1-(7-bromo-2-methylheptan-2-yl)-2-(tert-butyl)diazene | 1605291-05-1

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 炔丙基型1，3-偶极有机化合物
• 英文名称: 1-(7-bromo-2-methylheptan-2-yl)-2-(tert-butyl)diazene
• CAS: 1605291-05-1
• 化学式: C₁₂H₂₅BrN₂
• 分子量: 277.248
• InChiKey: BTAGLHJGWPPMKF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.97
• 重原子数：
  15.0
• 可旋转键数：
  6.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  24.72
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  1,5-二溴戊烷 、 acetone tert-butylhydrazone 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 6.55h， 以26%的产率得到1-(7-bromo-2-methylheptan-2-yl)-2-(tert-butyl)diazene
  参考文献：
  名称：

  DNA Damage by Histone Radicals in Nucleosome Core Particles

  摘要：

  Although DNA binding proteins shield the genetic material from diffusible reactive oxygen species by reacting with them, the resulting protein (peroxyl) radicals can oxidize the bound DNA. To explore this possible DNA damage by protein radicals, histone H4 proteins containing an azoalkane radical precursor at defined sites were prepared. Photolysis of a nucleosome core particle containing the modified protein produces DNA damage that is consistent with selective C4'-oxidation. The nucleotide(s) damaged is highly dependent on proximity to the protein radical. These experiments provide insight into the effects of oxidative stress on protein-bound DNA, revealing an additional layer of complexity concerning nucleic acid damage.

  DOI：

  10.1021/ja501285s