3-(2-Fluoro-4-methoxyphenyl)-7-methoxy-2-methyl-3,4-dihydronaphthalen-1-yl trifluoromethanesulfonate | 1245636-82-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-(2-Fluoro-4-methoxyphenyl)-7-methoxy-2-methyl-3,4-dihydronaphthalen-1-yl trifluoromethanesulfonate
• 英文别名: [3-(2-Fluoro-4-methoxyphenyl)-7-methoxy-2-methyl-3,4-dihydronaphthalen-1-yl] trifluoromethanesulfonate
• CAS: 1245636-82-1
• 化学式: C₂₀H₁₈F₄O₅S
• 分子量: 446.42
• InChiKey: WGPHJNUWPFLYJJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  70.2
• 氢给体数：
  0
• 氢受体数：
  9

文献信息

• TETRAHYDRONAPHTHALEN-2-OL DERIVATIVES
  申请人：Stock Herman Thijs

  公开号：US20100240748A1

  公开（公告）日：2010-09-23

  The present invention relates to novel tetrahydronaphthalen-2-ol derivatives, to pharmaceutical compositions comprising these compounds and to their use in therapy, in particular to their use for the manufacture of a medicament for the prevention or treatment of lower urinary tract symptoms, benign prostate hyperplasia, prostate cancer, hot flushes, anxiety, depression, breast cancer, medullary thyroid carcinoma, ovarian cancer, inflammatory bowel disease, arthritis, endometriosis, and colon cancer.

  本发明涉及新型四氢萘-2-醇衍生物，包括这些化合物的药物组合物以及它们在治疗中的应用，特别是它们用于制造预防或治疗下尿道症状、良性前列腺增生、前列腺癌、潮热、焦虑、抑郁、乳腺癌、髓样甲状腺癌、卵巢癌、炎症性肠病、关节炎、子宫内膜异位症和结肠癌的药物的用途。
• [EN] TETRAHYDRONAPHTHALEN-2-OL DERIVATIVES<br/>[FR] DÉRIVÉS DU TÉTRAHYDRONAPHTALÈN-2-OL
  申请人：ORGANON NV

  公开号：WO2010103095A1

  公开（公告）日：2010-09-16

  The present invention relates to novel tetrahydronaphthalen-2-ol derivatives, to pharmaceutical compositions comprising these compounds and to their use in therapy, in particular to their use for the manufacture of a medicament for the prevention or treatment of lower urinary tract symptoms,benign prostate hyperplasia,prostate cancer,hot flushes, anxiety, depression, breast cancer, medullary thyroid carcinoma, ovarian cancer, inflammatory bowel disease, arthritis, endometriosis, and colon cancer.

  本发明涉及新型四氢萘-2-醇衍生物，包括这些化合物的药物组合物，以及它们在治疗中的应用，特别是用于制造用于预防或治疗下尿路症状、良性前列腺增生、前列腺癌、潮热、焦虑、抑郁、乳腺癌、髓样甲状腺癌、卵巢癌、炎症性肠病、关节炎、子宫内膜异位症和结肠癌的药物。
• US8063102B2
  申请人：——

  公开号：US8063102B2

  公开（公告）日：2011-11-22