Poly(oxy-1,2-ethanediyl), I+/--(3-carboxy-1-oxo-3-sulfopropyl)-I-hydroxy- | 148276-25-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Poly(oxy-1,2-ethanediyl), I+/--(3-carboxy-1-oxo-3-sulfopropyl)-I-hydroxy-
• 英文别名: 4-(2-hydroxyethoxy)-4-oxo-2-sulfobutanoic acid
• CAS: 148276-25-9
• 化学式: C₆H₁₀O₈S
• 分子量: 242.21
• InChiKey: GRDRXARYUFQZFL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  147
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• EXTERNAL PREPARATION FOR SKIN AND CLEANSING AGENT FOR SKIN
  申请人：SHISEIDO COMPANY, LTD.

  公开号：EP2082729A1

  公开（公告）日：2009-07-29

  The present invention was made in view of the above-described circumstances, and an object of the invention is to provide an external skin preparation having a rough skin improving effect, excellent in texture in use, especially excellent in smoothness, free of sticky feeling, and excellent in stability. Another object is to provide a skin cleanser excellent especially in usability and a cosmetic removing effect. That is, the external skin preparation of the present invention is characterized by comprising a block-type alkylene oxide derivative represented by the below-described formula (I).         [formula 1] Y-[O(EO)a-(AO)b-(EO)o-R]k     (I) (In the formula, Y is the residue given by removing hydroxyl groups from a polyhydric alcohol having 3 to 6 hydroxyl groups, and k is the number of hydroxyl groups of the polyhydric alcohol. EO is an oxyethylene group, AO is an oxyalkylene group having 3 to 6 carbon atoms, and they are attached in a block-type, respectively. The products, a×k, b×k, and c×k, are the average addition mole numbers of the oxyethylene group, the oxyalkylene group having 3 to 6 carbon atoms, and the oxyethylene group, respectively, and 0 ≦a×k≦ 100, 1≦b×k≦ 100, and 0≦c×k≦ 100, however, (a+c)×k>1. The percentage of all oxyethylene groups in formula (I) with respect to the sum of all oxyethylene groups and oxyalkylene groups having 3 to 6 carbon atoms in formula (I) is 10 to 80 mass %. Rs may be either identical to or different from each other, and they are hydrocarbon groups with 1 to 4 carbon atoms.) The skin cleanser of present invention is characterized by comprising 0.01 to 70 mass % of a block-type alkylene oxide derivative represented by the above-described formula (I) and 0.1 to 20 mass % of a moisturizer.

  本发明是鉴于上述情况而提出的，其目的是提供一种外用皮肤制剂，该制剂具有改善皮肤粗糙的效果，使用时质地优良，特别是光滑度优良，无粘腻感，稳定性优良。本发明的另一个目的是提供一种皮肤清洁剂，其使用性和化妆品去除效果尤为出色。 也就是说，本发明的外用护肤制剂的特点是包含由下述式（I）表示的块状环氧烷衍生物。 [式 1] Y-[O(EO)a-(AO)b-(EO)o-R]k (I) (式中：Y 为从具有 3 至 6 个羟基的多元醇中去除羟基后的残留物，k 为多元醇的羟基数。EO 是氧乙烯基，AO 是具有 3 至 6 个碳原子的氧亚烷基，它们分别以块状连接。产物 a×k、b×k 和 c×k 分别是氧乙烯基、具有 3 至 6 个碳原子的氧亚烃基和氧乙烯基的平均加和摩尔数，且 0 ≦a×k≦100、1≦b×k≦100 和 0≦c×k≦100，但 (a+c)×k>1 。式(I)中所有氧乙烯基团占式(I)中所有氧乙烯基团和具有 3 至 6 个碳原子的氧亚烃基团之和的百分比为 10 至 80 质量%。Rs既可以相互相同，也可以相互不同，它们都是具有 1 至 4 个碳原子的烃基团）。 本发明洁肤剂的特点是含有 0.01 至 70 质量％的由上述式（I）代表的块状环氧烷衍生物和 0.1 至 20 质量％的保湿剂。
• OIL IN WATER EMULSION COSMETIC MATERIAL FOR SKIN
  申请人：Shiseido Company, Ltd.

  公开号：EP2314279A1

  公开（公告）日：2011-04-27

  Problem: To provide an oil in water emulsion cosmetic composition for skin, in which vitamin A and its derivatives are stably incorporated and which has superior feeling in use (skin familiarity or feeling of skin absorption, feeling of efficacy after application) and base composition stability (emulsion stability) with the passage of time. Means for Resolution: An oil in water emulsion cosmetic composition for skin comprising, relative to the total amount of the cosmetic composition, (a) from 0.01 to 4% by mass of vitamin A and its derivative, (b) from 0.6 to 4% by mass of a nonionic surfactant comprising three of (b-1) sorbitan tristearate, (b-2) polyethylene glycol stearate with from 20 to 120 mols of polyethylene glycol added thereto, (b-3) glyceryl stearate having an HLB of from 5 to 8, and (c) from 1 to 10% by mass of a higher alcohol having from 14 to 24 carbon atoms, wherein the blend ratio (by mass) of component (b-1) to component (b) is from 0.1 to 0.8.

