8-Methyl-1-oxaspiro<4.5>decane | 55047-03-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧唑烯
• 英文名称: 8-Methyl-1-oxaspiro<4.5>decane
• 英文别名: 8-methyl-1-oxaspiro(4.5)decane；8-Methyl-1-oxaspiro[4.5]decane
• CAS: 55047-03-5
• 化学式: C₁₀H₁₈O
• 分子量: 154.252
• InChiKey: BYELZVKKZUWIPJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-methyl-1-(2-propenyl)-3-cyclohexen-1-ol 在 sodium hydroxide 、 硼烷 、 双氧水 、 potassium carbonate 、 对甲苯磺酰氯 作用下， 以 吡啶 为溶剂， 反应 28.0h， 生成 8-Methyl-1-oxaspiro<4.5>decane
  参考文献：
  名称：

  Terpenes and terpene derivatives - XV. [1 ] Synthesis of 4,8-dimethyl-2-(2-methyl-1-propenyl)--1-oxaspiro(4.5]dec-7-ene (“bisabolene oxide”)

  摘要：

  DOI：

  10.1016/s0040-4020(01)91487-5

文献信息

• TYK2 INHIBITORS AND USES THEREOF
  申请人：Nimbus Lakshmi, Inc.

  公开号：US20200231594A1

  公开（公告）日：2020-07-23

  The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

  本发明提供了化合物、其组合物以及使用这些化合物来抑制TYK2和治疗TYK2介导的疾病的方法。
• TYK2 inhibitors and uses thereof
  申请人：Nimbus Lakshmi, Inc.

  公开号：US10562907B2

  公开（公告）日：2020-02-18

  The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

  本发明提供了用于抑制 TYK2 和治疗 TYK2 介导的疾病的化合物、其组合物和使用方法。
• High performing, high impact bloom accord
  申请人：International Flavors & Fragrances Inc.

  公开号：US10975327B2

  公开（公告）日：2021-04-13

  Disclosed are fragrance accords each containing (i) at least 7 wt % of one or more Class 1 fragrance ingredients, (ii) 5 to 85 wt % of one or more Class 2 fragrance ingredients, and (iii) 0 to 80 wt % of one or more Class 3 fragrance ingredients. The Classes 1, 2, and 3 fragrance ingredients are defined by experimental velocity. Also disclosed are delivery systems and consumer products containing such a fragrance accord.

  所公开的香味调和物分别含有 (i) 至少 7 wt % 的一种或多种 1 级香味成分，(ii) 5 至 85 wt % 的一种或多种 2 级香味成分，以及 (iii) 0 至 80 wt % 的一种或多种 3 级香味成分。第 1、2 和 3 类香料成分由实验速度定义。此外，还公开了含有这种香味调和物的输送系统和消费品。
• General synthesis of 1-oxaspiro[4.5]decan-2-ones and 1-oxaspiro[4.5]decanes from 5-methylene-2(5H)-furanone
  作者：Daniel Alonso、Josep Font、Rosa M. Ortuno

  DOI：10.1021/jo00019a019

  日期：1991.9

  5-Methylene-2(5H)-furanone underwent Diels-Alder cycloadditions to butadiene and several acyclic and cyclic C-substituted dienes, respectively, affording bicyclic and tricyclic spiroadducts in good yields. These compounds are precursors of other unsaturated and saturated spirolactones and also spiroethers, which were obtained through simple chemical reactions, i.e., hydrogenation of C-C double bonds, reduction of the carbonyl group, and Michael addition. The synthesis of 32 spirolactones and eight spiroethers illustrates the scope and efficiency of this method. Many of these products are suitable for use as components of perfumes and aromas owing to their olfactive properties.
• PHARMACEUTICALLY ACTIVE PYRAZOLO-TRIAZINE DERIVATIVES
  申请人：LEAD DISCOVERY CENTER GMBH

  公开号：US20150111873A1

  公开（公告）日：2015-04-23

  Pyrazolo[1,5-a][1,3,5]triazine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, immunological diseases, autoimmune diseases, cardiovascular diseases, cell proliferative diseases, inflammation, erectile dysfunction and stroke, and pharmaceutical compositions containing at least one of said pyrazolo[1,5-a][1,3,5]triazine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said pyrazolo[1,5-a][1,3,5]triazine derivatives as inhibitors for a protein kinase.