δ-Amino-α-methyl-laevulinsaeure | 13115-32-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: δ-Amino-α-methyl-laevulinsaeure
• 英文别名: Methyl 5-aminolevulinic acid；5-amino-2-methyl-4-oxopentanoic acid
• CAS: 13115-32-7
• 化学式: C₆H₁₁NO₃
• mdl: MFCD19205332
• 分子量: 145.158
• InChiKey: HJBHOJZDRYXROF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.2
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  80.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  δ-Phthalimido-α-methyl-laevulinsaeure-methylester 在 盐酸 作用下， 生成 δ-Amino-α-methyl-laevulinsaeure
  参考文献：
  名称：

  Synthesis of Analogs of δ-Aminolevulinic Acid^*,1

  摘要：

  DOI：

  10.1021/jo01017a514

文献信息

• BUTYRIC ACID SALT OF N,N-DIMETHYL IMIDOCARBON IMIDIC DIAMIDE, METHOD OF PREPARING SAME, AND PHARMACEUTICAL COMPOSITIONS AND COMBINATIONS CONTAINING SAME
  申请人：Kim Sung Wuk

  公开号：US20120135952A1

  公开（公告）日：2012-05-31

  The present invention provides metformin butyric acid salt, a method of preparing the same, and pharmaceutical compositions and combinations containing the same. The metformin butyric acid salt according to the present invention has an excellent pharmacological effect as compared with metformin hydrochloride and is capable of achieving a therapeutic purpose by administering an amount less than metformin hydrochloride. Furthermore, the metformin butyric acid salt has excellent physicochemical properties, such as solubility, stability, hygroscopicity and adsorption preventing property, in processibility of formulations and thereby is capable of being usefully utilized as a pharmaceutically acceptable salt of the metformin.

  本发明提供了丁酸盐酸二甲双胍、其制备方法，以及含有该盐酸二甲双胍的药物组合物和药物组合物。根据本发明，盐酸二甲双胍丁酸盐具有比盐酸二甲双胍更优异的药理效果，并且可以通过比盐酸二甲双胍更少的用量实现治疗目的。此外，盐酸二甲双胍丁酸盐在制剂的加工过程中具有优异的物理化学性质，如溶解度、稳定性、吸湿性和吸附防止性能，因此可以作为盐酸二甲双胍的药用可接受盐酸。
• [EN] ACID ADDITION SALTS OF 5-AMINOLEVULINIC ACID OR ITS DERIVATIVES<br/>[FR] SELS D'ADDITION ACIDE D'ACIDE 5-AMINOLEVULINIQUE OU DE SES DERIVES
  申请人：PHOTOCURE ASA

  公开号：WO2005092838A1

  公开（公告）日：2005-10-06

  The present invention provides an acid addition salt of 5-aminolevulinic acid (5-ALA) or of a 5-ALA derivative (e.g. a 5-ALA ester) with an acid which has a pKa of about 5 or less, preferably about 3 or less, with the proviso that the acid is other than hydrochloric acid. Particularly preferred salts are those derived from acids selected from the group comprising sulphonic acid and its derivatives, hydrobromic acid, sulfuric acid, nitric acid and phosphoric acid. The salts in accordance with the invention are particularly suitable for use as photosensitizing agents in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body.

  本发明提供了一种5-氨基戊酸（5-ALA）或5-ALA衍生物（例如5-ALA酯）的酸加成盐，所述酸具有大约5或更低的pKa值，优选大约3或更低的pKa值，但该酸不包括盐酸。特别优选的盐是来源于选自磺酸及其衍生物，氢溴酸，硫酸，硝酸和磷酸组成的酸的盐。根据本发明的盐特别适用于用作诊断和光化疗治疗身体内外表面的疾病或异常的光敏剂。
• Nalpha, Nalpha, Nalpha-TRIALKYL HISTIDINE DERIVATIVES USEFUL FOR THE PREPARATION OF ERGOTHIONEINE COMPOUNDS
  申请人：Trampota Jan

  公开号：US20170050933A1

  公开（公告）日：2017-02-23

  Provided herein are N α ,N α ,N α -trialkyl histidine derivative compounds and methods of their preparation. Also provided are methods of their use for preparing useful compounds such as ergothioneine.

  本文提供了Nα，Nα，Nα-三烷基组氨酸衍生物化合物及其制备方法。还提供了它们的使用方法，用于制备有用的化合物，如麦角硫氨酸。
• Acid Addition Salts Of-5-Aminolevulinic Acid Or Its Derivatives
  申请人：Braenden Jon Erik

  公开号：US20080064752A1

  公开（公告）日：2008-03-13

  The present invention provides an acid addition salt of 5-aminolevulinic acid (5-ALA) or of a 5-ALA derivative (e.g. a 5-ALA ester) with an acid which has a pKa of about 5 or less, preferably about 3 or less, with the proviso that the acid is other than hydrochloric acid. Particularly preferred salts are those derived from acids selected from the group comprising sulphonic acid and its derivatives, hydrobromic acid, sulfuric acid, nitric acid and phosphoric acid. The salts in accordance with the invention are particularly suitable for use as photosensitizing agents in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body.

  本发明提供了5-氨基戊酸（5-ALA）或5-ALA衍生物（例如5-ALA酯）与具有pKa约为5或更低的酸（优选约为3或更低），但该酸不是盐酸的酸加成盐。特别优选的盐是由选自磺酸及其衍生物、氢溴酸、硫酸、硝酸和磷酸的酸所衍生的盐。本发明的盐特别适用于作为诊断和光化学治疗身体内部或外部表面的疾病或异常的光敏剂。
• ACID ADDITION SALTS OF 5-AMINOLEVULINIC ACID OR ITS DERIVATIVES
  申请人：BRAENDEN Jon Erik

  公开号：US20110125012A1

  公开（公告）日：2011-05-26

  The present invention provides an acid addition salt of 5-aminolevulinic acid (5-ALA) or of a 5-ALA derivative (e.g. a 5-ALA ester) with an acid which has a pKa of about 5 or less, preferably about 3 or less, with the proviso that the acid is other than hydrochloric acid. Particularly preferred salts are those derived from acids selected from the group comprising sulphonic acid and its derivatives, hydrobromic acid, sulfuric acid, nitric acid and phosphoric acid. The salts in accordance with the invention are particularly suitable for use as photosensitizing agents in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body.

  本发明提供了一种5-氨基戊酸（5-ALA）或5-ALA衍生物（例如5-ALA酯）与pKa约为5或更低（优选约为3或更低）的酸的酸加成盐，但该酸不是盐酸。特别优选的盐是从磺酸及其衍生物、氢溴酸、硫酸、硝酸和磷酸组成的酸中选择的。根据本发明的盐特别适用于作为诊断和光化学治疗身体内外表面的疾病或异常的光敏剂。