylsulfanyl)phenyl]-1,1,1-trifluoromethanesulfonamide derivatives
  申请人：Meyer Gerhard Adam

  公开号：US20060281695A1

  公开（公告）日：2006-12-14

  Methods for treating an animal for endo and/or ecto parasite infestation and/or for protecting an animal from endo and/or ecto parasite infestation using N-phenyl-1,1,1-trifluoromethanesulfonamide compounds are provided, together with methods of making the same compounds, and methods of using the same compounds to treat parasite infestations in vivo or ex vivo. N-phenyl-1,1,1-trifluoromethanesulfonamides are also provided.

  提供了一种使用N-苯基-1,1,1-三氟甲烷磺酰胺类化合物治疗动物内外寄生虫感染并/或保护动物免受内外寄生虫感染的方法，以及制备这些化合物的方法，以及使用这些化合物在体内或体外治疗寄生虫感染的方法。同时还提供了N-苯基-1,1,1-三氟甲烷磺酰胺类化合物。
• Metal-Free Iodine-Catalyzed Direct Arylthiation of Substituted Anilines with Thiols
  作者：Daoshan Yang、Kelu Yan、Wei Wei、Jing Zhao、Mengqi Zhang、Xuguang Sheng、Guoqing Li、Shenglei Lu、Hua Wang

  DOI：10.1021/acs.joc.5b00540

  日期：2015.6.19

  Iodine-catalyzed direct arylthiation of substituted anilines for the synthesis of various diaryl sulfides has been developed under metal- and solvent-free conditions. The present method uses readily available thiols as the arylthiation reagents, and environmentally friendly and inexpensive I-2 as the catalyst. Importantly, no base or ligand was necessary. Such a simple, efficient, and economical transformation provides an attractive approach to various diaryl sulfides in good to excellent yields.
• A new class of inhibitors of secretory phospholipase A2: enolized 1,3-dioxane-4,6-dione-5-carboxamides
  作者：W Breitenstein、F Märki、S Roggo、I Wiesenberg、J Pfeilschifter、P Furet、E Beriger

  DOI：10.1016/0223-5234(94)90026-4

  日期：1994.1

  Enolized 1,3-dioxane-4,6-dione-5-carboxamides a were identified as a new class of inhibitors of secretory phospholipase A(2) from human polymorphonuclear leucocytes (h-PMN PLA(2)). Among the more than 30 compounds synthesized, the most potent inhibitors (IC50 0.6-10 mu M) were found in the series of 2,4-disubstituted phenyl analogues of a. Compound 1a was selected for evaluation of its biological profile. This substance potently inhibited secretory PLA(2)s from several sources other than human PMNs, with a clear preference for group II over group I PLA(2), whereas human cytosolic PLA(2) and phospholipase C were not significantly affected. Inhibition of h-PMN PLA(2) was calcium-dependent. In intact mammalian cells stimulated in vitro, the release of arachidonic acid and the generation of prostaglandins and leukotrienes were inhibited at concentrations compatible with inhibition of PLA(2) as an underlying mechanism. In animal models in vivo (carragheenan oedema, adjuvant arthritis, pertussis pleurisy) 1a showed antiinflammatory activity, although the effect was rather weak compared with standard reference compounds.
• CONTROL OF PARASITES IN ANIMALS BY N-[(PHENYLOXY)PHENYL]-1,1,1-TRIFLUOROMETHANESULFONAMIDE AND N-[(PHENYLSULFANYL)PHENYL]-1,1,1-TRIFLUOROMETHANESULFONAMIDE DERIVATIVES
  申请人：Schering-Plough Ltd.

  公开号：EP1890547A2

  公开（公告）日：2008-02-27
• [EN] CONTROL OF PARASITES IN ANIMALS BY N-[(PHENYLOXY)PHENYL]-1,1,1-TRIFLUOROMETHANESULFONAMIDE AND N-[(PHENYLSULFANYL)PHENYL]-1,1,1-TRIFLUOROMETHANESULFONAMIDE DERIVATIVES<br/>[FR] CONTROLE DE PARASITES CHEZ DES ANIMAUX A L'AIDE DE DERIVES DE N-[(PHENYLOXY)PHENYL]-1,1,1-TRIFLUOROMETHANESULFONAMIDE ET DE N-[(PHENYLSULFANYL)PHENYL]-1,1,1-TRIFLUOROMETHANESULFONAMIDE
  申请人：SCHERING PLOUGH LTD

  公开号：WO2006135648A2

  公开（公告）日：2006-12-21

  [EN] Methods for treating an animal for endo and/or ecto parasite infestation and/or for protecting an animal from endo and/or ecto parasite infestation using N-phenyl-1,1,1-trifluoromethanesulfonamide compounds are provided, together with methods of making the same compounds, and methods of using the same compounds to treat parasite infestations in vivo or ex vivo. N-phenyl-1,1,1-trifluoromethanesulfonamides are also provided.
  [FR] L'invention concerne des méthodes pour traiter un animal pour une infestation endoparasitaire et/ou ectoparasitaire et/ou pour protéger un animal contre une infestation endoparasitaire et/ou ectoparasitaire, à l'aide de composés de N-phényl-1,1,1-trifluorométhanesulfonamide. L'invention concerne également des méthodes de fabrication de ces composés et des méthodes d'utilisation de ces composés pour traiter des infestations parasitaires in vivo ou ex vivo. Des N-phényl-1,1,1-trifluorométhanesulfonamides sont également décrits.