propyl 5-bromopentanoate | 13931-37-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: propyl 5-bromopentanoate
• 英文别名: 5-Brom-valeriansaeure-propylester
• CAS: 13931-37-8
• 化学式: C₈H₁₅BrO₂
• 分子量: 223.11
• InChiKey: GKTWIJVDNVTXCV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  11
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  propyl 5-bromopentanoate 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 生成 propyl 5-[2-(difluoromethoxy)-5-formylphenoxy]pentanoate
  参考文献：
  名称：

  NOVEL SOFT PDE4 INHIBITORS

  摘要：

  本发明涉及新的磷酸二酯酶抑制剂，更具体地是软性PDE4抑制剂，包括这种抑制剂的组合物，特别是制药用途的组合物，并且涉及使用这种抑制剂来治疗和预防疾病的用途。特别地，本发明涉及新的软性PDE4抑制剂组合物，特别是制药用途的组合物，并且涉及使用这种抑制剂来治疗和预防疾病的用途。此外，本发明还涉及治疗方法和使用所述化合物制造药物，用于多种治疗适应症，包括炎症性疾病。

  公开号：

  US20140187555A1
• 作为产物：
  描述：

  丙醇 、 5-溴戊酸 在 硫酸 作用下， 生成 propyl 5-bromopentanoate
  参考文献：
  名称：

  Cerny,A. et al., Collection of Czechoslovak Chemical Communications, 1967, vol. 32, # 3, p. 1035 - 1044

  摘要：

  DOI：

文献信息

• Structure–activity relationships for ketamine esters as short-acting anaesthetics
  作者：Jiney Jose、Swarna A. Gamage、Martyn G. Harvey、Logan J. Voss、James W. Sleigh、William A. Denny

  DOI：10.1016/j.bmc.2013.06.047

  日期：2013.9

  aliphatic esters of the non-opioid anaesthetic/analgesic ketamine were prepared and their properties as shorter-acting analogues of ketamine itself were explored in an infused rat model, measuring the time after infusion to recover from both the anaesthetic (righting reflex) and analgesic (response to stimulus) effects. The potency of the esters as sedatives was not significantly related to chain length

  制备了一系列非阿片类麻醉剂/镇痛剂氯胺酮的脂族酯，并在输注的大鼠模型中探索了其作为氯胺酮本身的短效类似物的性质，测量了输注后从两种麻醉剂中恢复的时间（对位反射）和镇痛作用（对刺激的反应）。酯类作为镇静剂的效力与链长没有显着关系，但是Me，Et和i-Pr酯的剂量效价更高（最多比氯胺酮低两倍），而n-Pr酯的效价更低（从2-比氯胺酮少6倍）。对于Me，Et和i-Pr酯，麻醉后的回收率比氯胺酮本身快10–15倍；对于n-Pr酯，麻醉剂的回收率比氯胺酮快20–25倍。
• [EN] NOVEL SOFT PDE4 INHIBITORS<br/>[FR] NOUVEAUX INHIBITEURS DOUX DE PDE4
  申请人：AMAKEM NV

  公开号：WO2013021021A1

  公开（公告）日：2013-02-14

  The present invention relates to new phosphodiesterase inhibitors, more specifically soft PDE4 inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In particular, the present invention relates to new soft PDE4 inhibitors compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In addition, the invention relates to methods of treatment and use of said compounds in the manufacture of a medicament for the application to a number of therapeutic indications including inflammatory diseases.

  本发明涉及新的磷酸二酯酶抑制剂，更具体地说是软PDE4抑制剂，包括这些抑制剂的组合物，特别是制药品，以及这些抑制剂在疾病的治疗和预防中的用途。具体来说，本发明涉及新的软PDE4抑制剂组合物，特别是包括这些抑制剂的制药品，以及这些抑制剂在疾病的治疗和预防中的用途。此外，本发明涉及治疗方法和使用上述化合物制造药物的方法，适用于多种治疗适应症，包括炎症性疾病。
• Polyhydroxyalkanoate having vinyl group, ester group, carboxyl group, and sulfonic group, and method of producing the same
  申请人：Kenmoku Takashi

  公开号：US20070073006A1

  公开（公告）日：2007-03-29

  To provide a novel polyhydroxyalkanoate having a reactive functional group in a molecule and a method of producing the same; and a novel polyhydroxyalkanoate having a new function obtained by chemically modifying the polyhydroxyalkanoate having a reactive functional group and a method of producing the same. By utilizing a vinyl group of a polyhydroxyalkanoate containing a unit having the vinyl group at a side chain thereof, a polyhydroxyalkanoate containing units having a carboxyl group, an amide group, and a sulfonic group in a molecule is induced.

  提供一种分子中具有反应性功能基团的新型聚羟基脂肪酸酯及其制备方法；以及通过化学修饰具有反应性功能基团的聚羟基脂肪酸酯获得的具有新功能的新型聚羟基脂肪酸酯及其制备方法。通过利用聚羟基脂肪酸酯中含有侧链上乙烯基的单元的乙烯基，诱导聚羟基脂肪酸酯中含有羧基、酰胺基和磺酸基的单元。
• Polyhydroxyalkanoic Acid Having Vinyl, Ester, Carboxyl or Sulfonic Acid Group and Producing Method Therefor
  申请人：Kenmoku Takashi

  公开号：US20080064828A1

  公开（公告）日：2008-03-13

  The invention is to provide a novel polyhydroxyalkanoate having a reactive function group within the molecule and a producing method therefor In a polyhydroxyalkanoate containing a unit having a vinyl group in a side chain, such vinyl group is utilized for deriving a polyhydroxyalkanoate comprising a carboxyl group or a unit having an amide group and a sulfonic acid group.

  本发明旨在提供一种新型聚羟基烷酸酯，其分子内具有反应性功能团，并提供其制备方法。在含有侧链中具有乙烯基团的聚羟基烷酸酯中，利用该乙烯基团来获得含有羧基或含有酰胺基和磺酸基的聚羟基烷酸酯。
• Ketamine Derivatives
  申请人：SLEIGH James Wallace

  公开号：US20150259277A1

  公开（公告）日：2015-09-17

  The present invention relates to ketamine derivatives of the formula (I), pharmaceutical compositions comprising them, and methods for treating pain comprising administering them, and their use in the manufacture of medicaments for treating pain. The present invention also relates to methods for anaesthetizing and methods for sedating a subject comprising administering ketamine derivatives of the formula (II).

  本发明涉及公式（I）的氯胺酮衍生物，包括它们的药物组成物，以及用于治疗疼痛的给药方法，以及它们用于制造治疗疼痛药物的用途。本发明还涉及给予公式（II）的氯胺酮衍生物的方法，用于麻醉和镇静受试者的方法。