9-氨基-3-氧杂-7-氮杂双环[3.3.1]壬烷-7-甲酸叔丁酯 | 1251015-74-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 9-氨基-3-氧杂-7-氮杂双环[3.3.1]壬烷-7-甲酸叔丁酯
• 英文名称: tert-Butyl 9-amino-3-oxa-7-azabicyclo[3.3.1]nonane-7-carboxylate
• CAS: 1251015-74-3
• 化学式: C₁₂H₂₂N₂O₃
• 分子量: 242.31
• InChiKey: QYBPHULJRAEWEO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  64.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] NOVEL QUINOLINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE<br/>[FR] NOUVEAUX COMPOSÉS DE QUINOLÉINE POUR LE TRAITEMENT D'UNE MALADIE AUTO-IMMUNE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2021048200A1

  公开（公告）日：2021-03-18

  The present invention relates to compounds of formula (I), (I), wherein R1, R2 and R3 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

  本发明涉及式(I)的化合物，其中R1、R2和R3如本文所述，以及其药用可接受的盐、对映体或非对映异构体，以及包括这些化合物的组合物和使用这些化合物的方法。
• NOVEL PYRAZOLOPYRIDINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE
  申请人：F. Hoffmann-La Roche AG

  公开号：EP3847173A1

  公开（公告）日：2021-07-14
• NOVEL QUINOLINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE
  申请人：F. Hoffmann-La Roche AG

  公开号：EP4028125A1

  公开（公告）日：2022-07-20
• PYRROLIDINYL AMIDE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE
  申请人：Hoffmann-La Roche Inc.

  公开号：US20210323977A1

  公开（公告）日：2021-10-21

  The present invention relates to compounds of formula (I) wherein R 1 , R 2 , R 3 and R 4 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
• PYRAZOLOPYRIDINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE
  申请人：Hoffmann-La Roche Inc.

  公开号：US20210355122A1

  公开（公告）日：2021-11-18

  The present invention relates to compounds of formula (I), wherein R 1 , R 2 , R 3 and R 4 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.