Monocarnitin-citrat | 25016-75-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Monocarnitin-citrat
• 英文别名: 2-Hydroxypropane-1,2,3-tricarboxylic acid;3-hydroxy-4-(trimethylazaniumyl)butanoate
• CAS: 25016-75-5
• 化学式: C₆H₈O₇*C₇H₁₅NO₃
• 分子量: 353.326
• InChiKey: DEVLFMFUNRCKGE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.05
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  193
• 氢给体数：
  5
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  柠檬酸 、 CARNITINE 生成 Monocarnitin-citrat
  参考文献：
  名称：

  具有可逆超分子粘附力的生物相容性坚韧离子凝胶

  摘要：

  尽管已经广泛研究了各种方法，但很难平衡内聚能和界面粘合能以获得具有高机械强度和高粘合强度的可逆粘合剂。在此，开发了一种生物相容性柠檬酸/ L -(−)-肉碱（CAC）基离子液体作为溶剂，以制备用于可逆工程粘合剂和生物粘合剂的坚韧且高粘合强度的离子凝胶。制备的离子凝胶表现出良好的机械性能，包括拉伸强度（14.4 MPa）、杨氏模量（48.1 MPa）、韧性（115.2 MJ m –3 ）和对玻璃基板的高粘附强度（24.4 MPa）。此外，离子凝胶可以在湿生物组织的界面上形成机械匹配的坚韧粘附（界面韧性约为191 J m –2 ），并且可以根据需要通过盐溶液剥离，从而扩展了在伤口粘连和伤口粘连等各种临床场景中的潜在应用。器官的无损转移。

  DOI：

  10.1021/jacs.4c01758

文献信息

• COMPOSITION CONTAINING ORGANIC AMMONIUM SALT
  申请人：Miyoshi Oil & Fat Co., Ltd.

  公开号：EP3925672A1

  公开（公告）日：2021-12-22

  Provided is a novel composition with excellent stability which contains an organic ammonium salt. The composition containing an organic ammonium salt of the present invention contains an organic ammonium salt having a hydrogen-bonding functional group(s) in a cation and/or an anion, and a surfactant.

  本发明提供了一种稳定性极佳的新型组合物，其中含有一种有机铵盐。 本发明中含有有机铵盐的组合物包含一种在阳离子和/或阴离子中具有氢键官能团的有机铵盐和一种表面活性剂。
• Detection method for quaternary ammonium compound having γ-carboxyl group
  申请人：Kaohsiung Medical University

  公开号：US10703969B2

  公开（公告）日：2020-07-07

  A detection method for a quaternary ammonium compound having a γ-carboxyl group includes: mixing a sample including the quaternary ammonium compound having the γ-carboxyl group, a fluorescent compound having a fluorophore and a polar aprotic solvent to form a reaction solution. A SN2 nucleophilic substitution reaction is performed between the fluorophore of the fluorescent compound and the γ-carboxyl group of the quaternary ammonium compound to obtain a derivation solution including a derivative which is a quaternary ammonium compound with the γ-carboxyl group substituted with the fluorophore of the fluorescent compound. An extractant and a cosolvent are added to the derivation solution to form a water-in-oil emulsion which disperses in the derivation solution, followed by extracting the derivative from the derivation solution by the extractant to obtain an analytic solution, wherein a polarity of the extractant is higher than a polarity of the polar aprotic solvent. The derivative in the analytic solution is detected; and therefore, the quaternary ammonium compound having the γ-carboxyl group in the sample can be easily detected by reverse-phase liquid chromatography, fluorescence spectrometry or mass spectrometry.

  一种具有γ-羧基的季铵盐化合物的检测方法包括：将包括具有γ-羧基的季铵盐化合物的样品、具有荧光团的荧光化合物和极性钝化溶剂混合形成反应溶液。在荧光化合物的荧光团和季铵盐化合物的γ-羧基之间进行 SN2 亲核取代反应，以获得衍生物溶液，其中包括一种衍生物，该衍生物是γ-羧基被荧光化合物的荧光团取代的季铵盐化合物。在衍生溶液中加入萃取剂和共溶剂，形成油包水型乳液，分散在衍生溶液中，然后用萃取剂从衍生溶液中萃取衍生物，得到分析溶液，其中萃取剂的极性高于极性钝化溶剂的极性。分析溶液中的衍生物可被检测出来；因此，样品中具有γ-羧基的季铵化合物可以很容易地通过反相液相色谱法、荧光光谱法或质谱法检测出来。
• Detection kit for quaternary ammonium compound having γ-carboxyl group
  申请人：Kaohsiung Medical University

  公开号：US11016096B2

  公开（公告）日：2021-05-25

  The invention discloses a detection kit for a quaternary ammonium compound having a γ-carboxyl group. The kit includes a fluorescent compound having a fluorophore. The fluorophore of the fluorescent compound is used for forming a derivative with the γ-carboxyl group of the quaternary ammonium compound by an SN2 nucleophilic substitution reaction. The kit further includes a polar aprotic solvent used for accelerating the SN2 nucleophilic substitution reaction.

  本发明公开了一种具有γ-羧基的季铵盐化合物的检测试剂盒。该试剂盒包括一种具有荧光团的荧光化合物。荧光化合物的荧光团用于通过 SN2 亲核取代反应与季铵盐化合物的 γ 羧基形成衍生物。试剂盒还包括一种极性钝化溶剂，用于加速 SN2 亲核取代反应。
• ULTRAFINE L-CARNITINE, METHODS OF PREPARING THE SAME, COMPOSITIONS CONTAINING THE SAME, AND METHODS OF USING THE SAME
  申请人：Sigma-Tau Healthscience S.p.A.

  公开号：EP1218001A1

  公开（公告）日：2002-07-03
• EP1218001A4
  申请人：——

  公开号：EP1218001A4

  公开（公告）日：2005-05-18