3-[2'(S)-benzyl-3'-mercaptopropionyl]-4(S)-carboxy-5,5-dimethylthiazolidine | 188636-20-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-[2'(S)-benzyl-3'-mercaptopropionyl]-4(S)-carboxy-5,5-dimethylthiazolidine
• 英文别名: (4S)-3-[(2S)-2-benzyl-3-sulfanylpropanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
• CAS: 188636-20-6
• 化学式: C₁₆H₂₁NO₃S₂
• 分子量: 339.48
• InChiKey: DBAXHUJPNUIUCI-OLZOCXBDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  83.9
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Inhibition of metallo-beta-lactamase
  申请人：Shaw W. Robert

  公开号：US20050202434A1

  公开（公告）日：2005-09-15

  A method to identify a high affinity nucleic acid ligand to inhibit the activity of a lactamase enzyme. The method comprises several steps that initially involve preparing a candidate mixture of nucleic acids. The candidate mixture of nucleic acids is then allowed to make contact with the lactamase enzyme under controlled conditions of temperature, ionic strength and pH; the combination forms a candidate-enzyme mixture. The target nucleic acids are partitioned from the remainder of the candidate mixture. The target nucleic acids that have been partitioned are amplified to yield a pool of nucleic acids enriched with target nucleic acid sequences. The enriched pool of target nucleic acids have a relatively higher affinity and specificity for binding to the lactamase, whereby nucleic acid ligand of the lactamase are identified. Nucleic acid ligands that inhibit an activity of lactamase. The lactamase includes class B, metallo-β-lactamase.

  一种鉴定抑制内酰胺酶活性的高亲和性核酸配体的方法。该方法包括几个步骤，首先是制备候选核酸混合物。然后，在控制温度、离子强度和 pH 值的条件下，让候选核酸混合物与内酰胺酶接触；两者结合形成候选酶混合物。目标核酸从候选混合物的剩余部分中分离出来。扩增已分配的靶核酸，以产生富含靶核酸序列的核酸池。富集后的靶核酸池与内酰胺酶的结合亲和力和特异性相对较高，从而鉴定出内酰胺酶的核酸配体。抑制内酰胺酶活性的核酸配体。内酰胺酶包括 B 类金属-β-内酰胺酶。
• INHIBITION OF METALLO-BETA-LACTAMASE
  申请人：Shaw Robert W.

  公开号：US20090203003A1

  公开（公告）日：2009-08-13

  A method to identify a high affinity nucleic acid ligand to inhibit the activity of a lactamase enzyme. The method comprises several steps that initially involve preparing a candidate mixture of nucleic acids. The candidate mixture of nucleic acids is then allowed to make contact with the lactamase enzyme under controlled conditions of temperature, ionic strength and pH; the combination forms a candidate-enzyme mixture. The target nucleic acids are partitioned from the remainder of the candidate mixture. The target nucleic acids that have been partitioned are amplified to yield a pool of nucleic acids enriched with target nucleic acid sequences. The enriched pool of target nucleic acids have a relatively higher affinity and specificity for binding to the lactamase, whereby nucleic acid ligand of the lactamase are identified. Nucleic acid ligands that inhibit an activity of lactamase. The lactamase includes class B, metallo-β-lactamase.
• US6022885A
  申请人：——

  公开号：US6022885A

  公开（公告）日：2000-02-08
• US7456274B2
  申请人：——

  公开号：US7456274B2

  公开（公告）日：2008-11-25
• US7772388B2
  申请人：——

  公开号：US7772388B2

  公开（公告）日：2010-08-10