N,N-diethyl-DL-alanine o-toluidide | 42459-44-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N-diethyl-DL-alanine o-toluidide
• 英文别名: N,N-Diaethyl-DL-alanin-o-toluidid；2-(diethylamino)-N-(2-methylphenyl)propanamide
• CAS: 42459-44-9
• 化学式: C₁₄H₂₂N₂O
• 分子量: 234.341
• InChiKey: WHAUEGOOIFHALY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Method and apparatus for the production of ionic cloths for use in ionic dressings
  申请人：RICOH KYOSAN INC.

  公开号：EP0395476A2

  公开（公告）日：1990-10-31

  Novel wound dressings and methods and systems for preparing them are provided herein. The wound dres­sing includes a substrate at least part of which is cellulosic and which has been chemically modified to have ionic-adsorbing sulfate sites thereon. A ca­tionic form of a physiologically- or biologically-­active agent is adsorbed therein. Upon contact with body exudate from wounds to which such wound dress­ing is applied, the physiologically- or biologi­cally-active agent is released in a controlled man­ner by ion exchange with the ions in the exudate, in proportion to the amount of the exudate. This is due to the fact that the adsorption is by means of an ionic bond. The strength of such ionic bond is such that the controlled release is achieved. This controlled release thus reduces unnecessary exposure of unwounded skin surface to the physiologically-or biologically-active agent. Commercially-viable me­thods and systems are also provided for producing substrates for the production of such wound dress­ings. The method includes the steps of soaking the substrate by passing the substrate through a bath of an appropriate chemical reactant solution, and squeezing the excess solution from the soaked sub­strate to provide a wetted substrate. In the im­proved method, the following additional steps are carried out, namely, the wetted substrate is sup­ported on a suitable backing member which sub­stantially inhibits the escape of such solution from the environment of the wetted substrate, preferably by first cutting the wetted substrate to a selected length. The so-supported substrate is cured in a heating means to provide the derivatized substrate. The so-cured derivatized substrate is washed. Fi­nally, the washed derivatized substrate is suitably dried.

  本文提供了新型伤口敷料及其制备方法和系统。伤口敷料包括一种基质，其中至少有一部分是纤维素，并经过化学改性，使其具有离子吸附硫酸盐位点。其中吸附有生理或生物活性剂的阳离子形式。在与伤口渗出物接触时，生理活性剂或生物活性剂会通过与渗出物中的离子进行离子交换，以可控的方式释放出来，释放量与渗出物的量成比例。这是因为吸附是通过离子键进行的。这种离子键的强度可以实现控制释放。因此，这种控制释放可减少未受伤皮肤表面不必要地接触生理或生物活性剂。还提供了商业上可行的方法和系统，用于生产这种伤口敷料的基材。该方法包括以下步骤：通过适当的化学反应剂溶液槽浸泡基质，并从浸泡的基质中挤出多余的溶液，以提供润湿的基质。在改进的方法中，还进行了以下步骤，即把浸湿的基片支撑在适当的支撑件上，该支撑件基本上能抑制溶液从浸湿基片的环境中逸出，最好是先把浸湿的基片切割成选定的长度。如此支撑的基底在加热装置中固化，以提供衍生化基底。将固化后的衍生基底进行洗涤。最后，将洗净的衍生化基底适当干燥。
• 2-Alkyl-3-benzoylbenzofurans and pharmaceutical compositions containing them
  申请人：Taro Pharmaceutical Industries Ltd.

  公开号：EP0338746B1

  公开（公告）日：1994-08-31
• COMPOSITIONS OPHTALMOLOGIQUES ET LEUR UTILISATION
  申请人：Laboratoires THEA

  公开号：EP1858481B1

  公开（公告）日：2019-05-08
• COMPOSITIONS OPHTALMOLOGIQUES ET LEUR MODE D'UTILISATION
  申请人：Laboratoires THEA

  公开号：EP1858481A1

  公开（公告）日：2007-11-28
• Electrostatically self-assembled antimicrobial coating for medical applications
  申请人：Akhave R. Jay

  公开号：US20050152955A1

  公开（公告）日：2005-07-14

  A electrostatically self-assembled coating having a biologically active agent incorporated therein is provided. More particularly, a wound dressing having an antimicrobial coating within the dressing construction wherein an antimicrobial agent is released from the dressing over a period of time is produced using a layer-by-layer deposition process.