3,5-diamino-N-(3,5-diaminophenyl)benzamide | 58338-56-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,5-diamino-N-(3,5-diaminophenyl)benzamide
• CAS: 58338-56-0
• 化学式: C₁₃H₁₅N₅O
• 分子量: 257.295
• InChiKey: SRAIPROVPBDQRW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  133
• 氢给体数：
  5
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3,5-diamino-N-(3,5-diaminophenyl)benzamide 、 溴乙酰溴 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以60%的产率得到N-[3,5-Bis-(2-bromo-acetylamino)-phenyl]-3,5-bis-(2-bromo-acetylamino)-benzamide
  参考文献：
  名称：

  Template Assembled Synthetic Proteins (TASPs). Are Template Size, Shape, and Directionality Important in Formation of Four-Helix Bundles?

  摘要：

  A series of rigid aromatic templates that vary in size, shape, and directionality have been investigated in template-assembled synthetic 4 alpha-helix peptide bundles for their capacity to enhance the alpha-helicity of an amphiphilic peptide (DAATALANALKKL-[NHCH2CH2SH]). In aqueous phosphate buffer (10 mM, pH 7) the peptide has some innate helicity (similar to 30%) which is concentration-independent between 1 and 250 mu M. Helicity is enhanced to 64-75% when 4 equiv of the peptide are connected to aromatic templates based on benzene, benzanilide, or a cyclic octapeptide. This effect is concentration-independent by circular dichroism spectroscopy (3-60 mu M [TASP]), the TASPs are monomeric by sedimentation equilibrium experiments, and have comparable thermodynamic stabilities. Thus these templates induce intra-rather than inter-molecular peptide association and are equally effective despite variations in size, shapes and directionality. When the linker between the template and peptides is sufficently long, as in these cases, TASP formation is less sensitive to the dimensions of the template than to the communication between hydrophobic peptide side chains, which are the main determinants of helix separation, 4 alpha-helix bundle size and stability. This greatly simplifies approaches to developing small molecule mimetics of interacting protein surfaces. However template size, shape, and directionality may still be important when the linker is short or when assembled peptide surfaces are isolated from one another and unable to communicate.

  DOI：

  10.1021/ja971951o

文献信息

• MEMBRANE, APPARATUS, AND ASSOCIATED METHOD
  申请人：Yeager Gary William

  公开号：US20080203012A1

  公开（公告）日：2008-08-28

  A membrane is provided that is formed from a composition. The composition comprises a polyarylene ether polymer or copolymer comprising a zwitterion; or comprises a polyarylene polymer or copolymer comprising a zwitterion.

  提供了一种由成分形成的膜。该成分包括聚芳醚聚合物或共聚物，其中包括一个带有离子对的分子；或包括聚芳醚聚合物或共聚物，其中包括一个带有离子对的分子。
• COMPOSITION AND ASSOCIATED METHOD
  申请人：Yeager Gary William

  公开号：US20080207822A1

  公开（公告）日：2008-08-28

  Provided is a composition including a polyarylene ether polymer or copolymer comprising a zwitterionic, group. The zwitterionic group can derive from a zwitterionic precursor such as 4-(2-hydroxyethyl)-1-piperazine ethane sulfonic acid and comprises at least one atom of sulfur, phosphorus, or nitrogen. Embodiments also relate to an article, made from the composition, such as a membrane.

  提供的是一种化合物，其中包括聚芳醚聚合物或共聚物，其中包含一个带有两性离子基团。这个两性离子基团可以来自于两性离子前体，例如4-(2-羟乙基)-1-哌嗪乙烷磺酸，且至少包含一个硫、磷或氮原子。实施例还涉及使用该化合物制成的物品，例如膜。
• METHOD OF MAKING AND USING MEMBRANE
  申请人：Yeager Gary William

  公开号：US20080312349A1

  公开（公告）日：2008-12-18

  A process is provided that includes attaching a zwitterion to a polymer or a copolymer, wherein the polymer or copolymer comprises a polyarylene ether or a polyarylene.

  提供的过程包括将一种内盐离子（zwitterion）附着在聚合物或共聚物上，其中该聚合物或共聚物包括聚芳醚或聚芳烃。
• [EN] COMPOSITION, ITS USE IN THE PREPARATION OF MEMBRANES, AND SYSTEMS COMPRISING THE MEMBRANES<br/>[FR] COMPOSITION, UTILISATION DE CELLE-CI DANS LA PRÉPARATION DE MEMBRANES ET SYSTÈMES COMPRENANT DE TELLES MEMBRANES
  申请人：SABIC INNOVATIVE PLASTICS IP

  公开号：WO2008103599A2

  公开（公告）日：2008-08-28

  [EN] Provided is a composition including a polyarylene ether polymer or copolymer comprising a zwitterion, or a polyarylene polymer or copolymer comprising a zwitterion. Also provided is a process that includes attaching a zwitterion to a polymer or a copolymer, wherein the polymer or copolymer comprises a polyarylene ether or a polyarylene. Also provided is a membrane that is formed from the composition.
  [FR] La présente invention concerne une composition comprenant un polymère ou un copolymère de polyarylène éther comprenant un zwitterion, ou un polymère ou un copolymère de polyarylène comprenant un zwitterion. Cette invention concerne également un procédé qui consiste à lier un zwitterion à un polymère ou à un copolymère comprenant un polyarylène éther ou un polyarylène. En outre, cette invention concerne une membrane qui est produite à partir de ladite composition.