1-Methylsulfonyl-4-phenylmethoxybenzene | 81499-31-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Methylsulfonyl-4-phenylmethoxybenzene
• CAS: 81499-31-2
• 化学式: C₁₄H₁₄O₃S
• 分子量: 262.329
• InChiKey: GHEPDMDXPLPAJJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-Methylsulfonyl-4-phenylmethoxybenzene 在 sodium azide 作用下， 生成 1-azido-4-(benzyloxy)benzene
  参考文献：
  名称：

  Non-urea functionality as the primary pharmacophore in soluble epoxide hydrolase inhibitors

  摘要：

  Inhibition of soluble epoxide hydrolase has been proposed as a promising new pharmaceutical target for diseases involving hypertension and vascular inflammation. The most potent sEH inhibitors reported to date contain a urea or amide moiety as the central or 'primary' pharmacophore. We evaluated replacing the urea pharmacophore with other functional groups such as thiourea, sulfonamide, sulfonylurea, aminomethylene amide, hydroxyamide, and ketoamide to identify novel and potent inhibitors. The hydroxyamide moiety was identified as a novel pharmacophore affording potency comparable to urea. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.01.013

文献信息

• Highly stereoselective monofluoroolefination: Facile access to (E)-α-fluorinated arylvinyl sulfones from trifluoromethyl α-fluorinated arylsulfonyl gem-diols
  作者：Xiang Fang、Jun Zhou、Wang Wang、Xueyan Yang、Fanhong Wu

  DOI：10.1016/j.tetlet.2020.151964

  日期：2020.6

  sulfones employing trifluoromethyl α-fluorinated arylsulfonyl gem-diols and aryl aldehydes under mild reaction conditions has been developed, which affords α-fluorinated arylvinyl sulfones in high yields with E-isomer only. The desired products can be further transformed into more useful fluoroolefins through debenzenesulfonyl process.

  已经开发了在温和的反应条件下利用三氟甲基α-氟化芳基磺酰基宝石-二醇和芳基醛的出色的立体选择性直接合成三取代（E）-α-氟化芳基乙烯基砜的方法，该方法可通过E-异构体以高收率获得α-氟化芳基乙烯基砜。只要。所需产物可以通过脱苯磺酰基方法进一步转化为更有用的氟代烯烃。
• Construction of N-Boc monofluoromethyl aryl sulfones via Mannich reaction of α-amido sulfones with trifluoromethyl α-fluorinated arylsulfonyl gem-diols
  作者：Wang Wang、Xiang Fang、Xueyan Yang、Fanhong Wu

  DOI：10.1016/j.jfluchem.2020.109537

  日期：2020.7

  A mild and efficient nucleophilic monofluoromethylation of α-amido sulfones with trifluoromethyl α-fluorinated arylsulfonyl gem-diols as new building blocks has been developed, which affords N-Boc monofluoromethyl aryl sulfones in good yields with appropriate 5:1 diastereomeric ratio.

  已经开发出温和有效的α-酰胺基砜亲核单氟甲基化与三氟甲基α-氟化的芳基磺酰基宝石二醇作为新的结构单元，它可以以适当的5：1非对映体比率以良好的收率提供N-Boc单氟甲基芳基砜。
• Pyrrole compounds
  申请人：Kajino Masahiro

  公开号：US20080262042A1

  公开（公告）日：2008-10-23

  The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity, which is represented by the formula (I) wherein R 1 is an optionally substituted cyclic group, R 2 is a substituent, R 3 is an optionally substituted alkyl group, an acyl group, an optionally substituted hydroxy group, an optionally substituted amino group, a halogen atom, a cyano group or a nitro group, R 4 and R 5 are each a hydrogen atom, an optionally substituted alkyl group, an acyl group, an optionally substituted hydroxy group, an optionally substituted amino group, a halogen atom, a cyano group or a nitro group, R 6 and R 6′ are each a hydrogen atom or an alkyl group, and n is an integer of 0-3, or a salt thereof.

  本发明提供了一种具有优异的抑制酸分泌作用和显示抗溃疡活性的化合物，其由式（I）表示，其中R1是一个可选取代的环烷基，R2是一个取代基，R3是一个可选取代的烷基、酰基、可选取代的羟基、可选取代的氨基、卤素原子、氰基或硝基，R4和R5分别是氢原子、可选取代的烷基、酰基、可选取代的羟基、可选取代的氨基、卤素原子、氰基或硝基，R6和R6'分别是氢原子或烷基，n为0-3的整数，或其盐。
• OXIME COMPOUNDS AND THE USE THEREOF
  申请人：Matsumura Akira

  公开号：US20090298878A1

  公开（公告）日：2009-12-03

  The invention relates to oxime compounds of Formula (I) and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein X is hydrogen, optionally substituted aryl, optionally substituted heteroaryl or the like; Y is CO, SO 2 , CR 3 R 4 or the like; Z is optionally substituted lower alkyl, optionally substituted aryl or the like; W is optionally substituted lower alkylene or optionally substituted lower alkenylene, R 3 and R 4 are each independently hydrogen, lower alkyl or the like; p is 0, 1, or 2 and q is 0, 1 or 2. The invention is also directed to the use compounds of Formula I to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.

  本发明涉及式(I)的肟化合物及其药学上可接受的盐、前药或溶剂，其中X为氢、可选取代芳基、可选取代杂环基或类似物；Y为CO、SO2、CR3R4或类似物；Z为可选取代的低烷基、可选取代的芳基或类似物；W为可选取代的低烷基或可选取代的低烯基，R3和R4各自独立地为氢、低烷基或类似物；p为0、1或2，q为0、1或2。本发明还涉及使用式(I)的化合物来治疗、预防或改善对钙通道封锁有反应的疾病，特别是N型钙通道。本发明的化合物特别适用于治疗疼痛。
• Plant growth regulators and their use
  申请人：J.T. Baker Chemical Co.

  公开号：EP0044536A1

  公开（公告）日：1982-01-27

  Benzyl phenyl ethers are disclosed as inhibitors of cytokinin plant growth regulatory activity and as possessing seed germination regulatory properties and senescence delaying activity when applied to plants. Benzyl phenyl ethers may also be useful as plant dwarfing agents, agents to retard seedling development or as herbicides.

  苄基苯基醚是细胞分裂素植物生长调节活性的抑制剂，应用于植物时具有种子发芽调节特性和延缓衰老活性。苄基苯基醚还可用作植物矮化剂、幼苗发育迟缓剂或除草剂。