3-methyl-1,1'-biphenyl-2-carbonitrile | 37580-52-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-methyl-1,1'-biphenyl-2-carbonitrile
• 英文别名: 3-Methyl-2-biphenylcarbonitril；3-Methylbiphenyl-2-carbonitril；Methylcyanobi-phenyl；2-methyl-6-phenylbenzonitrile
• CAS: 37580-52-2
• 化学式: C₁₄H₁₁N
• 分子量: 193.248
• InChiKey: CTTUUXGJIWMJHV-UHFFFAOYSA-N

物化性质

• 沸点：
  352.0±21.0 °C(Predicted)
• 密度：
  1.09±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  23.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-methyl-1,1'-biphenyl-2-carbonitrile 在 sodium hydroxide 作用下， 以 乙二醇 为溶剂， 生成 3-methyl-[1,1'-biphenyl]-2-carboxamide
  参考文献：
  名称：

  半合成青霉素。I.2-联苯苄青霉素。

  摘要：

  DOI：

  10.1021/jm00333a001
• 作为产物：
  描述：

  苯硼酸 在 频哪酮 、 RuH₂(CO)(PPh₃)₃ 、 calcium chloride 、 sodium t-butanolate 作用下， 以 乙醚 为溶剂， 反应 15.5h， 生成 3-methyl-1,1'-biphenyl-2-carbonitrile
  参考文献：
  名称：

  钌催化芳族腈与芳基硼酸酯的邻位C-H芳基化和部分对位芳基化的观察

  摘要：

  描述了钌催化芳香腈与芳基硼酸酯的CH芳基化反应。与常规RuH 2（CO）（PPh 3）3催化剂相比，使用RuH 2（CO）{P（4-MeC 6 H 4）3 } 3作为催化剂可提供更高的邻芳基化产物收率。芳基化主要发生在邻位，但也观察到部分空前的芳基化产生邻位，对二芳基化产物。除了C–H键断裂以外，还发现氰基还充当芳基醚中C–O键断裂的导向基团。

  DOI：

  10.1021/acs.joc.6b02623

文献信息

• [EN] PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS<br/>[FR] COMPOSES DE PYRROLE ET PYRAZOLE PRESENTANT UN EFFET POTENTIATEUR SUR LES RECEPTEURS DU GLUTAMATE
  申请人：LILLY CO ELI

  公开号：WO2005040110A1

  公开（公告）日：2005-05-06

  The present invention relates to pyrrole and pyrazole compounds of formula (I) and their pharmaceutically acceptable salts, and further relates to their use in treating schizophrenia, cognitive deficits associated with schizophrenia, Alzheimer's disease, dementia of the Alzheimer's type, mild cognitive impairment, or depression. The compounds act as potentiators on glutamate receptors, in particular AMPA and the GluR family.

  本发明涉及式(I)的吡咯和吡唑化合物及其药用可接受的盐，并且进一步涉及它们在治疗精神分裂症、与精神分裂症相关的认知缺陷、阿尔茨海默病、阿尔茨海默型痴呆、轻度认知障碍或抑郁症方面的应用。这些化合物作为谷氨酸受体的增强剂，特别是AMPA和GluR家族。
• CONDENSED CYCLIC COMPOUND, COMPOSITION INCLUDING THE CONDENSED CYCLIC COMPOUND, AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING CONDENSED CYCLIC COMPOUND
  申请人：Samsung Electronics Co., Ltd.

  公开号：US20190229276A1

  公开（公告）日：2019-07-25

  A condensed cyclic compound represented by Formula 1: wherein in Formula 1, Ar 11 , Ar 12 , R 11 , R 12 , R 13 , and R 14 are the same as described in the specification.

