2-((2-(dimethylamino)ethyl)methylamino)ethyl methacrylate | 21567-46-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-((2-(dimethylamino)ethyl)methylamino)ethyl methacrylate
• 英文别名: 2-[2-(Dimethylamino)ethyl-methylamino]ethyl 2-methylprop-2-enoate
• CAS: 21567-46-4
• 化学式: C₁₁H₂₂N₂O₂
• 分子量: 214.308
• InChiKey: HLAWEBZRFVSDJF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  15
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  32.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-{[2-(二甲氨基)乙基]甲基氨基}乙醇 、 甲基丙烯酰氯 在 吡啶 、 三乙胺 作用下， 反应 24.5h， 以20%的产率得到2-((2-(dimethylamino)ethyl)methylamino)ethyl methacrylate
  参考文献：
  名称：

  Micellar Interpolyelectrolyte Complexes with a Compartmentalized Shell

  摘要：

  We investigate the formation of micellar interpolyelectrolyte complexes (IPECs) from multicompartment micelles (MCMs) of polybutadiene-block-poly(1-methyl-2-vinylpyridinium methylsulfate)-block-poly(methacrylic acid) (BVqMAA) triblock terpolymers and polycations of opposite charge. As cationic material, predominantly a polymer with a high charge density is used: quaternized poly(2-((2-(dimethylamino)ethyl)methylamino)ethyl methacrylate) (PDAMAq), which carries two positive net charges per monomer unit. Upon IPEC formation at different charge stoichiometries, particles with a compartmentalized IPEC shell are formed. These rather unusual structures even form when both BVqMAA micelles and PDAMAq are mixed at high salinity, followed by dialysis, indicating that the structures formed are not kinetically trapped. Whereas the nature of the polycation seems to play a minor role, our studies suggest that the length of the PMAA corona is the key factor for the formation of a compartmentalized IPEC shell.

  DOI：

  10.1021/ma400934n

文献信息

• Cationic copolymers
  申请人：Construction Research & Technology GmbH

  公开号：EP2853550A1

  公开（公告）日：2015-04-01

  The present invention relates to cationic copolymers, a process for the production of these cationic copolymers and the use of these cationic copolymers as dispersants for geopolymer binder systems. The present invention is based on the finding that these cationic copolymers where the cationic charge is due to the presence of certain cyclic and/or polycationic groups are stable towards Hoffmann elimination that would otherwise occur at very high pH values. Moreover, the dispersing effect of cationic polymers can be further enhanced through the addition of polyvalent anions.

  本发明涉及阳离子共聚物、生产这些阳离子共聚物的工艺以及将这些阳离子共聚物用作土工聚合物粘结剂体系的分散剂。 本发明基于以下发现：这些阳离子共聚物的阳离子电荷是由于某些环状和/或多阳离子基团的存在而产生的，它们对霍夫曼消解具有稳定性，否则在极高的 pH 值下就会发生霍夫曼消解。 此外，阳离子聚合物的分散效果还可以通过添加多价阴离子得到进一步增强。
• BI-FUNCTIONAL CO-POLYMER USE FOR OPHTHALMIC AND OTHER TOPICAL AND LOCAL APPLICATIONS
  申请人：Eyeon Particle Sciences LLC

  公开号：EP3246048A1

  公开（公告）日：2017-11-22

  A composition comprising a copolymer having a positively charged, or hydrophobic or covalent bonding moiety and a hydrophilic moiety, for use in a method for prolonging the stability of ocular surface tear film in a subject; wherein said method comprises contacting the surface of the eye with said composition in an amount and for a duration so as to prolong the stability of ocular surface tear film in that subject.

  一种包含共聚物的组合物，该共聚物具有带正电荷、疏水或共价键的分子和亲水性分子，可用于延长受试者眼表泪膜稳定性的方法；其中所述方法包括将所述组合物与眼睛表面接触，接触量和接触时间可延长受试者眼表泪膜的稳定性。
• Bi-functional co-polymer use for ophthalmic and other topical and local applications
  申请人：Eyeon Particle Sciences LLC

  公开号：US10729715B2

  公开（公告）日：2020-08-04

  The invention contemplates a copolymer which is a graft or block copolymer useful to change wettability and surface characteristics of biological surfaces. Methods for use of these formulations and coatings to change wettability and sterically stabilize, and lubricate biological surfaces in a subject, for example, in the treatment of dry eye syndrome, and to prevent adherence of unwanted proteins, for example in the treatment of contact lens intolerance, are provided.

  本发明考虑使用接枝或嵌段共聚物来改变生物表面的润湿性和表面特性。本发明提供了使用这些制剂和涂层来改变润湿性、立体稳定和润滑生物表面的方法，例如用于治疗干眼症，以及用于防止不需要的蛋白质附着，例如用于治疗隐形眼镜不耐症。
• Korshunov,M.A. et al., Journal of Organic Chemistry USSR (English Translation), 1969, vol. 5, # 11, p. 1893 - 1898
  作者：Korshunov,M.A. et al.

  DOI：——

  日期：——
• DRUG DELIVERY PRODUCT AND METHODS
  申请人：University of Massachusetts

  公开号：EP1755567B1

  公开（公告）日：2010-11-03