(4,5-O-Isopropyliden)-2-carbethoxy-4,5-dihydroxy-pent-2-en-saeure-ethylester | 39029-56-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (4,5-O-Isopropyliden)-2-carbethoxy-4,5-dihydroxy-pent-2-en-saeure-ethylester
• 英文别名: Diethyl 2-[(2,2-dimethyl-1,3-dioxolan-4-yl)methylidene]propanedioate
• CAS: 39029-56-6
• 化学式: C₁₃H₂₀O₆
• 分子量: 272.298
• InChiKey: SAJUEZQKCAQUJF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• [EN] PROCESS FOR THE PREPARATION OF GLYCERALDEHYDE ACETONIDE<br/>[FR] PROCEDE DE PREPARATION DE GLYCERALDEHYDE ACETONIDE
  申请人：DSM IP ASSETS BV

  公开号：WO2005040149A1

  公开（公告）日：2005-05-06

  The invention relates to a process for the preparation of glyceraldehyde acetonide by oxidation of 2,2-dimethyl-1,3-dioxolane-4-methanol by an oxidizing agent, wherein the 2,2-dimethyl-1,3-dioxolane-4-methanol is oxidized by an organic N-chloro compound in the presence of an inert base and TEMPO or a TEMPO-derivative. In one embodiment of the invention enantiomerically enriched glyceraldehyde acetonide is prepared from the corresponding enantiomerically enriched 2,2-dimethyl-1,3-dioxolane-4-methanol. Preferably, the organic N-chloro compount is trichloroisocyanuric acid or dichlorodimethyl hydantoin. Preferably, the inert base is sodium acetate or sodium bicarbonate.

  该发明涉及一种通过氧化2,2-二甲基-1,3-二氧环戊烷-4-甲醇制备甘油醛缩丙醚的方法，其中2,2-二甲基-1,3-二氧环戊烷-4-甲醇被有机N-氯化合物在惰性碱和TEMPO或TEMPO衍生物存在下氧化。在该发明的一个实施例中，对映异构富集的甘油醛缩丙醚是从相应对映异构富集的2,2-二甲基-1,3-二氧环戊烷-4-甲醇制备的。最好使用的有机N-氯化合物是三氯异氰尿酸或二氯二甲基咪唑啉酮。最好使用的惰性碱是醋酸钠或碳酸氢钠。
• [EN] PROCESS FOR THE PREPARATION OF (S)-GLYCERALDEHYDE ACETONIDE<br/>[FR] PROCEDE POUR PREPARER DU (S)-GLYCERALDEHYDE ACETONIDE
  申请人：DSM IP ASSETS BV

  公开号：WO2005037819A1

  公开（公告）日：2005-04-28

  The invention relates to a process for the preparation of (S)-glyceraldehyde acetonide in aqueous solution from 3,4-O-­isopropylidene-L-threonic acid or a salt thereof in aqueous solution, and hypochlorite in aqueous solution wherein the aqueous hypochlorite solution has a pH > 7.5 and wherein during addition of at least 0.1 molar equivalents of hypochlorite based on the amount of 3,4-O-isopropylidene-­L-threonic acid, an acid solution is not simultaneously added. The invention also relates to a process according to the invention, wherein 3,4-O-isopropylidene-L-threonic acid or a salt thereof is prepared from 5,6-O-isopropylidene-L-ascorbic acid or a salt thereof in the presence of H2O2 and a base in a manner known per se, wherein excess H2O2 is optionally removed by catalase. The invention also relates to a process according to the invention, wherein 5,6-O-isopropylidene-L-ascorbic acid or a salt thereof is prepared by reacting L-ascorbic acid or a salt thereof with an acetonide forming agent, preferably in the presence of an acid catalyst.

  本发明涉及一种从3,4-O-异丙基苹果酸或其盐在水溶液中和水溶液中次氯酸盐制备(S)-甘油醛缩醛的方法，其中水溶液中的次氯酸盐的pH>7.5，且在添加至少0.1摩尔当量的次氯酸盐（基于3,4-O-异丙基苹果酸的量）期间，不同时添加酸性溶液。本发明还涉及一种根据本发明的方法，其中3,4-O-异丙基苹果酸或其盐是在已知的情况下在H2O2和碱的存在下制备的，其中过量的 可以通过过氧化氢酶去除。本发明还涉及一种根据本发明的方法，其中5,6-O-异丙基-L-抗坏血酸酸或其盐是通过将L-抗坏血酸或其盐与缩醛形成剂反应制备的，优选在酸性催化剂的存在下。
• PROCESS FOR THE PREPARATION OF GLYCERALDEHYDE ACETONIDE
  申请人：DSM IP Assets B.V.

  公开号：EP1678158A1

  公开（公告）日：2006-07-12
• PROCESS FOR THE PREPARATION OF (S)-GLYCERALDEHYDE ACETONIDE
  申请人：DSM IP Assets B.V.

  公开号：EP1673364A1

  公开（公告）日：2006-06-28
• Process for the preparation of (s)-glyceraldehyde acetonide
  申请人：Quaedflieg Leonard Mario Peter Jan

  公开号：US20070073068A1

  公开（公告）日：2007-03-29

  The invention relates to a process for the preparation of (S)-glyceraldehyde acetonide in aqueous solution from 3,4-O-isopropylidene-L-threonic acid or a salt thereof in aqueous solution, and hypochlorite in aqueous solution wherein the aqueous hypochlorite solution has a pH >7.5 and wherein during addition of at least 0.1 molar equivalents of hypochlorite based on the amount of 3,4-O-isopropylidene-L-threonic acid, an acid solution is not simultaneously added. The invention also relates to a process according to the invention, wherein 3,4-O-isopropylidene-L-threonic acid or a salt thereof is prepared from 5,6-O-isopropylidene-L-ascorbic acid or a salt thereof in the presence of H 2 O 2 and a base in a manner known per se, wherein excess H 2 O 2 is optionally removed by catalase. The invention also relates to a process according to the invention, wherein 5,6-O-isopropylidene-L-ascorbic acid or a salt thereof is prepared by reacting L-ascorbic acid or a salt thereof with an acetonide forming agent, preferably in the presence of an acid catalyst.