8-methyl-1-oxaspiro(4.5)-dec-7-ene | 94607-85-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧唑烯
• 英文名称: 8-methyl-1-oxaspiro(4.5)-dec-7-ene
• 英文别名: 8-Methyl-1-oxaspiro[4.5]dec-7-ene
• CAS: 94607-85-9
• 化学式: C₁₀H₁₆O
• 分子量: 152.236
• InChiKey: GWFOOEBELARBGT-UHFFFAOYSA-N

物化性质

• 沸点：
  224.0±29.0 °C(predicted)
• 密度：
  0.97±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-methyl-1-(2-propenyl)-3-cyclohexen-1-ol 在 sodium hydroxide 、 硼烷 、 双氧水 、 potassium carbonate 、 对甲苯磺酰氯 作用下， 以 吡啶 为溶剂， 反应 28.0h， 生成 8-methyl-1-oxaspiro(4.5)-dec-7-ene
  参考文献：
  名称：

  Terpenes and terpene derivatives - XV. [1 ] Synthesis of 4,8-dimethyl-2-(2-methyl-1-propenyl)--1-oxaspiro(4.5]dec-7-ene (“bisabolene oxide”)

  摘要：

  DOI：

  10.1016/s0040-4020(01)91487-5

文献信息

• 4-HETEROARYL-TETRAHYDROQUINOLINES AND THEIR USE AS INHIBITORS OF THE CHOLESTERIN-ESTER TRANSFER PROTEIN
  申请人：STOLTEFUSS JURGEN

  公开号：US20070142420A1

  公开（公告）日：2007-06-21

  Hetero-tetrahydroquinolines can be prepared either by condensing correspondingly substituted hetero-tetrahydroquinoline aldehydes with the desired substituent or by reducing the corresponding keto-substituted hetero-tetrahydroquinolines, followed by introduction of the desired substituent by customary methods. The hetero-tetrahydroquinolines are suitable for use as active compounds in medicaments, in particular in medicaments for treating artheriosclerosis and dyslipidaemias.
• METHOD OF INHIBITING REMNANT LIPOPROTEIN PRODUCTION
  申请人：Okamoto Hiroshi

  公开号：US20110189210A1

  公开（公告）日：2011-08-04

  The present invention aims at provision of a method for inhibiting remnant lipoprotein production and a remnant lipoprotein production inhibitor, which includes administering a compound having a CETP inhibitory activity to an administration subject. The remnant lipoprotein production inhibitor of the present invention contains a compound having a CETP inhibitory activity as an active ingredient.
• Terpenes and terpene derivatives - XV. [1 ] Synthesis of 4,8-dimethyl-2-(2-methyl-1-propenyl)--1-oxaspiro(4.5]dec-7-ene (“bisabolene oxide”)
  作者：Bernd Buchmann、Helga Marschall-Weyerstahl、Peter Weyerstahl

  DOI：10.1016/s0040-4020(01)91487-5

  日期：1984.1