The present invention is directed to bicyclic heteroaryl benzamide compounds of formulas (I) which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.
本发明涉及式(I)所示的二环杂芳基
苯甲
酰胺化合物,该化合物是肌动蛋白相关激酶(Trk)家族蛋白激酶
抑制剂,因此可用于治疗疼痛、炎症、癌症、再狭窄、动脉粥样硬化、
银屑病、血栓形成、与髓鞘形成不良或
脱髓鞘相关的疾病、障碍、损伤或功能障碍,或与神经生长因子(NGF)受体TrkA的异常活性相关的疾病或障碍。