  由式1表示的一种紧凑的环状化合物：其中在式1中，Ar11、Ar12、R11、R12、R13和R14与规范中描述的相同。
• A new process for the preparation of irbesartan
  申请人：KRKA, tovarna zdravil, d.d., Novo mesto

  公开号：EP2194050A1

  公开（公告）日：2010-06-09

  A process for the preparation of Irbesartan or a pharmaceutically acceptable salt thereof comprising the step of coupling the 1-pentanamidocyclapentanecarboxamide of formula (V) with 4'-substituted methyl biphenyl-2-carbonitrile or 1-(4'-substituted methyl biphenyl-2-yl)-1H-tetrazole wherein tetrazole can be protected or unprotected to obtain the N-[(2'-cyanobiphenyl-4-yl)methyl]-1-pentanamidocyclopentanecarboxamide or N-[1-([2'-(1H-tetrazol-1-yl)biphenyl-4-yl]methylamino)methyl)cydopentyl]pentanamide wherein tetrazole can be protected or unprotected that is further processed to Irbesartan or a pharmaceutical acceptable salt thereof.

  制备厄贝沙坦或其药用可接受盐的方法包括以下步骤：将式（V）的1-戊酰胺环戊烷羧酰胺与4'-取代甲基联苯基-2-碳腈或1-(4'-取代甲基联苯基-2-基)-1H-四唑偶联，其中四唑可以被保护或未被保护，得到N-[(2'-氰基联苯基-4-基)甲基]-1-戊酰胺环戊烷羧酰胺或N-[1-([2'-(1H-四唑-1-基)联苯基-4-基]甲基氨基}甲基)环戊基]戊酰胺，其中四唑可以被保护或未被保护，进一步处理得到厄贝沙坦或其药用可接受盐。
• NOVEL 2-PYRIDONE DERIVATIVE AND PHARMACEUTICAL PRODUCT CONTAINING SAME
  申请人：Miura Toru

  公开号：US20120225896A1

  公开（公告）日：2012-09-06

  Disclosed is a novel 2-pyridone derivative represented by general formula (1), which has both angiotensin II receptor antagonist activity and PPAR-γ activating activity and is useful as a prophylactic and/or therapeutic agent for cardiovascular diseases and metabolic diseases. Also disclosed is a pharmaceutical composition which contains the novel 2-pyridone derivative. In general formula (1), R 1 represents a C 1-6 alkyl group or a C 1-6 alkoxy group; R 2 represents a C 1-6 alkyl group or a C 3-8 cycloalkyl group; R 3 represents a C 1-6 alkyl group, a C 6-10 aryl-C 1-6 alkyl group, a C 1-6 alkoxy-C 1-6 alkyl group or a group represented by formula (2) (wherein A represents a nitrogen atom or CH, and R 5 represents a hydrogen atom or a C 1-6 alkoxy group); and R 4 represents a group represented by formula (3) or (4).

  揭示了一种由通式（1）表示的新型2-吡啶酮衍生物，该衍生物具有抗血管紧张素II受体拮抗活性和PPAR-γ激活活性，并且可用作心血管疾病和代谢性疾病的预防和/或治疗剂。还揭示了一种含有该新型2-吡啶酮衍生物的药物组合物。在通式（1）中，R1代表C1-6烷基或C1-6烷氧基；R2代表C1-6烷基或C3-8环烷基；R3代表C1-6烷基、C6-10芳基-C1-6烷基、C1-6烷氧基-C1-6烷基或由通式（2）表示的基团（其中A代表氮原子或CH，R5代表氢原子或C1-6烷氧基）；R4代表由通式（3）或（4）表示的基团。
• Metal-Free Generation of γ-Cyanoalkyl Radicals by N-Heterocyclic Carbene Catalysis: Assembly of 6-Cyanoalkyl Phenanthridines
  作者：Qianrong Li、Cong-Ying Zhou、Chengming Wang

  DOI：10.1021/acs.orglett.2c03808

  日期：2022.12.23

  number of γ-cyanoalkyl radicals were generated by sustainable N-heterocyclic carbene catalysis in tin-, transition-meal-, and light-free conditions, followed by insertion into biaryl isonitriles, thus leading to the rapid assembly of a variety of diversely functionalized 6-cyanoalkyl phenanthridines. A preliminary mechanism study revealed that a single-electron transfer radical process was possibly involved

  在无锡​​、过渡餐和无光条件下，通过可持续的 N-杂环卡宾催化产生了许多 γ-氰基烷基自由基，然后插入到联芳基异腈中，从而导致各种不同功能化的快速组装6-氰基烷基菲啶。初步的机理研究表明，可能涉及单电子转移自由基过程。