Phosphoric acid diethyl[2-(difluoromethyl)-4-aminophenyl] ester | 429692-37-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Phosphoric acid diethyl[2-(difluoromethyl)-4-aminophenyl] ester
• 英文别名: [4-amino-2-(difluoromethyl)phenyl] diethyl phosphate
• CAS: 429692-37-5
• 化学式: C₁₁H₁₆F₂NO₄P
• 分子量: 295.223
• InChiKey: IYMXEKFBWWDWLV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  70.8
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  Phosphoric acid diethyl[2-(difluoromethyl)-4-aminophenyl] ester 在 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Direct Screening for Phosphatase Activity by Turnover-Based Capture of Protein Catalysts This work was supported by BBSRC studentships (to J.B. and H.D.), by an EPSRC studentship (to J.H.R.), and by an EC TMR studentship (to S.C.-T.).

  摘要：

  DOI：

  10.1002/1521-3773(20020301)41:5<775::aid-anie775>3.0.co;2-f
• 作为产物：
  描述：

  Phosphoric acid diethyl ester 2-formyl-4-nitro-phenyl ester 在 palladium on activated charcoal 二乙胺基三氟化硫 、 氢气 作用下， 反应 0.42h， 生成 Phosphoric acid diethyl[2-(difluoromethyl)-4-aminophenyl] ester
  参考文献：
  名称：

  Direct Screening for Phosphatase Activity by Turnover-Based Capture of Protein Catalysts This work was supported by BBSRC studentships (to J.B. and H.D.), by an EPSRC studentship (to J.H.R.), and by an EC TMR studentship (to S.C.-T.).

  摘要：

  DOI：

  10.1002/1521-3773(20020301)41:5<775::aid-anie775>3.0.co;2-f

文献信息

• [EN] ORGANOTELLURIUM COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF<br/>[FR] COMPOSÉS D'ORGANOTELLURE, LEURS COMPOSITIONS ET MÉTHODES D'UTILISATION
  申请人：UNIV TORONTO

  公开号：WO2016026046A1

  公开（公告）日：2016-02-25

  A compound of formula (I) as described herein and methods and uses thereof as probes in the mass tagging of biosensors or biologically active materials for use in mass cytometry analysis of tissue samples such as in the detection, labelling and quantification of oxygen-deprived cells by using, for example, tellurophene-tagged 2-nitroimidazole.

  具有公式(I)的化合物，以及将其作为探针用于生物传感器或生物活性材料的质量标记的方法和用途，例如使用镉印记的2-硝基咪唑在组织样本的质量细胞术分析中检测、标记和量化缺氧细胞。
• Organotellurium compounds, compositions and methods of use thereof
  申请人：THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

  公开号：US10222380B2

  公开（公告）日：2019-03-05

  A compound of formula (I) as described herein and methods and uses thereof as probes in the mass tagging of biosensors or biologically active materials for use in mass cytometry analysis of tissue samples such as in the detection, labelling and quantification of oxygen-deprived cells by using, for example, tellurophene-tagged 2-nitroimidazole.

  本文所述的式(I)化合物及其作为生物传感器或生物活性材料质量标记探针的方法和用途，可用于组织样品的质谱分析，例如使用碲吩标记的 2-硝基咪唑对缺氧细胞进行检测、标记和定量。
• Activity-based fluorescent probes that target phosphatases
  作者：Qing Zhu、Xuan Huang、Grace Y.J. Chen、Shao Q. Yao

  DOI：10.1016/s0040-4039(03)00348-4

  日期：2003.3

  We have successfully designed and synthesized two fluorescently-labeled, activity-based probes, Probe I and Probe 2, which were shown to label protein tyrosine phosphatases specifically, as well as other types of phosphatases. The probes were not reactive towards the other non-phosphatase enzymes tested. These probes may find potential applications in large-scale proteomic experiments whereby subclasses of proteins may be selectively identified. (C) 2003 Elsevier Science Ltd. All rights reserved.
• ORGANOTELLURIUM COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF
  申请人：THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

  公开号：US20170269094A1

  公开（公告）日：2017-09-21

  A compound of formula (I) as described herein and methods and uses thereof as probes in the mass tagging of biosensors or biologically active materials for use in mass cytometry analysis of tissue samples such as in the detection, labelling and quantification of oxygen-deprived cells by using, for example, tellurophene-tagged 2-nitroimidazole.
• Organotellurium Compounds, Compositions and Methods of Use Thereof
  申请人：The Governing Council of the University of Toronto

  公开号：US20210102949A1

  公开（公告）日：2021-04-08

  A compound of formula (I): as described herein and methods and uses thereof as for mass tagging a biosensor or biologically active material.