(1R,2S,3R)-1-(2-(1-benzyl-1H-1,2,4-triazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol hydrochloride | 1054543-53-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三唑并嘧啶类
• 英文名称: (1R,2S,3R)-1-(2-(1-benzyl-1H-1,2,4-triazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol hydrochloride
• 英文别名: (1R,2S,3R)-1-[2-(1-benzyl-1,2,4-triazol-3-yl)-1H-imidazol-5-yl]butane-1,2,3,4-tetrol;hydrochloride
• CAS: 1054543-53-1
• 化学式: C₁₆H₁₉N₅O₄*ClH
• 分子量: 381.819
• InChiKey: SWZKOZNAODEUSC-MBLYYGPHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.11
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  140
• 氢给体数：
  6
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  1-benzyl-1H-1,2,4-triazole-3-cyanide 在 sodium methylate 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 盐酸 、 甲醇 为溶剂， 生成 (1R,2S,3R)-1-(2-(1-benzyl-1H-1,2,4-triazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol hydrochloride
  参考文献：
  名称：

  S1P LYASE INHIBITORS FOR THE TREATMENT OF CEREBRAL MALARIA

  摘要：

  揭示了用于治疗、管理和/或预防脑疟疾的方法和组合物。

  公开号：

  US20100113530A1

文献信息

• COMBINATIONS COMPRISING BICYCLIC S1P LYASE INHIBITORS
  申请人：Oravecz Tamas

  公开号：US20100048649A1

  公开（公告）日：2010-02-25

  Methods and compositions for treating immunological and inflammatory diseases and disorders are disclosed. Particular methods and compositions comprise the administration of an agent that inhibits S1P lyase activity and at least one additional immunosuppressive and/or anti-inflammatory agent.

  本发明涉及用于治疗免疫和炎症性疾病和紊乱的方法和组合物。具体方法和组合物包括给予一种抑制S1P裂解酶活性的药物以及至少一种额外的免疫抑制和/或抗炎药物。
• HETEROCYCLIC COMPOUNDS, COMPOSITIONS COMPRISING THEM AND METHODS OF THEIR USE
  申请人：Lexicon Pharmaceuticals, Inc.

  公开号：EP2125788B1

  公开（公告）日：2011-04-06
• Heterocyclic Compounds, Compositions Comprising Them and Methods of Their Use
  申请人：Augeri David J.

  公开号：US20090030050A1

  公开（公告）日：2009-01-29

  Heterocyclic compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of inflammatory and autoimmune diseases and disorders are disclosed. Particular compounds are of formula I:
• METHODS OF TREATING AUTOIMMUNE AND INFLAMMATORY DISEASES AND DISORDERS
  申请人：Augeri David J.

  公开号：US20110082178A1

  公开（公告）日：2011-04-07

  Heterocyclic compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of inflammatory and autoimmune diseases and disorders are disclosed. Particular compounds are of formula I:
• COMPOSITIONS AND METHODS FOR TREATING DEGENERATIVE MUSCLE CONDITIONS
  申请人：University of Washington

  公开号：US20140051729A1

  公开（公告）日：2014-02-20

  Methods and compositions for treating degenerative muscle conditions are disclosed. The compositions disclosed herein include S1P promoting compositions that include an S1P promoting agent. Embodiments of the methods disclosed herein include administering therapeutically effective amounts to subjects suffering from a degenerative muscle condition, such as, for example, subjects suffering from sarcopenia and subjects suffering from muscular dystrophy, including subjects suffering from Duchenne Muscular Dystrophy and Becker Muscular Dystrophy.