2,6-dimethyldecahydro-1,5-naphthyridine | 1584222-79-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2,6-dimethyldecahydro-1,5-naphthyridine
• 英文别名: (2R,4aR,6S,8aS)-2,6-dimethyl-1,2,3,4,4a,5,6,7,8,8a-decahydro-1,5-naphthyridine
• CAS: 1584222-79-6
• 化学式: C₁₀H₂₀N₂
• 分子量: 168.282
• InChiKey: LQPIKJMBUZADGZ-FIRGSJFUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,6-dimethyl-1,5-naphthyridine 在 Cp(*)Ir(H)4 、 2,9-dihydroxy-1,10-phenanthroline 、 氢气 作用下， 以 对二甲苯 为溶剂， 130.0 ℃ 、7.09 MPa 条件下， 反应 20.0h， 以78%的产率得到(2S,6S,9R,10R)-2,6-dimethyl-1,5-diaza-cis-decalin
  参考文献：
  名称：

  Homogeneous Perdehydrogenation and Perhydrogenation of Fused Bicyclic N-Heterocycles Catalyzed by Iridium Complexes Bearing a Functional Bipyridonate Ligand

  摘要：

  Homogeneous perdehydrogenation of saturated bicyclic 2,6-dimethyldecahydro-1,5-naphthyridine and perhydrogenation of aromatic 2,6-dimethyl-1,5-naphthyridine with release and uptake of five molecules of H-2 are efficiently achieved by iridium complexes bearing a functional bipyridonate ligand. Successive perhydrogenation and perdehydrogenation of 2,6-dimethyl-1,5-naphthryridine using a single iridium complex also proceed with the reversible inter-conversion of the catalytic species, depending on the presence or absence of H-2.

  DOI：

  10.1021/ja5001888

文献信息

• Homogeneous Perdehydrogenation and Perhydrogenation of Fused Bicyclic N-Heterocycles Catalyzed by Iridium Complexes Bearing a Functional Bipyridonate Ligand
  作者：Ken-ichi Fujita、Yui Tanaka、Masato Kobayashi、Ryohei Yamaguchi

  DOI：10.1021/ja5001888

  日期：2014.4.2

  Homogeneous perdehydrogenation of saturated bicyclic 2,6-dimethyldecahydro-1,5-naphthyridine and perhydrogenation of aromatic 2,6-dimethyl-1,5-naphthyridine with release and uptake of five molecules of H-2 are efficiently achieved by iridium complexes bearing a functional bipyridonate ligand. Successive perhydrogenation and perdehydrogenation of 2,6-dimethyl-1,5-naphthryridine using a single iridium complex also proceed with the reversible inter-conversion of the catalytic species, depending on the presence or absence of H-2.