(S)-1-hexadecyl-2-(4-carboxy)butyl-sn-glycerol | 935656-58-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: (S)-1-hexadecyl-2-(4-carboxy)butyl-sn-glycerol
• 英文别名: 5-[(2S)-1-hexadecoxy-3-hydroxypropan-2-yl]oxypentanoic acid
• CAS: 935656-58-9
• 化学式: C₂₄H₄₈O₅
• 分子量: 416.642
• InChiKey: SJADMKIMEGBIOS-QHCPKHFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  29
• 可旋转键数：
  24
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  甲醇 、 (S)-1-hexadecyl-2-(4-carboxy)butyl-sn-glycerol 在 盐酸 作用下， 以 水 为溶剂， 以96.2%的产率得到(S)-1-hexadecyl-2-(4-methylcarboxy)butyl-sn-glycerol
  参考文献：
  名称：

  [EN] OXIDIZED LIPID COMPOUNDS AND USES THEREOF
  [FR] COMPOSÉS LIPIDIQUES OXYDÉS ET LEURS UTILISATIONS

  摘要：

  公开号：

  WO2010052718A9
• 作为产物：
  描述：

  3-hexadecyloxy-2-(5'-hexenyloxy)-sn-1-trityloxypropane 在 potassium permanganate 、 sodium periodate 、 碳酸氢钠 、 盐酸 作用下， 以 叔丁醇 、 水 为溶剂， 反应 3.0h， 以64.3%的产率得到(S)-1-hexadecyl-2-(4-carboxy)butyl-sn-glycerol
  参考文献：
  名称：

  [EN] OXIDIZED LIPID COMPOUNDS AND USES THEREOF
  [FR] COMPOSÉS LIPIDIQUES OXYDÉS ET LEURS UTILISATIONS

  摘要：

  公开号：

  WO2010052718A9

文献信息

• Process for the preparation of oxidized phospholipids
  申请人：Halperin Gideon

  公开号：US20070112211A1

  公开（公告）日：2007-05-17

  Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorous-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby.

  本发明揭示了一种新的合成路线，非常适用于工业制备具有治疗益处的氧化磷脂类化合物。特别是，本发明揭示了一种高效制备具有甘油骨架和一个或多个氧化基团连接到甘油骨架上的化合物的新方法，该方法不需要使用柱层析。此外，本发明还揭示了将含磷基团（如磷酸盐基团）引入具有甘油骨架和由此形成的中间体的化合物的新方法。
• OXIDIZED LIPID COMPOUNDS AND USES THEREOF
  申请人：Kovalevski-Ishai Eti

  公开号：US20110207703A1

  公开（公告）日：2011-08-25

  Novel oxidized lipids are provided herein, as well as methods for producing same, and uses thereof in treating or preventing an inflammation associated with endogenous oxidized lipids and related conditions.

  本文提供了新型氧化脂类化合物，以及制备方法，以及将其用于治疗或预防与内源性氧化脂类化合物和相关疾病相关的炎症的用途。
• PROCESS FOR THE PREPARATION OF OXIDIZED PHOSPHOLIPIDS
  申请人：Halperin Gideon

  公开号：US20120130108A1

  公开（公告）日：2012-05-24

  Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorous-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby.

  本发明揭示了一种新型合成路线，适用于工业制备治疗有益的氧化磷脂。特别是，揭示了一种高效制备具有甘油骨架和一个或多个氧化物附着在甘油骨架上的化合物的新方法，这些方法不需要柱层析。此外，还揭示了一种引入含磷基团（如磷酸盐基团）到具有甘油骨架的化合物和由此形成的中间体的新方法。
• Process for the Preparation of Oxidized Phospholipids
  申请人：Vascular Biogenics Ltd.

  公开号：US20130158283A1

  公开（公告）日：2013-06-20

  Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorous-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby.

  揭示了一种新的合成路线，适用于工业制备具有治疗效果的氧化磷脂类化合物。特别是，揭示了一种高效制备具有甘油骨架和一个或多个氧化基团附着在甘油骨架上的化合物的新方法，这些方法不需要使用柱层析法。此外，还揭示了一种引入含磷基团（如磷酸盐基团）到具有甘油骨架的化合物和由此形成的中间体的新方法。
• High-Purity Phospholipids
  申请人：HALPERIN Gideon

  公开号：US20130079540A1

  公开（公告）日：2013-03-28

  Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorus-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby. Further disclosed is substantially pure 1-hexadecyl-2-(4′-carboxy)butyl-sn-glycero-3-phosphocholine (CI-201).

  本发明揭示了一种新的合成路线，非常适用于工业制备治疗上有益的氧化磷脂。特别地，本发明揭示了一种高效制备具有甘油骨架和一个或多个氧化基团附着在甘油骨架上的化合物的新方法，这些方法不需要柱层析。进一步揭示了一种引入含磷基团（如磷酸盐基团）到具有甘油骨架和由此形成的中间体的新方法。进一步揭示了几乎纯的1-十六烷基-2-(4'-羧基)丁基-sn-甘油-3-磷酸胆碱（CI-201）。