Disodium 5-methyltetrahydrofolate | 77290-64-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 英文名称: Disodium 5-methyltetrahydrofolate
• 英文别名: disodium;(2S)-2-[[4-[(2-amino-5-methyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioate
• CAS: 77290-64-3
• 化学式: C20H23N7Na2O6
• 分子量: 503.4
• InChiKey: KKIWVYLOTHCGRV-RIWFDJIXSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -7.8
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  209
• 氢给体数：
  5
• 氢受体数：
  12

文献信息

• Pharmaceutical compositions and therapeutic applications for the use of a novel vitamin B12 derivative, N-acetyl-L-cysteinylcobalamin
  申请人：Brasch E. Nicola

  公开号：US20080076733A1

  公开（公告）日：2008-03-27

  Therapeutic applications, such as prevention, treatment and supplementation, for the use of novel and other thiolatocobalamins to protect human cells against the effects of oxidative stress. In particular, this invention relates to the use of a novel synthetic thiolatocobalamin, N-acetyl-L-cysteinylcobalamin (NACCbl) to protect animal cells against oxidative stress damage. This invention also relates to the use of thiolatocobalamins, such as NACCbl, in lieu of current, commercially available forms of vitamin B 12 for the treatment and prevention of conditions associated with oxidative stress damage and for dietary supplementation.

  治疗应用，如预防、治疗和补充，用于利用新型和其他硫代胺基钴胺保护人类细胞免受氧化应激的影响。具体而言，本发明涉及使用一种新型合成硫代胺基钴胺，N-乙酰-L-半胱氨酰胺基钴胺（NACCbl）来保护动物细胞免受氧化应激损伤。本发明还涉及使用硫代胺基钴胺，如NACCbl，代替当前市售的维生素B12形式，用于治疗和预防与氧化应激损伤相关的疾病，并用于膳食补充。
• Pharmaceutical compositions and therapeutic applications for the use of a synthetic vitamin B12 derivative, glutathionylcobalamin
  申请人：Brasch E. Nicola

  公开号：US20080113900A1

  公开（公告）日：2008-05-15

  Therapeutic applications, such as prevention, treatment and supplementation, for the use of novel and other thiolatocobalamins to protect human cells against the effects of oxidative stress. In particular, this invention relates to the use of a novel synthetic thiolatocobalamin, glutathionylcobalamin to protect animal cells against oxidative stress damage. This invention also relates to the use of thiolatocobalamins, such as glutathionylcobalamin, in lieu of current, commercially available forms of vitamin B 12 for the treatment and prevention of conditions associated with oxidative stress damage and for dietary supplementation.
• US7812042B2
  申请人：——

  公开号：US7812042B2

  公开（公告）日：2010-10-12