Poly(oxy-1,2-ethanediyl), I+/--[2-[[(dodecylthio)thioxomethyl]thio]-2-methyl-1-oxopropyl]-I-methoxy- | 710945-87-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Poly(oxy-1,2-ethanediyl), I+/--[2-[[(dodecylthio)thioxomethyl]thio]-2-methyl-1-oxopropyl]-I-methoxy-
• 英文别名: 2-methoxyethyl 2-dodecylsulfanylcarbothioylsulfanyl-2-methylpropanoate
• CAS: 710945-87-2
• 化学式: C₂₀H₃₈O₃S₃
• 分子量: 422.7
• InChiKey: POWFGZORDMVQGO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.1
• 重原子数：
  26
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  118
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Polymeric prodrugs and subcutaneous and/or intramuscular administration thereof
  申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

  公开号：US20200353090A1

  公开（公告）日：2020-11-12

  The invention relates to new prodrugs of active molecules. These prodrugs allow, in particular, the subcutaneous or intramuscular administration of active molecules of which the subcutaneous or intramuscular administration is problematic or impossible, in particular because of the toxicity at the injection site. The prodrugs according to the invention comprise an active ingredient, covalently linked with a polymer chain, preferably a hydrophilic and/or thermosensitive polymer chain. The invention relates, in particular, to polymeric prodrugs comprising a polymer chain formed at least in part by acrylamide monomer or one of its derivatives, the polymer comprising a proximal part and a terminal part; a first pharmaceutically active molecule covalently coupled to the proximal part of the polymer; possibly a second pharmaceutically active molecule covalently coupled to the terminal part of the polymer.

  该发明涉及新型活性分子的前药。这些前药允许特别是将活性分子皮下或肌肉内注射，而这些活性分子的皮下或肌肉内注射由于在注射部位的毒性而具有问题或不可能，特别是由于在注射部位的毒性。根据本发明的前药包括一种活性成分，与一根聚合物链共价连接，优选为一种亲水性和/或热敏感性聚合物链。该发明特别涉及包括由丙烯酰胺单体或其衍生物之一至少部分形成的聚合物链的聚合物前药，该聚合物包括一个近端部分和一个末端部分；第一种药用活性分子共价结合到聚合物的近端部分；可能第二种药用活性分子共价结合到聚合物的末端部分。
• Cross-linked impact modified polyphosphazenes
  申请人：INTERNATIONAL BUSINESS MACHINES CORPORATION

  公开号：US11059960B2

  公开（公告）日：2021-07-13

  A flame retardant composition and a method of making a flame retardant composition is provided. In an embodiment, the method includes reacting a phosphazene material with an acrylamide monomer material to form a functionalized phosphazene material; initiating a polymerization reaction on a reaction mixture comprising a functionalized phosphazene material and one or more monomers to form a first impact-modified phosphazene material; and reacting the first impact-modified phosphazene material with a poly(dichlorophosphazene) monomer material, and a reactant selected from the group consisting of R1OH, HNR2R3, or a combination thereof, to form a second impact-modified phosphazene material.

  本发明提供了一种阻燃组合物和一种阻燃组合物的制造方法。在一个实施方案中，该方法包括将磷化烯材料与丙烯酰胺单体材料反应，形成官能化磷化烯材料；在包含官能化磷化烯材料和一种或多种单体的反应混合物上引发聚合反应，形成第一抗冲改性磷化烯材料；将第一抗冲改性磷苯材料与聚（二氯磷苯）单体材料和选自 R1OH、HNR2R3 或其组合的反应物反应，形成第二抗冲改性磷苯材料。
• THIOCARBONYLTHIO-FREE RAFT POLYMERS AND THE PROCESS OF MAKING THE SAME
  申请人：Henkel IP & Holding GmbH

  公开号：EP3334766A1

  公开（公告）日：2018-06-20
• PRODROGUES POLYMÈRES ET LEUR ADMINISTRATION SOUS-CUTANEE ET/OU INTRAMUSCULAIRE
  申请人：Centre National de la Recherche Scientifique

  公开号：EP3710061A1

  公开（公告）日：2020-09-23
• AMPHIPHILIC BLOCK COPOLYMER AND METHOD FOR PREPARING SAME
  申请人：Charleux Bernadette

  公开号：US20110207881A1

  公开（公告）日：2011-08-25

  The invention relates to an amphiphilic block copolymer, to the preparation thereof, and to the use thereof in the form of a self-stabilizing latex. The copolymer has the formula R 5 O—[—CH 2 CH 2 —O—] n —C(═O)—CR 3 R 4 —[CH 2 CR 6 R 7 ] m —S—C(═S)—S—R 1 where: R 1 is a straight or branched alkyl group, an alkenyl group having one or more —C═C— bonds, or an alkynyl group having one or more —C≡C— bonds, said groups including 8 to 18 carbon atoms; 20≦n≦100; R 3 and R 4 each are independently H, an alkyl group with 1 to 4 carbon atoms, or a nitrile group, at least one of R 3 and R 4 being different than H; R 6 is a phenyl group or an alkoxycarbonyl group in which the alkoxy group includes 1 to 8 carbon atoms; R 7 is a hydrogen atom or a methyl radical; and 20≦m≦1000. The preparation method comprises: preparing an aqueous solution of a compound R 1 —S—C(═S)—S—CR 3 R 4 —C(═O)—OR 2 in which R 2 is R 5 —[—O—CH 2 CH 2 —] n —, R 5 being a hydrophilic group and 20≦n≦100; adding to said solution one or more hydrophobic monomers of the formula (II) R 6 —CR 7 ═CH 2 and a free radical polymerisation initiator; and heating said aqueous solution to a temperature of 60-90° C.