5-glycylamino-valeric acid | 83891-64-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 5-glycylamino-valeric acid
• 英文别名: 5-Glycylamino-valeriansaeure；5-[(2-Aminoacetyl)amino]pentanoic acid
• CAS: 83891-64-9
• 化学式: C₇H₁₄N₂O₃
• 分子量: 174.2
• InChiKey: HJDNAANQDQNKKR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.4
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  92.4
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 甲醇 、 钯 作用下， 生成 5-glycylamino-valeric acid
  参考文献：
  名称：

  Davis; Smith, Journal of Biological Chemistry, 1955, vol. 214, p. 209,212

  摘要：

  DOI：

文献信息

• NANOCARRIERS HAVING SURFACE CONJUGATED PEPTIDES AND USES THEREOF FOR SUSTAINED LOCAL RELEASE OF DRUGS
  申请人：Northwestern University

  公开号：US20180092988A1

  公开（公告）日：2018-04-05

  Disclosed are biodegradable nanocarriers that have a net positive surface charge and zeta potential between about +2 to about +20 mV. The positive surface charge of the nanocarriers is provided by peptides that are covalently attached to the surface of the nanocarriers. The nanocarriers may comprise a drug and may be administered for localized and sustained delivery of the drug.

  揭示了具有净正表面电荷和ζ电位在约+2到约+20 mV之间的可生物降解纳米载体。纳米载体的正表面电荷由共价附着在纳米载体表面的肽提供。这些纳米载体可能包含药物，并可用于药物的局部和持续释放。
• Nanocarriers having surface conjugated peptides and uses thereof for sustained local release of drugs
  申请人：Northwestern University

  公开号：US10583199B2

  公开（公告）日：2020-03-10

  Disclosed are biodegradable nanocarriers that have a net positive surface charge and zeta potential between about +2 to about +20 mV. The positive surface charge of the nanocarriers is provided by peptides that are covalently attached to the surface of the nanocarriers. The nanocarriers may comprise a drug and may be administered for localized and sustained delivery of the drug.

  所公开的可生物降解纳米载体具有净正表面电荷，ZETA电位介于约+2至约+20 mV之间。纳米载体的正表面电荷由共价连接到纳米载体表面的肽提供。纳米载体可包含药物，并可用于局部和持续给药。
• [EN] MODIFIED PIGMENT EPITHELIUM-DERIVED FACTOR (PEDF) PEPTIDES AND USES THEREOF FOR TREATING NEOVASCULAR DISEASES, INFLAMMATORY DISEASES, CANCER, AND FOR CYTOPROTECTION<br/>[FR] PEPTIDES DU FACTEUR DÉRIVÉ DE L'ÉPITHÉLIUM PIGMENTAIRE MODIFIÉ (PEDF) ET LEURS UTILISATIONS POUR LE TRAITEMENT DE MALADIES NÉOVASCULAIRES, DE MALADIES INFLAMMATOIRES, DU CANCER ET POUR LA CYTOPROTECTION
  申请人：UNIV NORTHWESTERN

  公开号：WO2017189715A1

  公开（公告）日：2017-11-02

  Disclosed are modified pigment epithelium-derived factor (PEDF) peptides, particulate carrier prodrugs thereof, and pharmaceutical compositions comprising the peptides or particulate carrier prodrugs. The peptides, particulate carrier prodrugs, and pharmaceutical compositions may be used to treat diseases and disorders that are amenable to treatment with anti-angiogenic agents, anti-tumorigenic agents, anti- fibrotic agents, chemotherapy-protecting agents, and immune stimulating agents.
• [EN] NANOCARRIERS HAVING SURFACE CONJUGATED PEPTIDES AND USES THEREOF FOR SUSTAINED LOCAL RELEASE OF DRUGS<br/>[FR] NANO-PORTEURS AYANT DES PEPTIDES CONJUGUÉS EN SURFACE ET LEURS UTILISATIONS POUR UNE LIBÉRATION LOCALE PROLONGÉE DE MÉDICAMENTS
  申请人：UNIV NORTHWESTERN

  公开号：WO2018089465A1

  公开（公告）日：2018-05-17

  Disclosed are biodegradable nanocarriers that have a net positive surface charge and zeta potential between about +2 to about +20 mV. The positive surface charge of the nanocarriers is provided by peptides that are covalently attached to the surface of the nanocarriers. The nanocarriers may comprise a drug and may be administered for localized and sustained delivery of the drug.