1-Carboxymethyl-2-thio-uracil, <4-Oxo-2-thioxo-3,4-dihydro-2H-pyrimidin-1yl>-essigsaeure | 1199-27-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-Carboxymethyl-2-thio-uracil, <4-Oxo-2-thioxo-3,4-dihydro-2H-pyrimidin-1yl>-essigsaeure
• 英文别名: (4-oxo-2-thioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetic acid；2-(4-Oxo-2-sulfanylidenepyrimidin-1-yl)acetic acid
• CAS: 1199-27-5
• 化学式: C₆H₆N₂O₃S
• 分子量: 186.191
• InChiKey: VEVSGTOPHYWDIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  102
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Quantification of single target molecules in histological samples
  申请人：Lohse Jesper

  公开号：US10180426B2

  公开（公告）日：2019-01-15

  The present invention lies in the field of visualization and quantification of immobilized targets in samples using immunochemical means. The methods of the invention utilize an immunostaining system allowing visualizing single target units in samples as distinct dots. In particular, the invention relates to methods and reagents for visualization and quantification of molecular targets immunostained in histological samples and use of said method and reagents in medical diagnostic. However, the visualization and quantification methods of the invention are applicable to a variety of targets in different samples and allow precise quantifying both relative and absolute amounts thereof.

  本发明属于利用免疫化学方法对样品中的固定靶标进行可视化和量化的领域。本发明的方法利用一种免疫染色系统，可将样品中的单个目标单位可视化为不同的点。特别是，本发明涉及对组织学样本中免疫染色的分子靶标进行可视化和定量的方法和试剂，以及上述方法和试剂在医学诊断中的应用。不过，本发明的可视化和定量方法适用于不同样本中的各种靶标，并可精确定量其相对量和绝对量。
• Method for evaluation of target in histological sample
  申请人：DAKO DENMARK A/S

  公开号：US10648970B2

  公开（公告）日：2020-05-12

  The present invention lies in the field of visualization and quantification of immobilized targets in samples using immunochemical means. In particular, the invention relates to a method and reagents for detection, visualization and quantification of a molecular target in immunostained histological samples using particular compositions of the target specific binding agent. Methods and compositions of the invention are suitable for any assay that uses a target visualization system in histological samples based on detection of the target by the target specific binding agent. The methods and compositions are useful for evaluation of targets that are biomarkers of diseases in medical diagnostic.

  本发明属于利用免疫化学手段对样品中固定靶标进行可视化和定量的领域。特别是，本发明涉及一种方法和试剂，利用目标特异性结合剂的特定组合物对免疫染色组织学样本中的分子目标进行检测、可视化和定量。本发明的方法和组合物适用于在组织学样本中使用基于靶标特异性结合剂检测靶标的靶标可视化系统的任何检测。本发明的方法和组合物适用于评估医学诊断中作为疾病生物标志物的靶标。
• METHODS AND COMPOUNDS FOR DETECTION OF MOLECULAR TARGETS
  申请人：Dako Denmark A/S

  公开号：EP2398908B1

  公开（公告）日：2013-08-21
• IMMUNOCHEMICAL DETECTION OF SINGLE TARGET ENTITIES
  申请人：Dako Denmark A/S

  公开号：EP2491390B1

  公开（公告）日：2014-03-26
• QUANTIFICATION OF SINGLE TARGET MOLECULES IN HISTOLOGICAL SAMPLES
  申请人：Dako Denmark A/S

  公开号：EP2638392B1

  公开（公告）日：2016-01-13