1-(phenyltelluro)-1-heptyne | 153581-12-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(phenyltelluro)-1-heptyne
• 英文别名: hept-1-yn-1-yl(phenyl)tellane；Hept-1-ynyltellanylbenzene
• CAS: 153581-12-5
• 化学式: C₁₃H₁₆Te
• 分子量: 299.87
• InChiKey: KNEVNVRJTVLYTJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.56
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  碘苯 、 bis(cyclohexanyl)borane 、 1-(phenyltelluro)-1-heptyne 在 四(三苯基膦)钯 sodium hydroxide 作用下， 生成 、 、
  参考文献：
  名称：

  Vinylborane and vinylchalcogenide mediated synthesis of tri- and tetrasubstituted olefins from 1-alkynes

  摘要：

  The title olefins have been prepared with high regio- and stereocontrol from I-alkynes through vinyl boranes / vinyl chalcogenides; the reaction sequences involved protonolysis or transmetallation - alkylation of the boranes followed by an Ni(0) catalyzed coupling reaction. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)01938-8
• 作为产物：
  描述：

  1-碘-1-庚炔 、 正丁基苯基碲化物 在 copper(l) iodide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以47%的产率得到1-(phenyltelluro)-1-heptyne
  参考文献：
  名称：

  Csp3-tellurium copper cross-coupling: synthesis of alkynyl tellurides a novel class of antidepressive-like compounds

  摘要：

  We present here the results on the synthesis of functionalized alkynyl tellurides using the reaction of vinyl, alkynyl, and aryl tellurides with several alkynyl iodides catalyzed by copper iodide. The reaction proceeded cleanly under mild reaction conditions, at room temperature, in the absence of base and ligand giving alkynyl tellurides in acceptable yields. The obtained compounds 3a-c and 3m-o were screened for antidepressive-like activity using the tail Suspension test (TST) in mice. Compounds 3a-c and 3m-o administered at 10 mg/kg by oral route produced a significant antidepressant-like effect on the TST in mice. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.12.024

文献信息

• Chalcogen electrophile induced rearrangement of 1-alkynyltrialkyl borates: controlled syntheses of trisubstituted olefins from 1-alkynes
  作者：Julien Gerard、László Hevesi

  DOI：10.1016/s0040-4020(01)00904-8

  日期：2001.10

  The reaction of 1-alkynyltrialkyl borates with sulfenyl, selenenyl and tellurenyl halides produces β-chalcogeno alkenylboranes in good yields, with a cis relationship between the boron and the chalcogen moities. Protodeborylation of these compounds by acetic acid, or by a transmetalation–protonolysis sequence, leads to vinyl chalcogenides, which can be converted to alkenes by means of a nickel catalyzed

  1-炔基三烷基硼酸酯与亚硫基，亚硒基和碲基卤化物的反应以良好的产率产生β-硫属元素烯基硼烷，其中硼与硫属元素之间具有顺式关系。这些化合物通过乙酸或通过金属转移-质子分解序列进行原脱硼化反应，生成乙烯基硫属元素化物，可以通过镍与格利雅试剂的偶联将其转化为烯烃。由于最后两个步骤是在保留立体化学的情况下发生的，因此整个序列代表了高度区域和立体选择性的烯烃合成。
• Synthesis of alkynyltellurides mediated by K₃PO₄ and DMSO
  作者：Manoela do Sacramento、Larissa Menezes、Bruna Goldani、Gelson Perin、Marcio S. Silva、Thiago Barcellos、Diego Alves

  DOI：10.1039/c9nj01995b

  日期：——

  In the present work, a simple method for the synthesis of alkynyltellurides is described by the reactions of terminal alkynes with diorganyl ditellurides in the presence of a catalytic amount of K3PO4. In both substrates, it was possible to vary the aryl and alkyl groups, obtaining the products of interest in short reaction times and in yields ranging from 30 to 93%. This methodology, different from

  在目前的工作中，描述了一种简单的合成炔基碲化物的方法，该方法是在催化量的K 3 PO 4存在下，末端炔烃与二有机基二碲化物反应。在两种底物中，都可以改变芳基和烷基，从而以较短的反应时间和30％至93％的产率获得目标产物。该方法与文献中已经报道的方法不同，具有使用催化量的弱碱而不使用金属催化剂的优点。
• Convenient preparation of alkynyl selenides, sulfides and tellurides from terminal alkynes and prenylchalcogenyl halides in the presence of copper(I) iodide
  作者：Antonio L. Braga、Claudio C. Silviera、Aurélia Reckziegel、Paulo H. Menezes

  DOI：10.1016/s0040-4039(00)61445-4

  日期：1993.12

  Alkynyl selenides, sulfides and tellurides were obtained under very mild conditions by reacting terminal alkynes with phenylchalcogenyl halides in the presence of copper iodide(I).

  炔基硒化物，硫化物和碲化物是在非常温和的条件下，通过使末端炔烃与苯基硫属酰基卤化物在碘化铜（I）存在下反应而获得的。
• Palladium-catalyzed Sonogashira cross-coupling of organic tellurides with alkynes
  作者：Shin-ichi Kawaguchi、Puneet Srivastava、Lars Engman

  DOI：10.1016/j.tetlet.2011.05.134

  日期：2011.8

  Alkyl aryl tellurides and a tellurol ester were used as coupling partners in Pd(0)-catalyzed Sonogashira reactions. Microwave-assisted reactions of alkyl aryl tellurides with alkynes in the presence of Cut and catalytic amounts of Pd(PPh(3))(4) produced alkynyl arenes. Similarly, a tellurol ester on reaction with alkynes afforded alkynyl phenyl ketones in the presence of Cut and a catalytic amount of Pd(PPh(3))(4) at room temperature. (C) 2011 Elsevier Ltd. All rights reserved.