  问题：提供一种用于皮肤的水包油型乳液化妆品组合物，其中稳定地掺入了维生素 A 及其衍生物，并且随着时间的推移，其使用感（皮肤熟悉感或皮肤吸收感、涂抹后的功效感）和基础组合物稳定性（乳液稳定性）均更佳。 解决方法一种用于皮肤的水包油型乳液化妆品组合物，相对于该化妆品组合物的总量，它包含：(a) 0.01 至 4%（质量百分比）的维生素 A 及其衍生物；(b) 0.6%至 4%（质量百分比）的非离子表面活性剂，包括 (b-1) 山梨坦三硬脂酸酯、(b-2) 加入 20 至 120 摩尔聚乙二醇的聚乙二醇硬脂酸酯、(b-3) HLB 为 5 至 8 的甘油硬脂酸酯和 (c) 1 至 10%（质量百分比）的具有 14 至 24 个碳原子的高级醇，其中组分 (b-1) 与组分 (b) 的混合比（质量百分比）为 0.1 至 0.8。
• GEL-LIKE COMPOSITION FOR COSMETIC PREPARATIONS
  申请人：Adeka Corporation

  公开号：EP3006018A1

  公开（公告）日：2016-04-13

  An object of the present invention is to provide a gel that is not destroyed by a change in pH or by the addition of a salt into the gel, gives a feeling of use equivalent to that of a gel produced using an alkali thickening type gelling agent, and can be used for a cosmetic preparation. In order to achieve the above-mentioned object, the present invention provides a gel-like composition for a cosmetic preparation including 0. 05 part by mass to 3 parts by mass of a compound represented by the following general formula (1) with respect to 100 parts by mass of water. (Where, R1 and R2 each represent an alkyl group having 28 to 36 carbon atoms, R3 and R4 each represent a hydrocarbon group having 4 to 13 carbon atoms, m and n each represent a number from 10 to 500, x represents a number from 1 to 1,000, and y represents a number from 0 to 10.)

  本发明的目的是提供一种凝胶，该凝胶不会因 pH 值变化或向凝胶中添加盐而被破坏，使用感与使用碱增稠型胶凝剂生产的凝胶相当，并可用于化妆品制剂。为了达到上述目的，本发明提供了一种用于化妆品制剂的凝胶状组合物，该组合物包括 0.05 质量份至 3 质量份由以下通式（1）代表的化合物（相对于 100 质量份的水）。 (其中，R1 和 R2 分别代表具有 28 至 36 个碳原子的烷基，R3 和 R4 分别代表具有 4 至 13 个碳原子的烃基，m 和 n 分别代表 10 至 500 之间的数字，x 代表 1 至 1,000 之间的数字，y 代表 0 至 10 之间的数字）。
• COMPOSITION CONTAINING POWDER
  申请人：Nissan Chemical Corporation

  公开号：EP3738578A1

  公开（公告）日：2020-11-18

  There is provided a composition that contains powder in a dispersed state and enables the powder to rapidly disperse in water. A composition comprising a lipidic peptide gelator composed of at least one of compounds of the following Formula (1) or pharmaceutically usable salts of the compounds: (wherein R1 is a C9-23 aliphatic group; R2 is a hydrogen atom or a C1-4 alkyl group optionally having a Ci or C2 branched chain; and R3 is a -(CH2)n-X group, wherein n is a number of 1 to 4, and X is an amino group, a guanidino group, a -CONH2 group, or a 5-membered ring or 6-membered ring optionally having one to three nitrogen atoms or a fused heterocyclic ring composed of the 5-membered ring and the 6-membered ring); water; a fatty acid salt; an acidic low-molecular-weight compound; a surfactant; and powder.

  本发明提供了一种组合物，该组合物含有分散状态的粉末，并能使粉末在水中快速分散。 一种包含脂肽凝胶剂的组合物，该凝胶剂由至少一种下式（1）化合物或这些化合物的药用盐组成： (其中 R1 是 C9-23 脂肪族基团；R2 是氢原子或任选具有 Ci 或 C2 支链的 C1-4 烷基；其中 R1 是 C9-23 脂肪族基团；R2 是氢原子或任选具有 Ci 或 C2 支链的 C1-4 烷基；和 R3 是-(CH2)n-X 基团，其中 n 是 1 至 4 的数字，和 X 是氨基、胍基、-CONH2 基团或任选具有 1 至 3 个氮原子的 5 元环或 6 元环或由 5 元环和 6 元环组成的融合杂环）；水；脂肪酸盐；酸性低分子量化合物；表面活性剂；和粉末。
• External skin treatment composition
  申请人：SHISEIDO COMPANY, LTD.

  公开号：EP0815838B1

  公开（公告）日：2004-04-28