3-(2-cyanophenyl)-1-phenyl-5-(tri-n-butyl stannyl)-1,2-dihydropyridin-2-one | 381250-74-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-(2-cyanophenyl)-1-phenyl-5-(tri-n-butyl stannyl)-1,2-dihydropyridin-2-one
• 英文别名: 2-(2-oxo-1-phenyl-5-tributylstannylpyridin-3-yl)benzonitrile
• CAS: 381250-74-4
• 化学式: C₃₀H₃₈N₂OSn
• 分子量: 561.355
• InChiKey: OWGUJMFIWYHPNC-UHFFFAOYSA-N

物化性质

• 沸点：
  601.6±65.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.43
• 重原子数：
  34
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  44.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(2-cyanophenyl)-1-phenyl-5-(tri-n-butyl stannyl)-1,2-dihydropyridin-2-one 、 6-氯-3-吡啶基乙酸酯 在 三苯基膦钯 作用下， 以 5,5-dimethyl-1,3-cyclohexadiene 为溶剂， 生成 5-(5-acetoxypyridin-2-yl)-3-(2-cyanophenyl)-1-phenyl-1,2-dihydropyridin-2-one
  参考文献：
  名称：

  1,2-DIHYDROPYRIDINE COMPOUNDS, PROCESS FOR PREPARATION OF THE SAME AND USE THEREOF

  摘要：

  公开号：

  EP1300396B1

文献信息

• 1, 2-Dihydropyridine compounds, manufacturing method thereof and use thereof
  申请人：Nagato Satoshi

  公开号：US20050245581A1

  公开（公告）日：2005-11-03

  The present invention provides a novel compound having an excellent AMPA receptor inhibitory action and/or kainate inhibitory action. A compound represented by the following formula, a salt thereof or hydrates thereof. In the formula, Q indicates NH, O or S; and R 1 , R 2 , R 3 , R 4 and R 5 are the same as or different from each other and each indicates hydrogen atom, a halogen atom, a C 1-6 alkyl group or a group represented by the formula —X-A (wherein X indicates a single bond, an optionally sbutituted C 1-6 alkylene group etc.; and A indicates an optionally substituted C 6-14 aromatic hydrocarbocyclic group or 5- to 14-membered aromatic heterocyclic group etc.).

  本发明提供了一种具有出色的AMPA受体抑制作用和/或kainate抑制作用的新型化合物。该化合物由以下式表示，其盐或水合物。在该式中，Q表示NH，O或S；R1、R2、R3、R4和R5相同或不同，每个表示氢原子，卤素原子，C1-6烷基或由式—X-A表示的基团（其中X表示单键，可选地取代的C1-6烷基等；A表示可选地取代的C6-14芳香烃环基团或5-至14成员的芳香杂环基团等）。
• 1,2-DIHYDROPYRIDINE COMPOUNDS, MANUFACTURING METHOD THEREOF AND USE THEREOF
  申请人：NAGATO Satoshi

  公开号：US20090275751A1

  公开（公告）日：2009-11-05

  The present invention provides a novel compound having an excellent AMPA receptor inhibitory action and/or kainate inhibitory action. A compound represented by the following formula, a salt thereof or hydrates thereof. In the formula, Q indicates NH, O or S; and R 1 , R 2 , R 3 , R 4 and R 5 are the same as or different from each other and each indicates hydrogen atom, a halogen atom, a C 1-6 alkyl group or a group represented by the formula —X-A (wherein X indicates a single bond, an optionally substituted C 1-6 alkylene group etc.; and A indicates an optionally substituted C 6-14 aromatic hydrocarbocyclic group or 5- to 14-membered aromatic heterocyclic group etc.).

  本发明提供了一种新型化合物，具有优异的AMPA受体抑制作用和/或kainate抑制作用。该化合物的化学式如下，其盐或水合物：在该式中，Q表示NH、O或S；R1、R2、R3、R4和R5相同或不同，且每个表示氢原子、卤素原子、C1-6烷基或由式—X-A表示的基团（其中X表示单键、可选地取代的C1-6烷基等；A表示可选地取代的C6-14芳香烃环基或5-至14元杂环芳香族基等）。
• 1,2-dihydropyridine compounds, process for preparation of the same and use thereof
  申请人：Nagato Satoshi

  公开号：US06949571B2

  公开（公告）日：2005-09-27

  The present invention provides a novel compound having an excellent AMPA receptor inhibitory action and/or kainate inhibitory action. A compound represented by the following formula, a salt thereof or hydrates thereof. In the formula, Q indicates NH, O or S; and R 1 , R 2 , R 3 , R 4 and R 5 are the same as or different from each other and each indicates hydrogen atom, a halogen atom, a C 1-6 alkyl group or a group represented by the formula —X-A (wherein X indicates a single bond, an optionally substituted C 1-6 alkylene group etc.; and A indicates an optionally substituted C 6-14 aromatic hydrocarbocyclic group or 5- to 14-membered aromatic heterocyclic group etc.).

  本发明提供了一种新型化合物，具有优异的AMPA受体抑制作用和/或kainate抑制作用。该化合物由以下公式表示，其盐或水合物。在该公式中，Q表示NH、O或S；而R1、R2、R3、R4和R5相同或不同，每个表示氢原子、卤素原子、C1-6烷基或由公式—X-A表示的基团（其中X表示单键、可选取代的C1-6烷基等；A表示可选取代的C6-14芳香烃环基或5-至14成员的芳香杂环基等）。
• Pharmaceutical compositions and their uses
  申请人：Eisai R&D Management Co., Ltd.

  公开号：US07759367B2

  公开（公告）日：2010-07-20

  The present invention relates to compositions comprising 1,2-dihydropiridin-2-one compounds and an immunoregulatory or anti-inflammatory agent. The compositions are useful for the prevention or the treatment of neurodegenerative diseases, for example demyelinating disorders.

  本发明涉及包含1,2-二氢吡啶-2-酮化合物和免疫调节或抗炎药物的组合物。该组合物可用于预防或治疗神经退行性疾病，例如脱髓鞘性疾病。
• 1,2-dihydropyridine compounds, manufacturing method thereof and use thereof
  申请人：Eisai R&D Management Co., Ltd.

  公开号：US07563811B2

  公开（公告）日：2009-07-21

  The present invention provides a novel compound having an excellent AMPA receptor inhibitory action and/or kainate inhibitory action. A compound represented by the following formula, a salt thereof or hydrates thereof. In the formula, Q indicates NH, O or S; and R1, R2, R3, R4 and R5 are the same as or different from each other and each indicates hydrogen atom, a halogen atom, a C1-6 alkyl group or a group represented by the formula —X-A (wherein X indicates a single bond, an optionally substituted C1-6 alkylene group etc.; and A indicates an optionally substituted C6-14 aromatic hydrocarbocyclic group or 5- to 14-membered aromatic heterocyclic group etc.).

  本发明提供了一种具有优异的AMPA受体抑制作用和/或kainate抑制作用的新型化合物。该化合物的表示式如下，其盐或水合物。在该式中，Q表示NH、O或S；R1、R2、R3、R4和R5相同或不同，每个表示氢原子、卤原子、C1-6烷基或由式—X-A表示的基团（其中X表示单键、可选地取代的C1-6烷基等；A表示可选地取代的C6-14芳香烃环基或5-至14元芳香杂环基等）。